Factorial design for the analysis of patient’s quality of life in asthma

Abstract

Chronic diseases like asthma have a great impact on the everyday life of patients. Evaluation of a patient's quality of life informs us about how the patient is feeling and whether or not he or she is able to function physically, socially and emotionally. The objectives of this study were to assess the quality of life of asthmatic patients and to study the influence of age and disease severity, as independent variables, on the patient's quality of life. A 2-factor, 3-level face-centred central composite design was applied to construct a second-order polynomial model describing the effects of age and the severity on the quality of life. The second-order polynomial model was successfully applied to describe the effect of age and asthma severity with good correlation on the quality of life measured by either generic (Visual analogue scale) or disease specific (St George's Respiratory Questionnaire) instruments in the examined subjects. Our findings suggest quality of life may be used as a non-invasive patient-centred monitoring system as a guide for disease management if measured regularly.

Health-related quality of life assessment using St. George′s respiratory questionnaire in asthmatics on inhaled corticosteroids

“…Baseline SGRQ scores in our study population was higher compared to baseline scores of other asthma studies where the SGRQ was the QoL instrument[13] possibly due to our subjects being treatment naïve. After treatment with ICS, there was a significant decrease ( P < 0.05) in SGRQ scores reflecting improved QoL in all three-treatment groups.…”

“…[2] QoL unique to each individual is influenced by the perception of disease. [3] Current clinical guidelines recommend inhaled corticosteroids (ICS) as the mainstay of therapy in chronic asthma. [4]…”

Calidad de Vida y Factores Biopsicosociales en Patologías Médicas Crónicas

“…Este hallazgo reafirma la gran mayoría de las investigaciones que han reportado que la edad no es una variable influyente en la CV, sin embargo, en patologías específicas, algunos autores han encontrado alguna relación, como por ejemplo, menor CV en mujeres con diabetes de mayor edad (Mata, 2003), peor CV en pacientes más jóvenes viviendo con VIH (Swindells, 1999), personas con asma (Mészáros et al, 2005), pacientes dializados (Pucheu et al, 2004) o con las dimensiones física y social en el caso de la edad y sexo para personas viviendo con Parkinson (Frazier, 2000).…”

“…Puede que dada la baja gravedad de los síntomas en nuestra muestra, así como el buen control de los mismos bajo una correcta medicación, tengan un grado de influencia en este dato, ya que algunos autores han encontrado vinculación entre esta variable y la CV (Mészáros et al, 2005;Frazier, 2000). En este sentido, para Arnold et al (2004), las diferencias entre enfermedades pueden deberse a que diferentes dominios específicos son afectados de forma diferente en cada enfermedad y por ende, la contribución de cada dominio específico a la calidad de vida general también varía.…”

Reliability and validity of the Assessment of Quality of Life in Asthma Patients (QLQ‐Asthma) in a sample of adult asthmatic patients in Turkey

“…Chronic diseases like asthma have a great impact on the everyday life of patients. Evaluation of a patient's QoL informs us about how the patient is feeling and whether or not he or she is able to function physically, socially and emotionally (Blaiss 1997, Meszaros et al 2005. People with severe asthma are suffering symptoms that have a significant impact on their home and work life.…”