Factors Associated with Bacteriological Cure After Dry Cow Treatment of Subclinical Staphylococcal Mastitis with Antibiotics

Sol, J.; Sampimon, O.C.; Snoep, J. J.; Schukken, Y.H.

doi:10.3168/jds.s0022-0302(94)76930-7

Cited by 47 publications

(48 citation statements)

References 3 publications

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“…Much research on cow-level factors and the probability of cure for clinical mastitis cases has been focused on S aureus. [16][17][18] The findings of these studies were summarized by Barkema and colleagues. 19 Increasing parity, elevated SCC before treatment, and having multiple quarters affected were associated with a decreased probability of cure.…”

Section: Case Selection-to Treat or Not To Treat?mentioning

confidence: 93%

Treatment of Mastitis in Cattle

Royster

Wagner

2015

Veterinary Clinics of North America: Food Animal Practice

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Section: Case Selection-to Treat or Not To Treat?mentioning

confidence: 93%

Treatment of Mastitis in Cattle

Royster

Wagner

2015

Veterinary Clinics of North America: Food Animal Practice

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“…These are the long term infected animals, in Figure 11 these are the animals in the upper right hand corner. A number of these animals may be eligible for treatment, especially valuable young animals with a relative short duration of infection should be considered [52,53].…”

Section: Curementioning

confidence: 99%

Monitoring udder health and milk quality using somatic cell counts

et al. 2003

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-In this article the use of somatic cell counts for monitoring udder health and milk quality is discussed. Somatic cell count dynamics at quarter, cow, herd and population level are discussed and illustrated with examples. Quarter and cow somatic cell counts directly represent the inflammatory status of the mammary gland. Herd and population somatic cell count are related to the inflammatory process in individual cows but much more reflect the udder health status of the herd and the quality of the raw milk in the herd and the population. Application of monitoring tools in herd health management are illustrated using a case study. Understanding infection dynamics requires precise longitudinal data. Monitoring tools are required to find the areas of risk in the herd. It is inevitable that more complete udder health programs and monitoring systems are to be developed and implemented. These programs are necessarily dynamic and complex. Implementation of complete udder health programs should be accompanied by research efforts to further fine-tune these complete udder health control and monitoring programs. somatic cell count / mastitis / milk quality / monitoring / epidemiology

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“…1999). Cure rates for antibiotic treatment of S. aureus IMI may range from 20% to 78% (Sol et al. 1994; Osteras et al.…”

Section: Introductionmentioning

confidence: 99%

Bovine whey proteins inhibit the interaction of Staphylococcus aureus and bacteriophage K

et al. 2006

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Aims: To understand the potential use of bacteriophage K to treat bovine Staphylococcus aureus mastitis, we studied the role of whey proteins in the inhibition of the phage–pathogen interaction in vitro. Methods and Results: The interaction of bacteriophage K and S. aureus strain Newbould 305 was studied in raw bovine whey and serum. Incubation of S. aureus with phage in whey showed that the bacteria are more resistant to phage lysis when grown in whey and also bovine serum. Whey collected from 23 animals showed a wide variation in the level of phage‐binding inhibition. The role of the protein component of milk whey in this inhibition was established; treatment of the whey by heat, proteases and ultrafiltration removed the inhibitory activity. Brief exposure of S. aureus cells to whey, followed by resuspension in broth, also reduced phage binding. Microscopy showed the adhesion of extracellular material to the S. aureus cell surface following exposure to whey. Chromatographic fractionation of the whey demonstrated that the inhibitory proteins were present in the high molecular weight fraction. Conclusions: The adsorption of whey proteins to the S. aureus cell surface appeared to inhibit phage attachment and thereby hindered lysis. The inhibitory whey proteins are of high molecular weight in their native form and may sterically block phage attachment sites on the cell surface. Significance and Impact of the Study: These findings have implications for any future use of phage therapy in the treatment of mastitis, and other diseases, caused by S. aureus. This pathogen is predicted to be much more resistant to phage treatment in vivo than would be expected from in vitro broth culture experiments.

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Factors Associated with Bacteriological Cure After Dry Cow Treatment of Subclinical Staphylococcal Mastitis with Antibiotics

Cited by 47 publications

References 3 publications

Treatment of Mastitis in Cattle

Treatment of Mastitis in Cattle

Monitoring udder health and milk quality using somatic cell counts

Bovine whey proteins inhibit the interaction of Staphylococcus aureus and bacteriophage K

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