Facile Synthesis of Substituted Quinazolin‐4‐(3H)‐ones Using Low‐Valence Titanium Reagent.

Abstract

Fused pyrimidine derivatives R 0515Facile Synthesis of Substituted Quinazolin-4-(3H)-ones Using Low-Valence Titanium Reagent. -A short and facile synthesis of 3-arylquinazolinones (III) (9 examples) under mild and neutral conditions via reductive coupling of N-aryl-2-nitrobenzamides (I) with triethyl orthoformate promoted by low-valent titanium reagent derived from TiCl4 and Zn is described. -(SHI*, D.; RONG, L.; WANG, J.; ZHUANG, Q.; WANG, X.; HU, H.; Synth.