Factors, associated with effective control of arterial hypertension in the general working-age population

Abstract

Objective. To analyze determinants and their contribution to efficiency of arterial hypertension (AH) control in the hypertensive population.Design and methods. In the cross-sectional study a total of 334 men and 436 women derived from a representative sample of the general population aged 25–64 years, meeting criteria for AH, were examined. All subjects signed voluntary informed consent to participate in the study. A standard questionnaire based on adapted international methods was used. The associative analysis included sets of socioeconomic, behavioral, psychosocial, medical and biological variables. We used univariable (χ2, Fisher exact test, Student’s t-test, Mann–Whitney test) and multivariable statistics (logistic regression). Effective AH control was considered in case of blood pressure (BP) < 140/90 mm Hg. Probabilities of error < 5% were considered statistically significant.Results. Irrespective of gender, use of hypotensive drugs was the most influential factor in ensuring effective control of AH in the population. A major barrier to reaching target BP levels in women was the number of current metabolic risk factors (RF). Age (more significant in men), general obesity (both sexes), history of kidney disease (men), elevated glucose and triglycerides (women) were also associated with ineffective AH control. Angiotensine receptor blockers, angiotensin converting enzyme inhibitors (ACEI), sympatholytics/ spasmolythics in men and ACEI, beta-blockers and diuretics (at moderate or higher affluence only) in women were associated with a higher probability of reaching BP targets. Knowledge of cholesterol level (both sexes), cardiovascular disease, use of statins, reduced quality of life (difficulty with daily activities), sedentary working activity and affluence in men were also associated with effective control of BP.Conclusions. The data obtained demonstrate that with an increase in the coverage of the hypertensive population with antihypertensive treatment, an increase in the proportion of people reaching the target BP levels may be significant, but still the most important issue is the treatment efficiency. The need to correct behavioral factors that lead to the development of metabolic disorders, especially obesity, but also other RF, remains the most challenging issue in this regard. The findings convince us that it is advisable to take measures to increase awareness of the main cardiovascular disease RF, to involve patients more in controlling their RF, to prescribe statins more frequently, to create conditions for taking antihypertensive drugs in the so-called “mobile” types of working activity, to keep developing infrastructure for mass participation of population in sport activities, and to improve economic conditions.

Hypertension as a death risk factor in men and women aged 20-59 years: a 34-year cohort prospective study

“…Таким образом, представленные нами результаты демонстрирует высокую значимость АГ как ФР, оказывающего влияние на риск смерти от ССЗ и от всех причин в течение длительного периода, что соответствует результатам исследований, выполненных в России и в других странах мира [2,3,6]. Согласно крупному систематическому анализу изучения глобального бремени болезней в 195 странах с 1990 по 2017гг АГ признана ведущим ФР, на долю которого приходилось наибольшее количество потерянных лет жизни, а также лет жизни, скорректированных по нетрудоспособности [2].…”

“…В настоящее время повышенное артериальное давление (АД) отмечается у 1,28 млрд жителей планеты 1 . В мире ежегодно по причинам, связанным с АГ, уходят из жизни до 10,4 млн людей [1,3]. Увеличение средней продолжительности жизни и глобальное старение населения, наблюдаемые в последние десятилетия в большинстве экономическиразвитых стран, способствуют росту удельного веса АГ в структуре сердечно-сосудистой заболеваемости и увеличению значимости этого предиктора в формировании риска смерти [4].…”