Factors associated with circulating concentrations of irisin in the general population cohort of the ABCD study

Abstract

Our study confirms, in a cohort of a general population, that irisin concentrations gradually increase with the usual level of habitual physical activity.

The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study

“…A population-based cohort included 967 non-diabetic people living in Germany [32], this study investigated the association between irisin and lipid levels, finding a significant association with favorable lipid profile; in particular, an inverse association of irisin with total cholesterol concentration. Buscemi S, et al also found a positive association between HDL-cholesterol concentrations and irisin concentration [33]. However, we found a positive association between irisin and triglycerides, no association with total cholesterol or HDL-C.…”

“…So the conclusion should only be generalized to overweight rather than different grade of obesity. Moreover, there has been controversies regarding available irisin ELISA kits, including antibody specificity of antibody, its cross-reactivity with FNDC5 and the wide range of irisin levels between different studies [33] [35]. In addition, different ethnicity and lifestyle may have different results; generalization beyond Asian populations should be interpreted with caution.…”

Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population

“…In order to promote the participation of people of a younger age with no known cardiovascular, liver, metabolic or nutritional diseases, an echographic check of the thyroid was also proposed to the customers of the mall. The demographic characteristics of the ABCD cohort were similar to, even non‐overlapping with, those of the general population of the same range of age (18‐90 years) living in Palermo in 2011, as presented elsewhere and in Table . The original cohort was re‐contacted (telephone, e‐mail, letter) in 2015, and those who agreed to participate in the study were asked to come to the Metabolism and Clinical Nutrition Laboratory of the Department of Internal and Specialized Medicine at the University of Palermo, and were re‐examined from March 21th to July 31th.…”

Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

“…The relationship between irisin level and chronic exercise training or habitual physical activity is controversial [31]: both increasing [1,32] and decreasing [4,33] circulating irisin concentrations have been observed. In agreement with the results of the KarMeN study, that correlated irisin concentrations with both subjective and objective measures of physical activity in healthy, normal weight subjects [34], we found no association between irisin and habitual physical activity in our patients examined under resting condition.…”