Factors associated with aortic root dilatation after surgically repaired ventricular septal defect

Objective: The purpose of this study is to assess the mid-term outcomes of aortic root replacement after repair of CHDs. Method: This is a single-institutional retrospective, cohort study with consecutive patients undergoing aortic root replacement after surgical repair of CHDs between 1999 and 2022. Operative indications included aortic root dilatation with/without aortic insufficiency, sinus of Valsalva rupture, or aortic dissection involving the root. Results: Forty-four patients (36 male and 8 female) were enrolled. Mean age at the root replacement was 36.6 ± 11.9 years. The most frequent primary diagnosis was congenital aortic stenosis (n = 10) and ventricular septal defect (n = 10). Mean time from the surgical repair to aortic root replacement was 26.6 ± 13.0 years. Operative indications were aortic root enlargement with or without aortic valve aetiology (n = 40), sinus of Valsalva rupture (n = 2), and aortic dissection (n = 2). Forty-two patients underwent valve-replacing aortic root replacement, and two patients underwent valve-sparing, with 40 concomitant procedures. The median follow-up was 3.5 (1.3–7.6) years. There were one early and five late mortalities and five cardiovascular-related reoperations. Actuarial survival at 5–10 years after root replacement was 81.0 ± 6.6%. The cumulative incidence of cardiovascular-related reoperation and aortic root or valve-related reoperation at 5 years after root replacement was 11.9% and 5.6%, respectively. Conclusion: The early and mid-term outcomes of aortic root replacement for patients with a history of repair of CHDs were favourable in terms of survival and aortic root or valve-related reoperation.

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Factors associated with aortic root dilatation after surgically repaired ventricular septal defect

Cited by 3 publications

References 46 publications

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ISL1 loss-of-function mutation contributes to congenital heart defects

Association of aortic root dilatation with left ventricular function in patients with postoperative ventricular septal defect

The mid-term outcomes of aortic root replacement after surgical repair for CHD

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