Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles

Dillen, Kathleen; Vandervoort, Jo; Mooter, Guy Van den; Verheyden, Loes; Ludwig, Annick

doi:10.1016/j.ijpharm.2004.01.033

Cited by 159 publications

(98 citation statements)

References 35 publications

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“…Size exclusion chromatography [58][59][60] Surface chemistry analysis X-ray photoelectron spectroscopy 28,61,62 Fourier transform infrared spectroscopy 54,63,64 Nuclear magnetic resonance spectroscopy [64][65][66] Surface charge Zetasizer 56,67,68 Crystallinity X-ray diffraction 37,69,70 Differential scanning calorimetry [71][72][73] Hydrophobicity, hydrophilicity water contact angle measurements 65,74,75 Hydrophobic interaction chromatography [76][77][78] Drug entrapment efficiency, drug release studies…”

Section: Molecular Weightmentioning

confidence: 99%

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

396

265

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The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.

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Section: Molecular Weightmentioning

confidence: 99%

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

396

265

View full text Add to dashboard Cite

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“…Preparation of amikacin sulphate-loaded Eudragit Ò RS 100/RL 100 nanoparticles Nanoparticles were prepared by w/o/w emulsification solvent evaporation approach immediately succeeded by highpressure homogenization (Dillen et al 2004). Keeping drug constant at 250 mg and varying polymer concentration, distinct ratios of drug and polymer were utilized for the preparation of nanoparticles.…”

Section: Optimization Of Polymer Proportion and Sonication Periodmentioning

confidence: 99%

In vitro, in vivo and pharmacokinetic assessment of amikacin sulphate laden polymeric nanoparticles meant for controlled ocular drug delivery

et al. 2014

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The rationale of current exploration was to formulate positively charged amikacin-loaded polymeric nanoparticles providing a controlled release attribute. Amikacin sulphate-loaded nanoparticles were prepared by w/o/w emulsification solvent evaporation approach succeeded by high-pressure homogenization. Two bioadhesive positively charged polymers, Eudragit Ò RS 100 and Eudragit Ò RL 100, were used in the blend, with variable ratios of drug and polymer. The formulations were assessed in terms of particle size and zeta potential. Thermal gravimetric analysis was brought out on the samples of drug, polymer and drug polymer complex. Drug loading and release attributes of the nanoparticles were scrutinized and antimicrobial activity in contrast to Staphylococcus aureus was appraised. Ocular irritation test, in vivo ocular retention study, in vivo release profile (permeation study) and in vivo antibacterial activity of polymeric nanosuspensions were executed. No rupture consequence but a lengthened drug release was contemplated from all formulations. Amikacin sulphate release from the polymeric nanoparticles reflected a better fit with Korsmeyer-Peppas model. In the course of the antibacterial activity of nanoparticles against S. aureus, formulation AE1 displays the most prominent inhibitory effect as compared with marketed formulation of amikacin sulphate.

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“…Many polymeric matrix materials have been intensively investigated in this context, including poly(D,L-lactic-co-glycolic acid) (P, PLGA) (Dillen et al, 2004;Fonseca et al, 2002;Govender et al, 1999;Lemoine and Préat, 1998;Nafee et al, 2007), chitosan (Janes et al, 2001;Prabha et al, 2002;Rhim et al, 2006), poly-ɛ-caprolactone (Gan et al, 1999;LeroueilLe Verger et al, 1998), starch (Kreuter, 1991;Le Corre et al, 2010), alginate (Johnson et al, 1997;Sarmento et al, 2006) and gelatin (Balthasar et al, 2005;Khan and Schneider, 2013;Truong-Le et al, 1999). One of the most common biodegradable and biocompatible polymers (Langer and Peppas, 1981) used to prepare NPs for the encapsulation of proteins, via the waterin-oil-in-water (w/o/w) double emulsion method, is PLGA.…”

Section: Introductionmentioning

confidence: 99%

Impact of PEG and PEG- b -PAGE modified PLGA on nanoparticle formation, protein loading and release

Rietscher

Czaplewska

Majdanski

et al. 2016

International Journal of Pharmaceutics

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Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles

Cited by 159 publications

References 35 publications

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

In vitro, in vivo and pharmacokinetic assessment of amikacin sulphate laden polymeric nanoparticles meant for controlled ocular drug delivery

Impact of PEG and PEG- b -PAGE modified PLGA on nanoparticle formation, protein loading and release

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