Facile and an efficient one-pot synthesis of 2-arylbenzoxazoles promoted by transition metal oxide nano catalyst

Abstract

The advantages and an efficient path way of process for 2-arylbenzoxazole can be obtained by transition metal oxide Nano catalyst. The transition metal nano TiO2 catalysed and a tandem reaction between substituted 2-aminophenols and substituted aromatic aldehydes to produces scaffold series of 15 smoothly forming benzo heterocycles with good to excellent yields (80-94%). The synthesized benzoxazole compounds were confirmed by FT-IR, 1H, 13CNMR, and mass spectroscopy. This article describes a one-stage coupling technique that provides a unique way to access variously functionalized benzoxazole scaffolds. This methodology consists of a one-pot combination of condensation followed by oxidative addition reactions. It was shown that nano TiO2 in ethanol encouraged the formation of 2-aryl benzoxazole scaffolds and this catalyst quickly boosted the cascade reaction that produced a variety of collections of named derivatives. These protocols are atom-economic, efficient, reusable and modular means of accessing restricted named derivatives that have a substantial substrate tolerance and over ten points of diversity.