Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications

Cai, Hong; An, Xiao; Cui, Jun; Li, Jingchao; Wen, Shihui; Li, Kangan; Shen, Mingwu; Zheng, Linfeng; Zhang, Guixiang; Shi, Xiangyang

doi:10.1021/am302883m

Cited by 284 publications

(255 citation statements)

References 47 publications

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“…35 Briefly, equal amounts of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and PEG-6000 (or SA) were added into 5 mL dimethyl sulfoxide, and the solution was stirred for 3 hours. Bio-SPIONs were added to the activated linker (PEG or SA) and stirred continuously for 48 hours.…”

Section: Surface Engineering Through Carbodiimide Chemistrymentioning

confidence: 99%

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, T2 relaxometry, and photodynamic treatment potential

Bano¹,

Nazir²,

Nazir³

et al. 2016

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have the potential to be used as multimodal imaging and cancer therapy agents due to their excellent magnetism and ability to generate reactive oxygen species when exposed to light. We report the synthesis of highly biocompatible SPIONs through a facile green approach using fruit peel extracts as the biogenic reductant. This green synthesis protocol involves the stabilization of SPIONs through coordination of different phytochemicals. The SPIONs were functionalized with polyethylene glycol (PEG)-6000 and succinic acid and were extensively characterized by X-ray diffraction analysis, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, Rutherford backscattering spectrometry, diffused reflectance spectroscopy, fluorescence emission, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, and magnetization analysis. The developed SPIONs were found to be stable, almost spherical with a size range of 17–25 nm. They exhibited excellent water dispersibility, colloidal stability, and relatively high R 2 relaxivity (225 mM −1 s −1 ). Cell viability assay data revealed that PEGylation or carboxylation appears to significantly shield the surface of the particles but does not lead to improved cytocompatibility. A highly significant increase of reactive oxygen species in light-exposed samples was found to play an important role in the photokilling of human cervical epithelial malignant carcinoma (HeLa) cells. The bio-SPIONs developed are highly favorable for various biomedical applications without risking interference from potentially toxic reagents.

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Section: Surface Engineering Through Carbodiimide Chemistrymentioning

confidence: 99%

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, T2 relaxometry, and photodynamic treatment potential

Bano¹,

Nazir²,

Nazir³

et al. 2016

IJN

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“…All of these biomedical applications require the nanoparticles to have high magnetization values and hydrophilic surface and also nontoxicity and biocompatibility [5,6].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis and Special Phase Transformation of Hydrophilic Iron Oxides Nanoparticles

Chen

Long

Leng

et al. 2017

Journal of Nanomaterials

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Superparamagnetic iron oxide nanoparticles (SPIONs), -Fe 2 O 3 , with hydrophilic surfaces are fabricated in ethylene glycol solutions, without surfactant or additive, by solvothermal process from -Fe 2 O 3 nanoparticle as precursors. With the addition of a trace of hydrazine hydrate, the cubic phase Fe 3 O 4 nanoparticles are obtained instead of -Fe 2 O 3 . The saturation magnetization value of -Fe 2 O 3 nanoparticles is up to 74.3 emu/g. This study provides a low cost, safe, and universal route to serve as excellent biocompatibility magnetic core for future applications in biomedical, agriculture, and horticulture applications.

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“…Polyethyleneimine (PEI) is one of the more used ligands. 49 The same group 50,51 has reported that hyaluronic acid targeted iron oxide nanoparticles are efficient probes for targeted MRI of cancer cells in vitro and xenografted tumor model in vivo. Other types of ligands have been studied for the targeting of such markers including antibodies, small peptides, lectins, aptamers, engineered proteins, and protein fragments.…”

mentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications

Cited by 284 publications

References 47 publications

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, <em>T</em><sub>2</sub> relaxometry, and photodynamic treatment potential

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, <em>T</em><sub>2</sub> relaxometry, and photodynamic treatment potential

Facile Synthesis and Special Phase Transformation of Hydrophilic Iron Oxides Nanoparticles

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

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