Factors associated with chronic renal failure in HIV-infected ambulatory patients

Krawczyk, Christopher; Holmberg, Scott D.; Moorman, Anne C.; Gardner, Lytt I.; McGwin, Gerald

doi:10.1097/00002030-200411050-00009

Cited by 55 publications

(52 citation statements)

References 31 publications

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“…Only 21 (6%) of the 349 patients with CKD had both risk factors. The association of CD4 cell count and CKD or GFR decline has been found in several studies (23,26,32,33). Interestingly, we found an association between the time spent with a CD4 count of Ͼ200 cells/mm 3 during the last 2 years and a lower risk of CKD.…”

Section: Discussionsupporting

confidence: 77%

Risk Factors of Chronic Kidney Disease in HIV-infected Patients

Flandre¹,

Puglièse²,

Cuzin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The main aim of this study was determining the risk factors of chronic kidney disease (CKD) in HIV-1-infected patients.Design, setting, participants, & measurements Patients were followed from seven large HIV reference centers in France that maintain prospective databases on HIV-1-infected patients. The main outcome was the time to CKD defined as two consecutive measures of estimated GFR Յ60 ml/min per 1.73 m 2 over Ն3 months. A Cox's model with delayed entry was used to search predictive factors of time to CKD.Results From 1993 to 2006, 349 out of 7378 patients were found to have CKD. Of these, 166 had hypertension, 33 had diabetes, and 26 were antiretroviral therapy-naïve. Occurrence of acute kidney injury (hazard ratio [HR] ϭ 2.40) and hypertension (HR ϭ 2.39) were strongly associated with an increased risk of CKD. Patients with a durable level of CD4 count Ͼ200 cells/mm 3 had a lower risk of CKD (HR ϭ 0.63). Recent exposure to indinavir (HR ϭ 2.03), totenofovir (HR ϭ 1.55), and abacavir (HR ϭ 1.37) were associated with an increased risk of CKD. Past exposure to tenofovir was also associated with an increased risk of CKD (HR ϭ 2.23), and a trend toward significance was observed for past exposure to indinavir (HR ϭ 1.28).Conclusions CKD was not rare in HIV-infected patients and occurs preferentially in HIV-infected patients exposed to certain ARVs, specifically abacavir, indinavir and tenofovir. This requires closer monitoring of renal function in patients exposed to one of these drugs.

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Section: Discussionsupporting

confidence: 77%

Risk Factors of Chronic Kidney Disease in HIV-infected Patients

Flandre¹,

Puglièse²,

Cuzin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Several studies had demonstrated that diabetes plays an important role in kidney disease in the HIV infected patients [3,10,20]. Krawczyk et al in the United States (p=0.259) and Flandre et al in France (p=0.30) did not find an association between diabetes and chronic kidney failure among HIV infected patients [4,18].…”

Section: Prevalence Of Chronic Kidney Failure In People With Hivmentioning

confidence: 97%

“…had found in France, in 2011, in a study of risk factors for chronic kidney disease in patients infected with HIV-1 that hypertension was associated with chronic kidney failure in these patients (OR=2 39, p<0.01) [4]. Krawczyk et al had found in the United States that taking anti-hypertensive treatment is a factor associated with chronic kidney failure (p=0.004) [18]. It's important to note also that hypertension is one of the criteria used by the Infectious Diseases Society of America (IDSA) to describe HIV patients with a high risk of developing kidney disease [19].…”

Section: Prevalence Of Chronic Kidney Failure In People With Hivmentioning

confidence: 99%

Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Dm¹,

Vigan²,

Azon-Kouanou³

et al. 2015

J Nephrol Ther

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“…Highly active anti-retroviral therapy (HAART) treatment has not eliminated HIV-specific renal disease, the HIV-associated nephropathy (HIVAN), which is responsible for 40% to 60% of the histological renal disease (191), or the need for transplantation in HIV-infected patients (192). Apart from the specific role of the virus, people infected with HIV have a large number of risk factors for non-specific CRF, including age, hypertension, non-insulin-dependent diabetes and exposure to multiple long-term drug treatments (193).…”

Section: Cysc and Acquired Immunodeficiency Syndrome (Aids)mentioning

confidence: 99%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

164

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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Factors associated with chronic renal failure in HIV-infected ambulatory patients

Abstract: Our findings suggest that advanced HIV-disease, as indicated by low CD4+ cell count, is associated with subsequently developing chronic renal disease and treatment with HAART may reduce the risk of developing chronic renal disease.

Cited by 55 publications

References 31 publications

Risk Factors of Chronic Kidney Disease in HIV-infected Patients

Risk Factors of Chronic Kidney Disease in HIV-infected Patients

Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Cystatin C: current position and future prospects

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