Facile alternative route to cis -[PtCl 2 (PTA) 2 ] and [PtCl(PTA) 3 ]Cl (PTA = 1,3,5-triaza-7-phosphaadamantane)

Palladium(II) and platinum(II) chloro complexes of novel water‐soluble cage‐like phosphane CAP (1,4,7‐triaza‐9‐phosphatricyclo[5.3.2.14,9]tridecane) have been synthesized and characterized in comparison with their counterparts bearing well known PTA (1,3,5‐triaza‐7‐phosphaadamantane) ligand. A peculiar structural feature of studied cis‐[MCl2L2] complexes is the occurrence of interligand C−Hσ+⋅⋅⋅σ+H−C interactions (hydrogen‐hydrogen bonds) between the phosphane cages: the first case encountered so far among metal‐phosphane complexes. Due to substantial stabilizing contribution to the net molecular energy of the complexes (∼ 20 kcal mol−1), hydrogen‐hydrogen bonding is sufficient to maintain sterically overcrowded cis conformations of the complexes. The interplay between protonation stage of the ligands and their conformations can be a reason of significant differences in in‐vitro cytotoxicity between CAP complexes and their PTA‐bearing counterparts.

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Palladium(II) and Platinum(II) Complexes of Novel Water-Soluble Phosphane CAP: Structure, Interligand Hydrogen-Hydrogen Bonding and in Vitro Cytotoxicity

Britvin

Rumyantsev

Silyutina

et al. 2017

ChemistrySelect

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Coordination chemistry of 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and applications

Guerriero

Peruzzini

Gonsalvi

2018

Coordination Chemistry Reviews

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Synthesis and characterization of Pt complexes containing dichloroacetate (DCA), designed for dual anticancer action

Ferretti

Bergamini

Marvelli

et al. 2018

Inorganica Chimica Acta

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Facile alternative route to cis -[PtCl 2 (PTA) 2 ] and [PtCl(PTA) 3 ]Cl (PTA = 1,3,5-triaza-7-phosphaadamantane)

Cited by 5 publications

References 27 publications

Palladium(II) and Platinum(II) Complexes of Novel Water-Soluble Phosphane CAP: Structure, Interligand Hydrogen-Hydrogen Bonding and in Vitro Cytotoxicity

Palladium(II) and Platinum(II) Complexes of Novel Water-Soluble Phosphane CAP: Structure, Interligand Hydrogen-Hydrogen Bonding and in Vitro Cytotoxicity

Coordination chemistry of 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and applications

Synthesis and characterization of Pt complexes containing dichloroacetate (DCA), designed for dual anticancer action

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