Factors Associated with Bacteriological Cure During Lactation After Therapy for Subclinical Mastitis Caused by Staphylococcus aureus

Sol, J.; Sampimon, O.C.; Snoep, J. J.; Schukken, Y.H.

doi:10.3168/jds.s0022-0302(97)76243-x

Cited by 109 publications

(138 citation statements)

References 8 publications

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“…Penicillin resistance is generally associated with decreased Staph. aureus cure rates (Sol et al, 1997;Barkema et al, 2006), but a relatively high cure rate for penicillin-resistant strains was observed in our study on early treatment of Staph. aureus mastitis (van den Borne et al, 2010).…”

Section: Discussionmentioning

confidence: 90%

“…Our results suggest that determination of Staph. aureus host adaptation has value in predicting bacteriological cure after antimicrobial treatment during lactation and could be used to guide treatment and management decisions in dairy practice, together with information on cow characteristics (Sol et al, 1997;Deluyker et al, 2005;Barkema et al, 2006;Sandgren et al, 2008). Specifically, to achieve good probabilities of cure, treatment duration for bovine-associated strains may need to be longer compared with that for nonbovine-associated strains.…”

Section: Discussionmentioning

confidence: 99%

“…aureus subclinical mastitis (SCM) with antimicrobials has been advocated as a means to cure a cow and to decrease infectious pressure within the herd (Barkema et al, 2006). Results of treatment are highly variable in dairy practice and generally disappointing (Sol et al, 1997;Deluyker et al, 2005;Sandgren et al, 2008), although early detection and treatment of Staph. aureus SCM seems to improve the probability of cure (Barkema et al, 2006;van den Borne et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Borne

Nielen

Schaik

et al. 2010

Journal of Dairy Science

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Staphylococcus aureus causes a wide range of diseases in multiple species. Some sequence types (ST) are observed in a variety of hosts, whereas other strains are mainly associated with bovine mastitis, suggesting host adaptation. We propose that host adaptation of Staph. aureus may influence bacteriological cure of bovine subclinical mastitis after antimicrobial treatment. To test this hypothesis, multilocus sequence typing was performed on Staph. aureus isolates from 60 treated and 79 untreated control quarters that were obtained from well-defined cohorts of dairy cows from a recently conducted randomized field trial on early treatment of subclinical mastitis. Bovine-associated ST were distinguished from non-bovine-associated ST based on the literature and public databases. The association between host adaptation and bacteriological cure was investigated using population-averaged logistic regression models. Thirteen ST were identified, with approximately 80% of isolates belonging to bovine-associated ST. The odds for cure were around 2.5 times as high for non-bovine-associated ST as for bovine ST in treated quarters, whereas no difference in spontaneous cure was observed in untreated control quarters. In addition, host adaptation was related to known predictors of cure, such as penicillin susceptibility and somatic cell count. All isolates belonging to non-bovine-associated ST were resistant to penicillin, whereas the majority of isolates belonging to bovine-associated ST were penicillin susceptible. Penicillin-resistant bovine-associated strains were associated with high somatic cell counts compared with other strains. The correlation between penicillin resistance, cell counts, and host adaptation may affect the association between host adaptation and cure. For diagnostic purposes, a simple and fast alternative to multilocus sequence typing of Staph. aureus to determine host adaptation may be valuable.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Borne

Nielen

Schaik

et al. 2010

Journal of Dairy Science

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“…Such residues may be detrimental to the manufacture of certain cultured milk products, and antibiotic use in animal production contributes to microbe resistance (Belschner et al 1996;Kirk et al 2002;Oliver et al 1992). A wide range of alternatives to antibiotics have emerged as a result of their ban (organic acids, probiotics, herb extracts, and others), of which passive immunization with antibodies is an approach with great potential due to its high specificity (Sol et al 1997). …”

Section: Introductionmentioning

confidence: 99%

Growth inhibition of Staphylococcus aureus by chicken egg yolk antibodies

Guimarães¹,

Amaral²,

Rangel³

et al. 2009

Arch. Immunol. Ther. Exp.

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Introduction: The aim was to evaluate the ability of egg yolk antibody (IgY) in blocking Staphylococcus aureus growth in vitro. Materials and Methods: Specific IgY was produced by immunizing hens with formalin-killed S. aureus (ATCC 33593). Specific IgY against S. aureus was obtained from the yolks of their eggs with a carrageenan solution. IgY was identified by SDS-PAGE and Western blot and its activity against S. aureus was tested by ELISA. A growth inhibition assay and protein concentration determination were also conducted. Results: ELISA indicated that the IgY was specific to the antigen; this activity was confirmed by Western blotting. The growth of S. aureus was inhibited by the specific IgY at concentrations of 1-5 µg/ml The bacteriostatic function of IgY appeared to result possibly from the interaction of IgY with surface components of S. aureus. In vitro experiments showed that the immunoglobulin from egg yolk interfered with the culture growth of the S. aureus. Conclusion: These findings indicate that eggs from hens immunized with appropriate antigens are a potentially useful source of passive immunity.

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“…The initial estimate for the parameter value for τ is 0n01 day −" . This is based on a mean time to detection of 60 days, and an estimated cure rate after treatment of 60 % [13]. This would represent a realistic but aggressive treatment policy.…”

Section: Controlmentioning

confidence: 99%

A multispecies model for the transmission and control of mastitis in dairy cows

White

Schukken

Lam³

et al. 2001

Epidemiol. Infect.

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SUMMARYMastitis in dairy cows is a significant economic and animal welfare issue in the dairy industry. The bacterial pathogens responsible for infection of the mammary gland may be split into two main categories : major and minor pathogens. Infection with major pathogens generally results in clinical illness or strong inflammatory responses and reduced milk yields, whereas minor pathogen infection is usually subclinical. Previous investigations have considered the transmission of these pathogens independently. Experimental evidence has shown crossprotection between species of pathogens. In this study a mathematical model for the coupled transmission of major and minor pathogens along with their interaction via the host was developed in order to consider various methods for controlling the incidence of major pathogen infection. A stability analysis of the model equilibria provides explanations for observed phenomena and previous decoupled modelling results. This multispecies model structure has provided a basis for quantifying the extent of cross-protection between species and assessing possible control strategies against the disease.

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Factors Associated with Bacteriological Cure During Lactation After Therapy for Subclinical Mastitis Caused by Staphylococcus aureus

Cited by 109 publications

References 8 publications

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Growth inhibition of Staphylococcus aureus by chicken egg yolk antibodies

A multispecies model for the transmission and control of mastitis in dairy cows

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