Factors Associated with Imaging in Patients with Early Breast Cancer After Initial Treatment

Enright, Katherine; Desai, Tejas; Sutradhar, Rinku; Gonzalez, Alejandro; Powis, Melanie Lynn; Taback, Nathan; Booth, Christopher M.; Trudeau, Maureen; Krzyzanowska, M. K.

doi:10.3747/co.25.3838

Cited by 12 publications

(18 citation statements)

References 26 publications

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“…We found that patients having had radiotherapy or chemotherapy were more likely to FU examinations after surgery. This result was consistent with the reports by Enright and Neuman that breast cancer patients who have undergone more intensive treatment have better adherence and more frequent FU [20,31]. Generally speaking, patients with more severe disease should be Abbreviations: ER Estrogen receptor status, PR Progesterone receptor status, HER 2 Human epidermal growth factor receptor 2 *Adjusted ORs in the final model from step-wise logistic regression analysis by including all the variables in the Table with P < 0.10 from univariate logistic regression and eliminate each at a time justified by likelihood ratio test [13] treated with more intensive treatment.…”

Section: Discussionsupporting

confidence: 93%

Adherence to post-surgery follow-up assessment and its association with sociodemographic and disease characteristics in patients with breast cancer in Central China

et al. 2020

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Background Follow-up after curative surgery is increasingly recognized as an important component of breast cancer care. Although current guideline regulates the follow-ups, there are no relevant studies on the adherence to it in China. This study investigated the post-surgery follow-up and explored its association with patients, tumor and treatment characteristics. Methods A total of 711 patients underwent surgical treatment in Shanxi Bethune Hospital from March 2012 to May 2018 were included in this study. Baseline sociodemographic, tumor, and treatment characteristics were obtained from the hospital electronic medical records. The post-surgery follow-up was reviewed and assessed from the patient’s follow-up examination record. Factors associated with the first three-year follow up was evaluated using logistic regression analysis. Results The annual follow-up rate after surgery decreased gradually from 67.1% at the 1st year, 60.2% at the 3rd year to 51.9% at the 4th year, and 43.5% at the 5th year. Loss of follow-up during the first 3 years after surgery was significantly associated with older age (> 65 years), lower medical insurance coverage, axillary lymph node dissection, and less intensity of systemic treatment. Conclusion A significant downtrend of annual follow-up rate for breast cancer survivors was confirmed in this study. Loss of follow-up within the first 3 years after surgery was associated with both patient’s characteristics and treatment. These results will provide evidence to help clinicians to develop tailored patient management after curative surgery.

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Section: Discussionsupporting

confidence: 93%

Adherence to post-surgery follow-up assessment and its association with sociodemographic and disease characteristics in patients with breast cancer in Central China

et al. 2020

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“…The small amount of overuse of surveillance imaging in BC, MB and ON (Fig. 3a) may be a result of too restrictive definition of an eligible test in our study (imaging only considered “surveillance” if > 330 days from last such test), as other ON studies reported multiple surveillance tests in Year 2 post-treatment [41, 42]. In NS, a different approach was utilized based on availability of screening imaging event data in the provincial screening database, which would account for the higher proportion of patients reported to have received surveillance imaging in excess of guideline recommendations.…”

Section: Discussionmentioning

confidence: 93%

“…The amount of breast cancer post-treatment care delivered by PCPs differs by province in Canada [37], and underuse and overuse of guideline-based care has been identified in other countries [38, 39] and in two provinces [40] [41, 42]. The objective of this study was to assess and compare quality of post-treatment care in Canadian provinces by determining provincial variation in the level of compliance with guideline-based breast cancer-related survivor care, general preventive care, and ongoing care for comorbidities, using administrative datasets.…”

Section: Introductionmentioning

confidence: 99%

Adherence to quality breast cancer survivorship care in four Canadian provinces: a CanIMPACT retrospective cohort study

et al. 2019

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Background In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, and may vary by province. We determined and compared the proportion of patients in each province who received adherent and non-adherent surveillance for recurrence, new cancers and late effects, recommended preventive care, and recommended physician visits for comorbidities. Methods Cohorts consisted of all adult women diagnosed with incident invasive breast cancer between 2007 and 2010/2012 in four Canadian provinces (British Columbia (BC) N = 9338; Manitoba N = 2688; Ontario N = 23,700; Nova Scotia (NS) N = 2735), identified from provincial cancer registries, alive and cancer-free at 30 months post-diagnosis. Their healthcare utilization was determined from one to 5 years post-treatment, using linked administrative databases. Adherence, underuse, and overuse of recommended services were evaluated yearly and compared using descriptive statistics. Results In all provinces and follow-up years, the majority of survivors had more than the recommended number of visits to either an oncologist or primary care physician (range 53.8% NS Year 3; 85.8% Ontario Year 4). The proportion of patients with the guideline-recommended number of oncologist visits varied by province (range 29.8% BC Year 5; 74.8% Ontario Year 5), and the proportion of patients with less than the recommended number of specified breast cancer-related visits with either an oncologist or primary care physician ranged from 32.6% (Ontario Year 2) to 84.4% (NS Year 3). Underuse of surveillance breast imaging was identified in NS and BC. The proportion of patients receiving imaging for metastatic disease (not recommended in the guidelines) in BC, Manitoba, and Ontario (not reported in NS) ranged from 20.3% (BC Year 5) to 53.3% (Ontario Year 2). Compliance with recommended physician visits for patients with several chronic conditions was high in Ontario and NS. Preventive care was less than optimal in all provinces with available data. Conclusions Quality of breast cancer survivor follow-up care varies among provinces. Results point to exploration of factors affecting differences, province-specific opportunities for care improvement, and the value of administrative datasets for health system assessment.

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“…AuT can be performed successfully in CML patients [74], but the bcr\abl translocation reappeared in a majority of patients, even those transplanted in chronic phase. It remains unclear whether relapsing CML cells always originate from residual host cells escaping from the preparative regimen or from CML cells present in the stem-cell graft, but Deisseroth et al [75] have demonstrated that malignant cells, present in the graft, contribute to disease recurrence.…”

Section: Extra-corporeal Purging Of CML Cellsmentioning

confidence: 99%

Ex vivo photodynamic purging in chronic myelogenous leukaemia and other neoplasias with rhodamine derivatives

Villeneuve

1999

Biotech and App Biochem

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Photodynamic therapy (PDT), a cancer treatment already used early in this century, has distinctive advantages over conventional chemotherapy, namely its often observed preferential accumulation in cancer cells and its low intrinsic toxicity. Aggressive therapeutic modalities using high doses of chemotherapy and/or radiation therapy are now commonplace treatments for leukaemia, lymphoma and various non‐haematologic malignancies. These intensive approaches have often been used in association with haematopoietic‐progenitor‐cell support and have induced major responses and remissions in patients with relapsed and refractory diseases, ultimately contributing to improve the disease‐free survival of patients with high risk. This has encouraged Theratechnologies, a Montreal‐based pharmaceutical company, to develop photodynamic ex vivo purging procedures, including the development of new photosensitizers and irradiation devices for the safe eradication of neoplastic cells from autologous grafts. Our first specific objective, therefore, was to design, synthesize, purify and test photoactive rhodamine derivatives. We have also selected a gas and phosphorus coating characteristic of an efficient scanning fluorescent source for extra‐corporeal PDT using rhodamine derivatives. 4,5‐Dibromorhodamine 123 (TH9402) was selected because of its photophysical properties, low toxicity and stability. TH9402 photodynamic‐cell‐therapy process conditions recognized as safe for normal human haematopoietic stem cells and progenitors demonstrated the efficacy of the purging procedure on various leukaemias (including chronic‐myelogenous‐leukaemia as well as non‐Hodgkin‐leukaemias and metastatic‐breast‐cancer cell lines.

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Factors Associated with Imaging in Patients with Early Breast Cancer After Initial Treatment

Abstract: Despite recommendations against its use, imaging is common in ebc survivors. Understanding the factors associated with aie use helps to identify areas for further research and is required to lower imaging rates and to improve survivorship care.

Cited by 12 publications

References 26 publications

Adherence to post-surgery follow-up assessment and its association with sociodemographic and disease characteristics in patients with breast cancer in Central China

Adherence to post-surgery follow-up assessment and its association with sociodemographic and disease characteristics in patients with breast cancer in Central China

Adherence to quality breast cancer survivorship care in four Canadian provinces: a CanIMPACT retrospective cohort study

Ex vivo photodynamic purging in chronic myelogenous leukaemia and other neoplasias with rhodamine derivatives

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