Facteurs de risque des réactions anaphylactoïdes aux myorelaxants. Etude rétrospective à partir de 103 chocs

Moneret‐Vautrin, D.A.; Laxenaire, M; Boileau, S.; Grilliat, J.P.; Widmer, S.; Croizier, A.

doi:10.1016/s0750-7658(85)80191-x

Cited by 15 publications

(8 citation statements)

References 23 publications

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“…The percentage of positive skin test and positive Phadiatop was similar in both groups, whereas total IgE level was significantly higher in the case group. This striking predominance of women has also been noted in atiaphylactic reactions to most anaesthetic drugs (16,18). In allergy to muscle relaxants, Moneret-Vautrin et al (18) reported a higher prevalence of positive skin tests to common allergens in the case group.…”

Section: Discussionmentioning

confidence: 79%

“…IgE levels have been found higher in patients reporting allergy to penicillin (1) or anaesthetics (6). In allergy to muscle relaxants, Moneret-Vautrin et al (18) reported a higher prevalence of positive skin tests to common allergens in the case group. In a recent study (6), we compared skin tests to common aeroallergens, Phadiatop test and total IgE levels between 32 patients with a history of anaphylactic reactions to muscle relaxants and 128 control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…More specifically, it has been suggested that reactions to anaesthetic drugs could be more frequent in atopies (9,10,11,16,21). The relevance of atopic status as a risk factor for SR to drugs has even been considered in IgE-mediated drug reactions, such as to penicillin (20) or muscle relaxants (12,18). Thus, in epidemiological standardized questionnaires, drug allergy has sometimes been included as one of the possible signs of atopic status (19).…”

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confidence: 99%

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Atopy and systemic reactions to drugs

Haddi

Charpin

Tafforeau

et al. 1990

Allergy

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To elucidate whether systemic reactions (SR) to drugs should be included in the atopic status in epidemiological studies, we compared the distribution of atopy in subjects with or without a history of SR to drugs. The studied population comprised 2067 adults, 20 to 60 years old, visiting a health care center for a check-up examination. The protocol included a questionnaire related to history of SR to drugs and a Phadiatop test which evaluates on a blood sample the presence of specific IgE against common aeroallergens. Overall, 14.7% of the study group, including 66% women, reported reliable histories of SR to drugs. The cumulative prevalence of asthma, hay fever and childhood dermatitis was higher in the SR group. By contrast, the percentage of positive Phadiatop tests was similar in subjects with or without a history of SR. Thus atopy, defined by an objective criterion, i.e. the presence of specific IgE against common aero-allergens, is not associated with the occurrence of SR to drugs. Such a history should not be included as part of the atopic status.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Atopy and systemic reactions to drugs

Haddi

Charpin

Tafforeau

et al. 1990

Allergy

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“…Recently Moneret-Vautrin ^' r (7/. [14] found twice the number of positive skin tests to inhalant allergens in fifty-six patients who had suffered anaphylactic shock to muscle relaxants, compared toacontrot population of 10 159 subjects. However, the same protocol was not used in the control population as in the patient series.…”

Section: Predisposing Factorsmentioning

confidence: 99%

“…Thus for lack of precise epidemiological studies, the question of the possible role of atopy as a predisposing factor to allergy to muscle relaxants remains largely unanswered. Some French authors [14] have stressed other predisposing factors such as 'spasmophilia", increased reactivity to histamine and over-anxiety.…”

Section: Predisposing Factorsmentioning

confidence: 99%

Allergy to muscle relaxants and related compounds

Vervloët

1985

Clin Experimental Allergy

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Anaphylaxis and anaphylactoid reactions are well known side effects of the administration of muscle relaxants to patients undergoing general anaesthesia. Researchers have determined that quaternary ammonium ions on the muscle relaxant molecules bind to drug reactive IgE antibodies and this initiates the release of histamine from the leucocytes. The drug reactive IgE antibodies are not specific and cross react with other muscle relaxants, all of which possess quaternary ammonium ions.Although the mechanism of muscle relaxantinduced anaphylactoid reactions is becoming better understood, the reasons why only some people are allergic to muscle relaxants are not. Sensitisation may occur in patients who have undergone general anaesthesia on more than 1 occasion previously. Further, the presence of ammonium ions on molecules other than those of muscle relaxant drugs (such as vasodilators) may have caused sensitisation in some patients. As yet, the roles, if any, of atopy, spasmophilia, anxiety, gender and increased reactivity to histamine in predisposing patients to muscle relaxant-induced anaphylactoid reactions are largely undetermined.

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Epidemiology of Various Allergic Reactions

Vervloët

Charpin

1991

New Trends in Allergy III

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Facteurs de risque des réactions anaphylactoïdes aux myorelaxants. Etude rétrospective à partir de 103 chocs

Cited by 15 publications

References 23 publications

Atopy and systemic reactions to drugs

Atopy and systemic reactions to drugs

Allergy to muscle relaxants and related compounds

Epidemiology of Various Allergic Reactions

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