Factor structure of the Depression Anxiety Stress Scales in individuals with traumatic brain injury

Wong, Dana; Dahm, Jane Q; Ponsford, Jennie Louise

doi:10.3109/02699052.2013.823662

Cited by 27 publications

(20 citation statements)

References 15 publications

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“…Indeed, some studies found that such combination therapy reduced mortality, infarct size, and improved left ventricular function, accompanied by increased homing of bone marrow cells to the infarcted myocardium and formation of new cardiomyocytes and ventricular structures (21). In chronic stroke studies, G-CSF + SCF induced more stable and long-lasting functional improvement compared with treatment with SCF or G-CSF alone, attributable to increased angiogenesis and neurogenesis through bone marrow-derived cells and the direct effects on stimulating neurons to form new neuronal networks (126).…”

Section: Therapeutic Uses Of G-csfmentioning

confidence: 99%

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma. Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy. The efficacy of stem cell-based interventions, as well as neuroprotective agents in other neurological disorders of which pathologies overlap with TBI, indicates their potential as alternative TBI treatments. Furthermore, their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent. Indeed, we demonstrated remarkable combined efficacy of human umbilical cord blood (hUCB) cell therapy and granulocyte-colony-stimulating factor (G-CSF) treatment in TBI models, providing essential evidence for the translation of this approach to treat TBI. Further studies are warranted to determine the mechanisms underlying therapeutic benefits exerted by hUCB + G-CSF in order to enhance its safety and efficacy in the clinic.

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Section: Therapeutic Uses Of G-csfmentioning

confidence: 99%

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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“…In moderate to severe trauma, TBI survivors present with chronic disabilities associated with loss of primary cerebral parenchymal tissues, secondary cell death including apoptosis, and exacerbated neuroinflammation [9], [10], [11]. Among the worst outcomes, sensorimotor dysfunctions, massive hippocampal cell death, learning and memory impairments, aphasia, anxiety, and dementia are the most prevalent [12], [13], [14], [15], [16]. At present, clinical treatments are limited and the few that have been utilized have proven to be ineffective in most of the TBI cases [17], [18], [19].…”

Section: Introductionmentioning

confidence: 99%

Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury

et al. 2014

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Traumatic brain injury (TBI) is associated with neuro-inflammation, debilitating sensory-motor deficits, and learning and memory impairments. Cell-based therapies are currently being investigated in treating neurotrauma due to their ability to secrete neurotrophic factors and anti-inflammatory cytokines that can regulate the hostile milieu associated with chronic neuroinflammation found in TBI. In tandem, the stimulation and mobilization of endogenous stem/progenitor cells from the bone marrow through granulocyte colony stimulating factor (G-CSF) poses as an attractive therapeutic intervention for chronic TBI. Here, we tested the potential of a combined therapy of human umbilical cord blood cells (hUCB) and G-CSF at the acute stage of TBI to counteract the progressive secondary effects of chronic TBI using the controlled cortical impact model. Four different groups of adult Sprague Dawley rats were treated with saline alone, G-CSF+saline, hUCB+saline or hUCB+G-CSF, 7-days post CCI moderate TBI. Eight weeks after TBI, brains were harvested to analyze hippocampal cell loss, neuroinflammatory response, and neurogenesis by using immunohistochemical techniques. Results revealed that the rats exposed to TBI treated with saline exhibited widespread neuroinflammation, impaired endogenous neurogenesis in DG and SVZ, and severe hippocampal cell loss. hUCB monotherapy suppressed neuroinflammation, nearly normalized the neurogenesis, and reduced hippocampal cell loss compared to saline alone. G-CSF monotherapy produced partial and short-lived benefits characterized by low levels of neuroinflammation in striatum, DG, SVZ, and corpus callosum and fornix, a modest neurogenesis, and a moderate reduction of hippocampal cells loss. On the other hand, combined therapy of hUCB+G-CSF displayed synergistic effects that robustly dampened neuroinflammation, while enhancing endogenous neurogenesis and reducing hippocampal cell loss. Vigorous and long-lasting recovery of motor function accompanied the combined therapy, which was either moderately or short-lived in the monotherapy conditions. These results suggest that combined treatment rather than monotherapy appears optimal for abrogating histophalogical and motor impairments in chronic TBI.

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“…This scale was first introduced in 1995 by Lovibond (27) and ever since is used in various foreign studies (28)(29)(30). The reliability and validity of this scale is confirmed for patients with MS in Iran (r = 0.89) (31).…”

Section: Questionnairementioning

confidence: 99%

Pelvic Floor Muscle Training Instruction to Control Urinary Incontinence and its Resulting Stress, Anxiety and Depression in Patients with Multiple Sclerosis

Rafii

Sajjadi

Shareinia

et al. 2016

Jundishapur J Chronic Dis Care

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Background: Urinary disorders are common problems in patients with multiple sclerosis (MS). Urinary incontinence largely affects the physical, social and emotional characteristics and activities of such patients. Objectives: The current study aimed to identify the effect of pelvic floor muscle training on urinary incontinence and its resulting stress, anxiety and depression in patients with MS. Methods: The present clinical trial with a pre-post design was conducted on 50 patients with MS referring to the MS clinic of Imam Khomeini hospital in Tehran, Iran, selected by convenience sampling method. Participants received instructions on pelvic floor muscle exercises and then practiced for three consecutive months. The international consultation on incontinence questionnaireurinary incontinence short form (ICIQ-UI-SF) was used to measure participants' urinary incontinence, and the 21-item depression, anxiety and stress scale (DASS-21) to measure their depression, anxiety and stress, both before the intervention and at the end of the third month of exercising. The obtained data were analyzed by SPSS16 using descriptive statistics and the dependent t test. Results: About 45 (90%) participants practiced pelvic floor muscle exercises until the end of the third month. The frequency and amount of urine leakage and the effect of urinary incontinence on the quality of life differed significantly in the patients after the instructions compared to the status before the intervention (P < 0.001). The mean score of stress (P < 0.001), anxiety (P = 0.04) and depression (P = 0.003) decreased significantly after the intervention. Conclusions: According to the findings, instructing pelvic floor muscle exercises was effective in reducing urinary incontinence and its resulting stress, anxiety and depression in patients with MS. These exercises were recommended as a non-pharmacological, non-invasive and cost-effective method to control urinary incontinence in patients with MS.

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Factor structure of the Depression Anxiety Stress Scales in individuals with traumatic brain injury

Abstract: These results indicate that it may be preferable to use the full DASS, rather than the DASS21, with individuals with TBI.

Cited by 27 publications

References 15 publications

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury

Pelvic Floor Muscle Training Instruction to Control Urinary Incontinence and its Resulting Stress, Anxiety and Depression in Patients with Multiple Sclerosis

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