Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives

Highly Efficient Heterogeneous Copper-Catalysed Coupling of Oxime Acetates with Isothiocyanates Leading to 2-Aminothiazoles

“…First, the effect of various immobilised copper complexes on the model reaction was examined by using Cs 2 CO 3 as base and toluene as solvent at 110 °C and a significant catalytic effect was observed (Table 1, entries 1-7). It is evident that good yields were obtained when [13][14][15]. The control experiments showed that no desired product 3a was detected in the absence of a base or a copper catalyst (Table 1, entries 16 and 17).…”

“…12,13 Reactions starting directly from ketones and thioureas have also been reported for the synthesis of 2-aminothiazoles. [14][15][16] However, they suffer from some drawbacks such as harsh reaction conditions, poor functional group tolerance or limited starting materials. Therefore, the development of more green reagents and new efficient methods for the synthesis of 2-aminothiazoles is highly desirable.…”