Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation

Costa, Ana Brito; Pereira‐da‐Silva, Luís; Papoila, Ana Luísa; Alves, Marta; Mateus, Élia; Nolasco, Fernando; Barroso, Eduardo

doi:10.1097/tp.0000000000001202

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…When comparing mREE with pREE, there were differences when the formulas that require body weight were used to calculate pREE, and this may have affected the results. Some authors used the dry weight of the participants, 6,28,[47][48][49][50][51] whereas others excluded patients with clinically detectable fluid retention. 36,39,40 However, these corrections were not performed (or mentioned) in a majority of the studies.…”

Section: Ree Of Patients With Esld Vs Ree Of Healthy Controlsmentioning

confidence: 99%

“…Several authors have performed longitudinal follow‐up assessments of mREE in LTx patients , 8,9,24–26,50,53 for ≤50 months postsurgery (Table 3).…”

Section: Changes In Ree After Ltxmentioning

confidence: 99%

“…Studies with shorter follow‐up periods post‐LTx also revealed no changes in the mREE after surgery 50,53 . A survey of 25 liver recipients reported the mREE of patients, measured ≤72 hours post‐LTx (baseline) and at 5, 10, and 15 days postsurgery.…”

Section: Changes In Ree After Ltxmentioning

confidence: 99%

“…Studies with shorter follow-up periods post-LTx also revealed no changes in the mREE after surgery. 50,53 A survey of 25 liver recipients reported the mREE of patients, measured ≤72 hours post-LTx (baseline) and at 5, 10, and 15 days postsurgery. The mean baseline mREE was 1832.0 ± 952.0 kcal/d, decreasing to 1565.0 ± 383.0 kcal/d on the 5th day and 1578.0 ± 418.0 kcal/d on the 15th day, with no significant differences.…”

Section: Longitudinal Assessment Of Ree In Patients Who Underwent Ltxmentioning

confidence: 99%

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Energy Expenditure and Liver Transplantation: What We Know and Where We Are

Santos

Correia

Anastácio

2020

J Parenter Enteral Nutr

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Patients with end‐stage liver disease (ESLD) and undergoing liver transplantation (LTx) commonly present with malnutrition attributed to various etiologies. One of the causes is potential hypermetabolism resulting from increased resting energy expenditure (REE). After the surgery, it is hypothesized that these patients show a reduction in REE, which may contribute to the weight gain observed in this population. However, there have been controversial results regarding the metabolic status of ESLD patients and liver recipients, which has led us to critically review the pertinent literature. We enrolled studies with the following goals: assessment of REE of these patients either before or after surgery by using indirect calorimetry (measured REE [mREE]) and comparison of these mREE values with those of healthy controls or with REE values obtained using predictive equations (predicted REE [pREE]). For most patients, mREE and pREE values were comparable. However, ≥5.3% of patients exhibited hypermetabolism when the mREE was compared with the pREE using the Harris‐Benedict formula. Three follow‐up studies that were conducted postsurgery showed a progressive reduction in the mREE for ≤1 year. However, conflicting data have been published, and cross‐sectional studies have not reported hypometabolic patients. In conclusion, there is no consensus regarding the metabolic status of pre‐LTx and post‐LTx patients, which may be due to differences in the methods used for comparison. Therefore, we highlight this aspect of LTx patient management, which impacts the quality of nutrition therapy required by these patients.

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Section: Ree Of Patients With Esld Vs Ree Of Healthy Controlsmentioning

confidence: 99%

“…Several authors have performed longitudinal follow‐up assessments of mREE in LTx patients , 8,9,24–26,50,53 for ≤50 months postsurgery (Table 3).…”

Section: Changes In Ree After Ltxmentioning

confidence: 99%

Section: Changes In Ree After Ltxmentioning

confidence: 99%

Section: Longitudinal Assessment Of Ree In Patients Who Underwent Ltxmentioning

confidence: 99%

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Energy Expenditure and Liver Transplantation: What We Know and Where We Are

Santos

Correia

Anastácio

2020

J Parenter Enteral Nutr

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“…We are glad that these esteemed investigators who contributed so much to understanding nutrition [11,12,13,14,15] and body proportionality [11,16,17] agree that our final recommendation may be correct. We also agree that more research is needed.…”

mentioning

confidence: 99%

Reply to the Letter to the Editor “Accurate Direct Measures Are Required to Validate Derived Measures”

Clark

Ie²,

Ferguson³

et al. 2018

Neonatology

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Body composition assessment after pediatric liver transplant

Perteet-Jackson

Earthman

Price

et al. 2021

J Parenter Enteral Nutr

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Background Pediatric liver transplantation generally restores metabolic function; yet after transplantation, some children remain malnourished, have increased adiposity, and develop obesity. Measurement of body composition in the assessment of nutrition status could reduce adverse consequences in children. Methods Anthropometric measurements, multiple‐frequency bioelectrical impedance analysis, air displacement plethysmography, and ultrasound measurements were conducted on children recruited from the liver transplant program at the University of Minnesota Masonic Children's Hospital. A cross‐sectional study was conducted to describe the quality of weight gain in post–liver transplant children between the ages of 2 and 17 years using multiple assessment tools (air displacement plethysmography, multiple‐frequency bioelectrical impedance analysis, and ultrasound) and to determine whether multiple‐frequency bioelectrical impedance analysis and ultrasound accurately describe body composition and quality of weight gain. Results Mean percent body fat by air displacement plethysmography and multiple‐frequency bioelectrical impedance analysis was 18.4% (±3.3) and 19.0% (±3.9), respectively (P > .99). There were insufficient data to examine the relationship between summed muscle and adipose thickness measures by ultrasound and percent body fat determined by air displacement plethysmography or multiple‐frequency bioelectrical impedance analysis. Conclusion Percent body fat, fat mass, and fat‐free mass measures determined by air displacement plethysmography and multiple‐frequency bioelectrical impedance analysis were not statistically different, which suggests the stand‐on device used in this study could be a useful body composition assessment tool for the pediatric population.

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Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation

Abstract: The cyclosporine-based regimen was independently associated with decreased adiposity and increased skeletal muscle compared with the tacrolimus-based regimen. Future randomized controlled trials are needed to confirm these findings.

Cited by 12 publications

References 40 publications

Energy Expenditure and Liver Transplantation: What We Know and Where We Are

Energy Expenditure and Liver Transplantation: What We Know and Where We Are

Reply to the Letter to the Editor “Accurate Direct Measures Are Required to Validate Derived Measures”

Body composition assessment after pediatric liver transplant

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