Factitious schizophrenia

Kumar, Suresh; Grover, Sandeep; Mattoo, Surendra Kumar; Painuly, NiteshPrakash; Bhateja, Gaurav; Kaur, Rajinder

doi:10.4103/0019-5545.55944

Cited by 12 publications

(12 citation statements)

References 15 publications

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“…After a thorough search in Medline, PubMed, Embase, Medknow databases, we came across a few case reports from India of varied presentations like factitious schizophrenia,[ 15 ] multiple physical and sexual complaints,[ 16 ] and oliguria,[ 17 ] whereas detailed case series and long-term studies are yet to be reported.…”

Section: Introductionmentioning

confidence: 99%

Factitious Disorder-Experience at a Neuropsychiatric Center in Southern India

Dahale¹,

Hatti²,

Thippeswamy³

et al. 2014

Indian Journal of Psychological Medicine

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Objective:Factitious disorder is amongst the more intriguing but less-studied psychological disorders. Studies from different parts of the world have reported of varying prevalence rates. Here, we try to study the prevalence of factitious disorder in a specific sample of patients attending a neuropsychiatric center in India.Materials and Methods:We did a retrospective review of our institute's database for cases with a diagnosis of factitious disorder in the 10-year duration from 2001 to 2010. We reviewed the available clinical and socio-demographic data.Results:Of the 81,176 patients seen in the 10-year duration, only 8 patients had been assigned the diagnosis of factitious disorder, leading to a prevalence rate of 0.985 per 10,000 patients in this sample. Most of the patients were lost to follow-up; hence.Conclusion:Factitious disorder remains highly underdiagnosed in developing countries like India. Mental health professionals need to be more aware and inquisitive about this particular disorder, so that they do not miss the diagnosis.

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Section: Introductionmentioning

confidence: 99%

Factitious Disorder-Experience at a Neuropsychiatric Center in Southern India

Dahale¹,

Hatti²,

Thippeswamy³

et al. 2014

Indian Journal of Psychological Medicine

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“…Knowledge on the disposition and absorption characteristics of SRT in animals can help to interpret results in humans, such as drug-drug interactions [21,22] and side effects [23][24][25], and to establish relationships between plasma concentrations and pharmacodynamics [26,27]. Thus, the potential hepatotoxicity of SRT has been associated with mitochondrial dysfunction in rats [28], and a rat model of Huntington's disease has been used to study the protective effect of orally administered SRT against induced cognitive dysfunction [29,30]. Pharmacokinetic studies relating administered doses with plasma levels obtained in rats could improve the extrapolation of results to humans, relating the observed effects to the SRT plasma levels rather than to the administered doses.…”

mentioning

confidence: 99%

Determination of sertraline in rat plasma by HPLC and fluorescence detection and its application to in vivo pharmacokinetic studies

Melis

Usach

Peris

2012

J of Separation Science

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A simple, rapid, and sensitive HPLC method based on 9H-fluoren-9-ylmethyl chloroformate derivatization for the quantification of sertraline in rat plasma has been developed, requiring a plasma sample of only 0.1 mL, which was deproteinized and derivatized for 5 min in two single steps. The obtained derivative was stable at room temperature and was determined by HPLC using a fluorescence detector. The analytical column was a C(18) column and the mobile phase was acetonitrile and water (80:20, v/v). Calibration curves were linear in the range of 10-500 ng/mL. The limit of detection was approximately 3 ng/mL, and the lower limit of quantification was established at 10 ng/mL. The bias of the method was lower than 10%, and the within day as well as between day, relative standard deviations were lower than 12%. This analytical method was successfully applied to characterize sertraline pharmacokinetics in rats following intravenous (t(1/2) = 213 ± 48 min, Cl = 43.1 ± 8.7 mL/min, V(d) = 11560 ± 1861 mL) and oral (C(max) = 156 ± 76 ng/mL, t(max) = 63.8 ± 16.3 min) administration of 2 and 5 mg, respectively.

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“…We are grateful to the authors of “factitious schizophrenia”[ 1 2 ] for having opened the Pandora's box again. A case report is to be presented on the basis of facts, logic and reason.…”

mentioning

confidence: 99%

“…There are certain fallacies inherent in their deductive and inductive reasoning. The patient's initial contact with the psychiatrist for depression, transient blindness (para 4, page 170)[ 1 ] and schizophrenia (para 6, page 169)[ 1 ] was at the age of 16 years. The diagnosis of schizophrenia was confirmed by the psychiatrist in the Department of Psychiatry, Pgimer0 (post graduate institute of medical education and research, Chandigarh), and treated for more than a year with antipsychotic drugs, i.e., Risperdone and Ziprasidone; whence, the patient developed left-sided gynecomastia.…”

mentioning

confidence: 99%

“…There is self-contradictory explanation regarding antipsychotic medication, its initiation and continuation for two years (para 3, page 203; para 2, page 204). [ 2 ] Patient had developed seizure at the age of 17 years (para 4, page 170),[ 1 ] which later turned out to be pseudoseizure,[ 3 ] not so uncommon presentation; up to 10% of cases with seizures disorder have feigned symptoms (para 9, page 170). [ 1 ] At the age of 18 years, patient reported to psychiatric emergency for attempted suicide, atypical features of depression, hopelessness and continuous auditory hallucinations (para 5, page 169).…”

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confidence: 99%

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