Facile fabrication of highly interconnected poly(lactic acid)‐based scaffolds with good hydrophilicity using supercritical carbon dioxide

Chen, Jinwei; Yang, Libin; Chen, Dahua; Wang, Meigui; Lixuan, Wu

doi:10.1002/app.54047

Cited by 5 publications

(1 citation statement)

References 39 publications

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“…The foams produced by injection moulding using azodicarbonamide as the CBA showed a closed-cell structure, narrow cell size distribution, higher cell density (1.8 × 10 5 cells/cm 3 ), and foam density of 0.85 g/cm 3 . Chen et al [447] used poly(ethylene glycol) (PEG) to improve the compatibility between PLA and PBS in order to fabricate PLA-based scaffolds with high porosity through supercritical CO 2 foaming. The PLA/PBS/PEG blend (composition of 90/10/10) foamed under 100 • C showed a volume expansion ratio of 13.98 and open cell rate of 95.9%.…”

Section: Biodegradable Polymer Blendsmentioning

confidence: 99%

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Gonçalves,

Reis,

Fernandes

2024

Polymers

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The last few decades have witnessed significant advances in the development of polymeric-based foam materials. These materials find several practical applications in our daily lives due to their characteristic properties such as low density, thermal insulation, and porosity, which are important in packaging, in building construction, and in biomedical applications, respectively. The first foams with practical applications used polymeric materials of petrochemical origin. However, due to growing environmental concerns, considerable efforts have been made to replace some of these materials with biodegradable polymers. Foam processing has evolved greatly in recent years due to improvements in existing techniques, such as the use of supercritical fluids in extrusion foaming and foam injection moulding, as well as the advent or adaptation of existing techniques to produce foams, as in the case of the combination between additive manufacturing and foam technology. The use of supercritical CO2 is especially advantageous in the production of porous structures for biomedical applications, as CO2 is chemically inert and non-toxic; in addition, it allows for an easy tailoring of the pore structure through processing conditions. Biodegradable polymeric materials, despite their enormous advantages over petroleum-based materials, present some difficulties regarding their potential use in foaming, such as poor melt strength, slow crystallization rate, poor processability, low service temperature, low toughness, and high brittleness, which limits their field of application. Several strategies were developed to improve the melt strength, including the change in monomer composition and the use of chemical modifiers and chain extenders to extend the chain length or create a branched molecular structure, to increase the molecular weight and the viscosity of the polymer. The use of additives or fillers is also commonly used, as fillers can improve crystallization kinetics by acting as crystal-nucleating agents. Alternatively, biodegradable polymers can be blended with other biodegradable polymers to combine certain properties and to counteract certain limitations. This work therefore aims to provide the latest advances regarding the foaming of biodegradable polymers. It covers the main foaming techniques and their advances and reviews the uses of biodegradable polymers in foaming, focusing on the chemical changes of polymers that improve their foaming ability. Finally, the challenges as well as the main opportunities presented reinforce the market potential of the biodegradable polymer foam materials.

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Section: Biodegradable Polymer Blendsmentioning

confidence: 99%

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Gonçalves,

Reis,

Fernandes

2024

Polymers

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Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO₂‐philic materials as nucleating agents

Jiao,

Zhang,

Wang

et al. 2024

J of Applied Polymer Sci

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The iron oxide nanoparticles (IONs), coated with different materials, are synthesized and utilized as nucleating agents to prepare magnetic multi‐modal porous scaffolds of poly (lactic‐co‐glycolic acid)/IONs using the supercritical carbon dioxide (ScCO2) foaming process. The effects of the modification materials, including citric acid, polycaprolactone, and polyvinyl acetate, on the foaming process and properties of the magnetic scaffolds are systematically investigated. The results indicate that the solubility and diffusion ability of CO2 in the foaming materials played a vital role in the foaming process. The use of CO2‐philic materials and high pressure proves beneficial in generating micropores. The scaffolds with multi‐modal porous structures can be obtained at relatively low pressure for the ScCO2 foaming systems evaluated in this study. Furthermore, the prepared scaffolds exhibit high porosity and a good compressive modulus (higher than 0.4 MPa), satisfying the requirements of tissue engineering for soft tissue scaffolds.

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Fabrication magnetic composite scaffolds with multi-modal cell structure for enhanced properties using supercritical CO2 two-step depressurization foaming process

Jiao,

Deng,

Zhang

et al. 2023

Polym. Bull.

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Facile fabrication of highly interconnected poly(lactic acid)‐based scaffolds with good hydrophilicity using supercritical carbon dioxide

Cited by 5 publications

References 39 publications

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO₂‐philic materials as nucleating agents

Fabrication magnetic composite scaffolds with multi-modal cell structure for enhanced properties using supercritical CO2 two-step depressurization foaming process

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Facile fabrication of highly interconnected poly(lactic acid)‐based scaffolds with good hydrophilicity using supercritical carbon dioxide

Cited by 5 publications

References 39 publications

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO2‐philic materials as nucleating agents

Fabrication magnetic composite scaffolds with multi-modal cell structure for enhanced properties using supercritical CO2 two-step depressurization foaming process

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Product

Resources

About

Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO₂‐philic materials as nucleating agents