Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex

Jin, Geng Bang; Chen, Hui

doi:10.1007/s41664-017-0021-9

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The preparation of the inclusion complexes was carried out using the freeze-drying method [ 38 ]. An appropriate amount of rutin was weighed and dissolved in a small amount of ethanol, and the same amounts of β-CD, HP-β-CD and DM-β-CD were weighed and dissolved in distilled water.…”

Section: Methodsmentioning

confidence: 99%

Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes

Chang

Song²,

Ma³

et al. 2023

Molecules

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Rutin is a natural flavonoid that carries out a variety of biological activities, but its application in medicine and food is limited by its water solubility. One of the classical methods used to enhance drug solubility is encapsulation with cyclodextrins. In this paper, the encapsulation of different cyclodextrins with rutin was investigated using a combination of experimental and simulation methods. Three inclusions of rutin/beta-cyclodextrin (β-CD), rutin/2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and rutin/2,6-dimethyl beta-cyclodextrin (DM-β-CD) were prepared by the freeze-drying method, and the inclusions were analyzed using Fourier infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), differential scanning calorimetry (DSC) and ultraviolet–visible spectroscopy (UV) to characterize and demonstrate the formation of the inclusion complexes. Phase solubility studies showed that rutin formed a 1:1 stoichiometric inclusion complex and significantly increased its solubility. β-CD, HP-β-CD, DM-β-CD, rutin and the three inclusion complexes were modeled by using MS2018 and AutoDock 4.0, and molecular dynamics simulations were performed to calculate the solubility parameters, binding energies, mean square displacement (MSD), hydrogen bonding and radial distribution functions (RDF) after the equilibration of the systems. The results of simulation and experiment showed that rutin/DM-β-CD had the best encapsulation effect among the three cyclodextrin inclusion complexes.

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Section: Methodsmentioning

confidence: 99%

Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes

Chang

Song²,

Ma³

et al. 2023

Molecules

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“…β-cyclodextrins are non-toxic macrocyclic oligosaccharides formed from 7 glucose molecules linked by α − 1, 4-glucoside bonds [3][4][5]. Cyclodextrins have annular or truncated conical shapes as a result of the absence of freely rotating links that connect the glucose-pyranose units.…”

Section: β-Cyclodextrinmentioning

confidence: 99%

Research and prospect of inclusion complexes of dexibuprofen -cyclodextrin

2023

TNS

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Dexibuprofen is an over-the-counter drug often used to relieve pain and reduce fever. However, dexibuprofen is less soluble in the gastrointestinal tract, resulting in a slower rate of absorption. In order to enhance the bioavailability, researchers have devised inclusion complexes including dexibuprofen and cyclodextrin. -cyclodextrin is a cyclic molecule characterized by its annular configuration and possesses a distinctive void structure that enables the entrapment of other molecules via an enveloping mechanism, ultimately leading to the formation of a robust inclusion complex. The incorporation of dexibuprofen into an inclusion complex resulted in enhanced stability, higher aqueous solubility, and improved oral bioavailability. Furthermore, the incorporation of the inclusion complex can potentially mitigate the gastric mucosa irritation caused by dexibuprofen and minimize the gastrointestinal tract's unfavorable effects via the inclusion combination. The inclusion complex of dexibuprofen and -cyclodextrin is a form of drug with improved solubility and bioavailability that has broad application prospects to provide more effective pain relief and fever treatment. This study focuses on the investigation of the preparation and identification of dexibuprofen clathrate through a comprehensive analysis of existing literature. The primary objective is to determine the most effective inclusion technique for dexibuprofen based on considerations of yield and clathrate rate. Additionally, the research article examined the methodology for the formulation of clathrate into dispersible tablets, along with an initial investigation into the pharmacokinetics of these tablets in rat models.

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Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex

Cited by 2 publications

References 21 publications

Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes

Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes

Research and prospect of inclusion complexes of dexibuprofen -cyclodextrin

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