Facile Synthesis and Self-Assembly of Amphiphilic Polyether-Octafunctionalized Polyhedral Oligomeric Silsesquioxane via Thiol-Ene Click Reaction

Abstract

We demonstrated here a facile and efficient synthesis of polyhedral oligomeric silsesquioxane-based amphiphilic polymer by thiol-ene click chemistry. The properties of polyhedral oligomeric silsesquioxane (POSS)–PEG amphiphilic polymers were studied in detail by a combination of 1H NMR, 13C NMR, 29Si NMR FT-IR, GPC, and TG analysis. The newly-designed thiol-ene protocol obtains only anti-Markovnikov addition POSS-based amphiphilic polymers when compared with platinum-catalysed hydrosilylation method. The critical micelle concentration (CMC) of the resulting polymers are in the range of 0.011 to 0.050 mg/mL, and dynamic light scattering (DLS) results revealed that the obtained amphiphilic polymers can self-assemble into nanoparticles in aqueous solutions with a bimodal (two peaks) distribution. Furthermore, the specific polymer showed obvious thermo-sensitive behaviour at 45.5 °C.

Single Functional Group Platform for Multistimuli Responsivities: Tertiary Amine for CO2/pH/ROS-Triggered Cargo Release in Nanocarriers

“…Smaller sizes for the assemblies from AB 2 polymer with a hydrophobic tertiary amine at the terminus of polycaprolactone (arm A) than the one without it, suggest tighter packing at the core in these systems. Next, CMC of MP1 and TA-MP2 were evaluated using pyrene, a classic fluorophore in such studies. − Upon introduction into bloodstream, NPs undergo extensive dilution, and low CMC is desired for formulation stability. The ratio of fluorescent intensities at 338 and 333 nm were calculated and the intersection at which a spike in intensity was seen was determined as the CMC (Figure S20).…”

Organic–Inorganic Hybrid Materials: Tailoring Carbon Dioxide-Based Polycarbonate with POSS-SH Crosslinking

“…According to the previously established literature [36][37][38], a synthesis was performed in a 1000 mL round-bottom flask, to which was added 500 mL of methanol (MeOH), 30 Scheme 1. Terpolymerization of AGE, PO, and CO 2 catalyzed by ZnGA.…”

Polyhedral Oligomeric Silsesquioxane Hybrid Polymers: Well‐Defined Architectural Design and Potential Functional Applications

“…Faruk et al have prepared miktoarm star‐shaped polymers (PCL) 8 ‐POSS‐(mPEG) 7 30 with a POSS core via a combination of CuAAC, ATRP, and ROP techniques . Xia et al have also prepared an amphiphilic star‐shaped POSS‐hybrid polymers POSS‐(PEG) 8 31 via the TEC reaction …”