Factors Affecting Plaque Formation by the Infectious Ribonucleic Acid of the Equine Encephalitis Viruses

Infectivity of Nucleic Acid and Adsorptive Properties of Venezuelan Encephalitis Virions Inactivated by Lipid Solvents

“…Inactivation was clearly not due to a direct effect of SDC, diethyl ether, or chloroform on VE IRNA because when phenol-extracted IRNA from CEC viral suspensions was exposed to inactivating concentrations of SDC, ether, and chloroform, its infectivity titer, measured in hypertonic solution, remained unchanged (Table IV) like IRNA from other arboviruses (5,6,14,15). Inactivation was clearly not due to a direct effect of SDC, diethyl ether, or chloroform on VE IRNA because when phenol-extracted IRNA from CEC viral suspensions was exposed to inactivating concentrations of SDC, ether, and chloroform, its infectivity titer, measured in hypertonic solution, remained unchanged (Table IV) like IRNA from other arboviruses (5,6,14,15).…”