Factor VII Deficiency and Pregnancy: Case Report and Review of Literature

Abstract

Inherited factor VII de ciency is an autosomal recessive coagulation disorder with broad range of bleeding manifestations. The association between bleeding and absolute factor VII level is poor. Usually, the bleeding is associated with FVII levels of less than 1% of the normal value. Factor VII de ciency is associated with prolongation of prothrombin time only with normal activated partial thromboplastin time.Approximately 66 pregnant women have been reported with factor VII de ciency so far in English literature.We hereby, report 2 cases along with the review of literature of Factor VII de ciency during pregnancy. Our patients were diagnosed to have factor VII de ciency after deranged coagulogram with factor VII level of < 1% and 17.1% respectively, however could be managed by fresh frozen plasma only in rst case and fresh frozen plasma & factor VII concentrate in second case successfully. Coagulogram is a simple, easily available, affordable and lifesaving investigation to detect this de ciency in pregnancy.