Factors Associated with Geographic Patterns of Poor Sustained Viral Suppression in Miami-Dade County Florida, 2017

Dawit, Rahel; Trepka, Mary Jo; Duncan, Dustin T.; Gbadamosi, Semiu O; Tan, Li; Pires, Stephen F.; Ladner, Robert A.; Sheehan, Diana M.

doi:10.1007/s40615-021-01227-w

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Many PWH experience prominent structural vulnerabilities such as housing instability and food insecurity that should receive greater attention in biobehavioral research (87,156). These structural vulnerabilities are often embedded within distinct residential environments, and a burgeoning literature has focused on demonstrating the associations of neighborhood-level factors with health outcomes such as viral suppression (157)(158)(159). Advancing our understanding of multilevel determinants of microbiome-gut-brain axis alterations will guide the development of more comprehensive intervention approaches to address prevalent neuropsychiatric comorbidities and optimize health outcomes among PWH.…”

Section: Through the Looking-glass: Recommendations For Pni And Micro...mentioning

confidence: 99%

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

et al. 2022

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Objective: Depression, substance use disorders, and other neuropsychiatric comorbidities are common in people with HIV (PWH), but the underlying mechanisms are not sufficiently understood. HIV-induced damage to the gastrointestinal tract potentiates residual immune dysregulation in PWH receiving effective antiretroviral therapy. However, few studies among PWH have examined the relevance of microbiomegut-brain axis: bidirectional crosstalk between the gastrointestinal tract, immune system, and central nervous system. Methods: A narrative review was conducted to integrate findings from 159 articles relevant to psychoneuroimmunology (PNI) and microbiome-gut-brain axis research in PWH. Results: Early PNI studies demonstrated that neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis and autonomic nervous system could partially account for the associations of psychological factors with clinical HIV progression. This review highlights the need for PNI studies examining the mechanistic relevance of the gut microbiota for residual immune dysregulation, tryptophan catabolism, and oxytocin release as key biological determinants of neuropsychiatric comorbidities in PWH (i.e., body-to-mind pathways). It also underscores the continued relevance of neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and oxytocin release in modifying microbiome-gut-brain axis functioning (i.e., mind-to-body pathways). Conclusions: Advancing our understanding of PNI and microbiome-gut-brain axis pathways relevant to depression, substance use disorders, and other neuropsychiatric comorbidities in PWH can guide the development of novel biobehavioral interventions to optimize health outcomes. Recommendations are provided for biobehavioral and neurobehavioral research investigating bidirectional PNI and microbiomegut-brain axis pathways among PWH in the modern antiretroviral therapy era.

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Section: Through the Looking-glass: Recommendations For Pni And Micro...mentioning

confidence: 99%

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

et al. 2022

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Navigating Challenges in Community-based Research Aimed at Ending the HIV Epidemic Among Black Women

Joe,

Brown,

Dunn

2024

Journal of Participatory Research Methods

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Our interdisciplinary team initiated a community-based participatory research project aimed at dismantling the gendered racism faced by Black women in healthcare settings that makes them vulnerable to HIV and other health conditions. During the data collection phase of the project, we encountered multiple challenges with the recruitment and enrollment of Black women in the study as well as with an influx of fraudulent responses that slowed down the research process. In this article, we discuss our research methodology followed by details of the challenges we faced and the processes we used to navigate those challenges.

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Factors Associated with Geographic Patterns of Poor Sustained Viral Suppression in Miami-Dade County Florida, 2017

Cited by 2 publications

References 38 publications

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

Navigating Challenges in Community-based Research Aimed at Ending the HIV Epidemic Among Black Women

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