Facile and green route polymerization of N-vinyl pyrrolidone under ultrasound-aided dual-site phase transfer catalytic conditions

Marimuthu, Elumalai; Balamurugan, Rathinam; Murugesan, Vajjiravel

doi:10.1007/s00396-022-04979-x

Colloid Polym Sci

2022

DOI: 10.1007/s00396-022-04979-x

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Facile and green route polymerization of N-vinyl pyrrolidone under ultrasound-aided dual-site phase transfer catalytic conditions

Elumalai Marimuthu

Rathinam Balamurugan

Vajjiravel Murugesan

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2024

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Cited by 2 publications

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Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Petrová,

Chvíla,

Štěpánek

et al. 2024

Drug Deliv. and Transl. Res.

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The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug solubility in printing resin, especially if it is predominantly composed of water. The possible solution how to ensure ideal belonging of drug and water-based printing resin is its pre-formulation in nanosuspension such as nanocrystals. This study investigates the feasibility of this approach on a resin containing nanocrystals of imiquimod (IMQ), an active used in (pre)cancerous skin conditions, well known for its problematic solubility and bioavailability. The resin blend of polyethylene glycol diacrylate and N-vinylpyrrolidone, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photoinitiator, was used, mixed with IMQ nanocrystals in water. The final microneedle-patches had 36 cylindrical microneedles arranged in a square grid, measuring approximately 600 μm in height and 500 μm in diameter. They contained 5wt% IMQ, which is equivalent to a commercially available cream. The homogeneity of IMQ distribution in the matrix was higher for nanocrystals compared to usual crystalline form. The release of IMQ from the patches was determined ex vivo in natural skin and revealed a 48% increase in efficacy for nanocrystal formulations compared to the crystalline form of IMQ. Graphical Abstract

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Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Petrová,

Chvíla,

Štěpánek

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

Ultrasonic mediated dual-site phase transfer catalyzed polymerization of N-butenyl isatin in two phase system- a kinetic study

Murugesan,

Marimuthu,

Rathinam

et al. 2024

Journal of Macromolecular Science, Part A

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Facile and green route polymerization of N-vinyl pyrrolidone under ultrasound-aided dual-site phase transfer catalytic conditions

Cited by 2 publications

References 31 publications

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Ultrasonic mediated dual-site phase transfer catalyzed polymerization of N-butenyl isatin in two phase system- a kinetic study

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