Factors affecting maximal acid secretion

Abstract

SummaryThe mechanisms by which different factors affect the maximal acid secretion of the stomach are discussed with particular reference to nationality, sex, age, body weight or lean body mass, procedural details, mode of calculation, the nature, dose and route of administration of a stimulus, the synergistic action of another stimulus, drugs, hormones, electrolyte levels, anaemia or deficiency of the irondependent enzyme system, vagal continuity and parietal cell mass.

Body weight and maximal acid outputPart of the work was supported by a grant from TNMC and BYL Nair Charitable Hospital Research Society.

“…The difficulty of estimating MAO accurately in all individuals with 004 mg/kg body weight of HAP was recently emphasized (Desai, 1969;Stempien, 1970) as subjects weighing less than 60 kg receive a submaximal stimulus (Desai, Borkar & Jeejeebhoy, 1967a) while those weighing 80 kg or more may perhaps receive a supramaximal stimulus causing a partial reduction of acid output . In the present study, dose-response curves were hence performed to obtain MAO accurately in each individual.…”