Factors Associated with Diagnostic Yield of Endobronchial Ultrasonography with a Guide Sheath for Peripheral Lung Cancer

Uchimura, Keigo; Yamasaki, Kei; Ishimoto, Hiroshi; Kakinouchi, Sho; Kimura, Koki; Kanaya, Tomoko; Matsunaga, Takafumi; Kawaguchi, Takako; Fukuda, Yasuko; Sakagami, Kazuki; Hata, Ryosuke; Ideguchi, Shuhei; Takaki, Tsutomu; Shiraishi, T; Akata, Kentaro; Hanaka, Minako; Nishida, Chinatsu; Kido, Takashi; Yatera, Kazuhiro; Mukae, Hiroshi

doi:10.7888/juoeh.38.17

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…Our application of the QUADAS‐2 tool showed that these studies therefore had an undetermined risk of bias in the flow and timing component. Table S1 (Supplementary Information) lists all included studies and their performance based on QUADAS‐2 tool …”

Section: Resultsmentioning

confidence: 99%

“…Figure shows a Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) flow diagram summarizing the above‐mentioned data. Of the 57 studies included in the meta‐analysis, 2 were in Chinese and 1 was in Japanese . Rest of the studies were in English.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 57 studies included in the meta-analysis, 2 were in Chinese and 1 was in Japanese. [46][47][48] Rest of the studies were in English.…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

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Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis

et al. 2017

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Tissue diagnosis of peripheral pulmonary lesions (PPLs) can be challenging. In the past, flexible bronchoscopy was commonly performed for this purpose but its diagnostic yield is suboptimal. This has led to the development of new bronchoscopic modalities such as radial endobronchial ultrasound (R-EBUS), electromagnetic navigation bronchoscopy (ENB) and virtual bronchoscopy (VB). We performed this meta-analysis using data from previously published R-EBUS studies, to determine its diagnostic yield and other performance characteristics. Ovid MEDLINE and PubMed databases were searched for R-EBUS studies in September 2016. Diagnostic yield was calculated by dividing the number of successful diagnoses by the total number of lesions. Meta-analysis was performed using MedCalc (Version 16.8). Inverse variance weighting was used to aggregate diagnostic yield proportions across studies. Publication bias was assessed using funnel plot and Duval and Tweedie's test. 57 studies with a total of 7872 lesions were included in the meta-analysis. These were published between October 2002 and August 2016. Overall weighted diagnostic yield for R-EBUS was 70.6% (95% CI: 68-73.1%). The diagnostic yield was significantly higher for lesions >2 cm in size, malignant in nature and those associated with a bronchus sign on computerized tomography (CT) scan. Diagnostic yield was also higher when R-EBUS probe was within the lesion as opposed to being adjacent to it. Overall complication rate was 2.8%. This is the largest meta-analysis performed to date, assessing the performance of R-EBUS for diagnosing PPLs. R-EBUS has a high diagnostic yield (70.6%) with a very low complication rate.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis

et al. 2017

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“…Furthermore, the diagnostic yield of EBUS-GS can improve with an increase in the number of procedures performed, particularly among beginners (7). In summary, training is considered one of the most important factors contributing to an improved diagnostic yield of EBUS-GS for PPLs (8). However, the most suitable model for providing hands-on training in EBUS-GS remains to be elucidated.…”

Section: Original Articlementioning

confidence: 99%

A novel biosimulator based on ex vivo porcine lungs for training in peripheral tissue sampling using endobronchial ultrasonography with a guide sheath

Ishiwata¹,

Nakajima²,

Terada³

2019

J. Thorac. Dis.

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Background: Although radial probe endobronchial ultrasonography (EBUS) with a guide sheath (GS; EBUS-GS) is widely used for sampling peripheral pulmonary lesions (PPLs), a standard training model for EBUS-GS remains to be developed. The purpose of this study was to evaluate the feasibility of a novel pulmonary biosimulator for hands-on training in peripheral tissue sampling using EBUS-GS Methods: We established a novel biosimulator for EBUS-GS using porcine lungs. The simulator was equipped with multiple pseudo PPLs that were created using blue agar solution injected through GS inserted in a bronchoscope. A total of 12 voluntary trainees participated in a hands-on training course using the biosimulator. The size of samples acquired using biopsy forceps were compared between initial and posttraining biopsies, and trainee satisfaction with the biosimulator and training program were evaluated using a questionnaire. Results: Under the guidance of a trainer, all trainees successfully detected pseudo PPLs using radial probe EBUS before the initial biopsy, and 11 trainees acquired samples from the target lesions during the initial biopsy. Post-training biopsy samples were larger than the initial samples for eight trainees. The results of the questionnaire revealed that all trainees were satisfied with the biosimulator. Moreover, eight trainees who had previously participated in another hands-on EBUS-GS training program involving a synthetic phantom model showed greater satisfaction for the biosimulator. Conclusions: A hands-on training program using the novel biosimulator assessed in this study could aid clinicians in improving their skills for EBUS-GS and acquiring larger peripheral tissue samples using biopsy forceps inserted through GS.

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“…In addition, a Japanese study has shown that bronchoscopy training is an important factor for improving the diagnostic yield of EBUS-GS in PLC. [ 40 ]…”

Section: Improvement Of the Diagnostic Yield Of Endobronchial Ultrasomentioning

confidence: 99%

Endobronchial ultrasonography using a guide sheath technique for diagnosis of peripheral pulmonary lesions

Zhang

Wang

2017

Endosc Ultrasound

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Endobronchial ultrasonography using a guide sheath (EBUS-GS) is a novel method used for collecting peripheral pulmonary lesion (PPL) samples. EBUS-GS is performed by introducing a guide sheath-covered miniprobe into the target bronchus and then withdrawing the miniprobe after lesion detection, leaving the guide sheath in situ as a working channel for obtaining lesion samples. EBUS-GS can improve PPL diagnosis rates and be used for obtaining specimens for molecular analysis. In this review, we discuss the clinical applications of EBUS-GS, the factors that affect its diagnostic sensitivity, and potential complications. We also compare EBUS-GS with other available diagnostic techniques and discuss the strengths and limitations of this method.

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Factors Associated with Diagnostic Yield of Endobronchial Ultrasonography with a Guide Sheath for Peripheral Lung Cancer

Cited by 6 publications

References 12 publications

Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis

Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis

A novel biosimulator based on ex vivo porcine lungs for training in peripheral tissue sampling using endobronchial ultrasonography with a guide sheath

Endobronchial ultrasonography using a guide sheath technique for diagnosis of peripheral pulmonary lesions

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