Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Verma, Rahul; Kandwal, Abhishek; Negi, Gita; Chandra, Harish

doi:10.1097/jbr.0000000000000091

Cited by 4 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Verma et al found no significant associations between age, gender and platelet count and growth factors concentration (23). Their results were similar to Cho (24), Dragoo (25) and Arun (26).…”

Section: Discussionsupporting

confidence: 55%

Factors Affecting Platelet Count in Platelet-Rich Plasma

SARI

2022

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Introduction: The amount of platelet count in platelet-rich plasma (PRP) is very important for the concentration of growth factors, which play a major role in the effectiveness of PRP. Aim: The aim of this study was to investigate the effects of demographic and clinical parameters on the number of platelets in PRP. Materials And Methods: The data of 50 patients who received PRP in our stem cell center were scanned retrospectively in electronic environment. Demographic and clinical parameters (age, gender, body mass index, blood group, comorbidities, hypertension, coronary heart disease and diabetes, alcohol and cigarette usage) of the patients were recorded. Results: The results of the correlation analysis performed to evaluate whether there was a relationship between age and BMI with regards to platelet count in PRP revealed no statistical significance (p>0.05). Analysis of Mann Whitney-U and Kruskal Wallis-H showed that there was a statistically significant difference in terms of platelet count, gender, presence of hypertension and coronary artery disease (p

show abstract

Section: Discussionsupporting

confidence: 55%

Factors Affecting Platelet Count in Platelet-Rich Plasma

SARI

2022

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

show abstract

“…It was reported that keeping the platelet distribution width within the normal ranges indicates good viability of the platelets. 39 Analysis showed that the platelet distribution width was within the physiological reference ranges, and the PRP procedure in this study did not cause preactivation of the platelets. Verma et al 39 emphasized that the platelet distribution width analysis may serve as a measure of quality for PRP activation.…”

Section: Discussionsupporting

confidence: 51%

“… 37 , 38 Higher platelet concentrations may not directly indicate a high-quality PRP alone. 39 On the contrary, over-concentrating platelets with increased growth factor concentrations do not enhance the regenerative properties of PRP and may delay the natural healing process by causing increased scar tissue formation. 40 , 41 …”

Section: Discussionmentioning

confidence: 99%

“…This is an expected result and well-documented in previous literature; however, the magnitude of this correlation may be an indicator for the platelet recovery rate from the baseline whole blood. 39 , 42 , 43 Platelet recovery rate represents the efficiency and quality of the PRP preparation process. 20 Significant correlations between platelet counts of whole blood and PRP were reported by Verma et al 39 ( r = 0.62) and Weibrich et al 42 ( r = 0.73), previously.…”

Section: Discussionmentioning

confidence: 99%

“… 39 , 42 , 43 Platelet recovery rate represents the efficiency and quality of the PRP preparation process. 20 Significant correlations between platelet counts of whole blood and PRP were reported by Verma et al 39 ( r = 0.62) and Weibrich et al 42 ( r = 0.73), previously. In this study, the results indicated a positive strong correlation ( r = 0.81) and 77% platelet recovery rate.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Factors affecting the features of platelet-rich plasma in patients with knee osteoarthritis

Argut,

Celik,

Ergin

et al. 2023

AOTT

View full text Add to dashboard Cite

Objective: The aim of this study was to present an analysis of platelet-rich plasma obtained from patients with knee osteoarthritis and reveal the factors affecting its features. Methods: A total of 62 patients (mean age: 56.68 ± 7.13 years) with symptomatic knee osteoarthritis were included in this study. Age (years), gender, height (m), weight (kg), body mass index (kg/m 2 ), duration of symptoms, smoking status, smoking index, general health status, and physical activity scores were recorded. Whole blood and platelet-rich plasma cell counts were performed with a hematology analyzer. White blood cell, red blood cell, and platelet counts were recorded. According to the dose of injected platelets, efficiency of the procedure, purity of platelet-rich plasma, and activation classification, dose of platelets, efficiency of the procedure (platelet recovery rate, %), and purity of the obtained platelet-rich plasma product (relative composition in platelets, %) were calculated. Correlation analysis between the features of platelet-rich plasma and the patient-related variables, including age, gender, body mass index, smoking status, smoking index, presence of other health conditions, physical activity scores, duration of symptoms, and pain levels, was performed. Results: Dose of injected platelets, efficiency of the procedure, purity of platelet-rich plasma, and activation analysis showed that the dose of injected platelets was 3.25 billion, the efficiency of the process was 77%, and the purity rate of the platelet-rich plasma was 98.4%. Platelet-rich plasma platelet count was correlated with whole blood platelet count ( r = 0.81, P < .001), whole blood white blood cell count ( r = 0.39, P = .002), smoking status ( r = 0.56, P = .03), smoking index ( r = −0.63, P = .002), and the presence of hypertension ( r = −0.31, P = .04). Platelet-rich plasma white blood cell and purity of platelet-rich plasma were correlated with the smoking status of the patients ( r = 0.52, P = .01; r = 0.64, P = .003, respectively). Conclusion: This study has demonstrated that high dose and very pure platelet-rich plasma with medium efficiency was yielded with this platelet-rich plasma preparation procedure; whole blood platelet count, the presence of hypertension, and the smoking status of patients affect the features of the obtained platelet-rich plasma. Level of Evidence: Level IV, Diagnostic Study.

show abstract

Current Challenges in the Development of Platelet‐Rich Plasma‐Based Therapies

Mercader-Ruiz,

Beitia,

Delgado

et al. 2024

BioMed Research International

View full text Add to dashboard Cite

Nowadays, biological therapies are booming and more of these formulations are coming to the market. Platelet‐rich plasma, or PRP, is one of the most widely used biological therapies due to its ease of obtention and autologous character. Most of the techniques to obtain PRP are focusing on new processes and methods of optimization. However, not enough consideration is being given to modify the molecular components of PRP to generate more effective formulations with the aim of improving PRP treatments. Therefore, this review covers different novel PRP‐obtaining methods that attempt to modify the molecular composition of the plasma.

show abstract

Factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB: an observational study

Cited by 4 publications

References 25 publications

Factors Affecting Platelet Count in Platelet-Rich Plasma

Factors Affecting Platelet Count in Platelet-Rich Plasma

Factors affecting the features of platelet-rich plasma in patients with knee osteoarthritis

Current Challenges in the Development of Platelet‐Rich Plasma‐Based Therapies

Contact Info

Product

Resources

About