Facial pain and multiple cranial palsies in a patient with skin cancer

Viken, Janina; Bendtsen, Lars; Hansen, Klaus; Katholm, Morten; Laursen, Henning; Hastrup, Nina; Gideon, Peter; Ashina, Messoud

doi:10.1007/s10194-011-0324-6

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…There is a reported incidence of perineural spread of 1% for basal cell carcinomas and 2–14% for SCC . Patients usually present with paresthesia, followed by neuropathic pain in the area previously affected by the skin cancer . Although perineural invasion may be of importance, we did not observe this histologic feature in any of the 266 SCC diagnosed.…”

Section: Discussioncontrasting

confidence: 71%

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Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

Bavinck

Harwood

Genders

et al. 2014

American Journal of Transplantation

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Organ transplant recipients (OTR) are at high risk for cutaneous squamous cell carcinomas (SCC). We aimed to define clinically meaningful patient‐reported warning signals predicting the presence of invasive SCC. Patient‐reported signs and symptoms of 812 consecutively biopsied skin lesions from 410 OTR were determined by questionnaire and physical examination and related to the subsequent biopsy‐proven diagnoses. Receiver‐operating characteristic (ROC) curve analyses were used as a measure of distinction between the predictive values of patient‐reported warning signals and the occurrence of SCC. Pain was an independent predictive patient‐reported warning signal for a biopsy‐proven invasive SCC. The odds ratio from the fully adjusted model predicting SCC was 4.4 (95% confidence interval: 2.4–8.2). Higher scores on the visual analog scale (VAS) for pain were associated with a greater likelihood for the presence of SCC compared to none or mild pain. The for scores on the VAS from 1 to 3, 4 to 6 and 7 to 10 were 4.9 (2.2–10.5), 2.3 (0.96–5.5) and 16.5 (3.6–75.8), respectively. Pain is the most powerful patient‐reported warning signal for invasive cutaneous SCC in OTR. Empowerment of patients by education could accelerate diagnosis and treatment of cutaneous SCC.

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Section: Discussioncontrasting

confidence: 71%

“…The reason why an SCC is often painful is poorly understood. There is a reported incidence of perineural spread of 1% for basal cell carcinomas and 2–14% for SCC . Patients usually present with paresthesia, followed by neuropathic pain in the area previously affected by the skin cancer .…”

Section: Discussionmentioning

confidence: 99%

Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

Bavinck

Harwood

Genders

et al. 2014

American Journal of Transplantation

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Neuromuscular complications in cancer

Grisold

Löscher

2016

Journal of the Neurological Sciences

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Cancer around the brain

Grisold

2014

Neuro-Oncology Practice

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Background Neuro-oncologists are familiar with primary brain tumors, intracerebral metastases meningeal carcinomatosis and extracerebral intracranial tumors as meningeoma. For these conditions, and also some other rare tumor entities several treatment options exist. Cancer can also involve structures around the brain as the dura, the base of the skull, the cavities of the skull and tissue around the bony skull, the skin, the tissue of the neck. and either compress, invade or spread in the central or peripheral nervous system. Methods A systematic literature research was conducted determining symptoms and signs, tumor sites of nerve invasion, tumor types, diagnostic techniques, mechanisms of nerve invasion, and important differential diagnosis. Additional cases from own experience were added for illustration. Results The mechanisms of tumor invasion of cranial nerves is heterogenous and not only involves several types of invasion, but also spread along the cranial nerves in antero- and retrograde fashion and even spread into different nerve territories via anastomosis. In addition the concept of angiosomas may have an influence on the spread of metastases. Conclusion In addition to the well described tumor spread in meningeal carcinomatosis and base of the skull metastases, dural spread, lesions of the bony skull, the cavities of the skull and skin of the face and tissue of the neck region need to be considered, and have an impact on therapeutic decisions.

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Facial pain and multiple cranial palsies in a patient with skin cancer

Cited by 6 publications

References 10 publications

Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

Neuromuscular complications in cancer

Cancer around the brain

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