Introduction: Musculoskeletal disorders are ailments caused by adopting incorrect positions and adjusting to them. These issues are prevalent in work environments, particularly in crucial health regions where nursing professionals work. Poor posture can hinder physical performance and impair the health of the professional. Objective: This study aims to evaluate the results of published studies concerning factors associated with musculoskeletal disorders among nurses working in critical care services. Materials and Methods: A systematic review of the literature using a narrative approach was conducted by searching databases such as PubMed, Science Direct, Google Scholar, and the Scielo Electronic Library in Portuguese, English, and Spanish. This was based on the proposal of the PRISMA declaration for systematic reviews and registered in the PROSPERO database (CRD 42023485858). Results: The initial search generated 58 primary reviews, from which 27 met the inclusion and quality standards. The average age of the population ranged from 31 to 35 years, female sex, with a bachelor’s degree academic level and less than 10 years of professional experience. The most affected body parts were the lumbar region, neck, and shoulders. Concerning the associated factors, there was a higher prevalence of disorders due to repetitive mechanical movements and deficits in the use of body mechanics. Conclusions: National strategies or public health policies need to be developed to promote the prevention and control of musculoskeletal disorders among nursing staff. These strategies should be built on scientific research about such diseases and daily nursing practices.