Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected Brazilian women

Grinsztejn, Beatriz; Veloso, Valdiléa G.; Levi, José Eduardo; Velasque, Luciane; Luz, Paula M.; Friedman, Ruth Khalili; Andrade, Angela Cristina Vasconcelos de; Moreira, Ronaldo I.; Russomano, Fábio Bastos; Pilotto, José Henrique; Bastos, Francisco I.; Palefsky, Joel M.

doi:10.1016/j.ijid.2008.03.031

Cited by 58 publications

(77 citation statements)

References 49 publications

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“…Data from previous studies found that cofactors increased the positivity of HPV among women living with HIV such as age greater than or equal to 35 years and greater partners [49,50]. However, in our study, none of the demographic factors was associated with HPV infection.…”

Section: Discussioncontrasting

confidence: 88%

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Ouladlahsen¹,

Fayssel

Bensghir³

et al. 2018

J Infect Dev Ctries

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Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS. Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively. Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83,33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm 3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap. Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

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Section: Discussioncontrasting

confidence: 88%

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Ouladlahsen¹,

Fayssel

Bensghir³

et al. 2018

J Infect Dev Ctries

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“…Esses exames foram realizados de maneira não cega, isto é, os examinadores tinham conhecimento do resultado do exame citológico ao realizarem a colposcopia, sendo ele verdadeiro para o exame histopatológico. Maiores detalhes sobre outros procedimentos e análises epidemiológicas relacionadas à coorte podem ser encontradas na literatura 25,26 .…”

Section: Métodosunclassified

Desempenho do exame citológico e da captura híbrida II no rastreamento de lesões intraepiteliais escamosas de alto grau em mulheres HIV+

et al. 2011

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HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), IntroduçãoO câncer do colo do útero é a segunda neoplasia mais frequente entre mulheres 1 . O papiloma vírus humano (HPV) do tipo oncogênico é uma causa necessária para o desenvolvimento do câncer do colo do útero 2,3,4 . As lesões intraepiteliais escamosas de alto grau (high grade squamous intraepithelial lesions -HSIL) são atipias do epitélio cervical precursoras do câncer do colo do útero que podem ser rastreadas de diversas formas 5 . Na maioria dos países desenvolvidos e em desenvolvimento, a prevenção é feita pelo rastreamento das HSIL durante exame citológi-co, ou exame de Papanicolaou, seguido da colposcopia e tratamento das lesões confirmadas. Tal estratégia determinou, nas últimas décadas, uma redução da incidência e mortalidade do câncer do colo do útero, especialmente em paí-ses desenvolvidos onde a taxa de cobertura desse exame de rastreio é alta 6 . Atualmente, estão disponíveis outros métodos para o rastreamento das HSIL como, por exemplo, exame citológico em meio líquido, exames para detecção de DNA de HPV oncogênico, inspeção visual com ácido acético, dentre outras. É possível que diferentes técnicas de rastreamento sejam mais adequadas em algum contexto específico em razão de capacidade diagnóstica e custos diferenciados.As recomendações com relação ao rastreamento das HSIL em mulheres infectadas pelo vírus da imunodeficiência humana (HIV+) estão ARTIGO ARTICLE

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“…20,21 As such, HIV-infected women in Brazil may be at heightened risk for the development and progression of HPV-induced disease. Among HIV-infected women, studies from Brazil have evidenced a high prevalence of HPV infection 22 and increased risk to progression from HSIL to invasive cervical cancer. 23 Thus, it is necessary to provide consistent cervical cancer screening and to link screening and care in such a manner that it ensures effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Cervical cytological abnormalities and factors associated with high-grade squamous intraepithelial lesions among HIV-infected women from Rio de Janeiro, Brazil

et al. 2012

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Although cervical cancer remains a major public health problem in Brazil, knowledge of cervical cytological abnormalities among HIV-infected women remains scarce. At baseline evaluation of a cohort followed in Rio de Janeiro, Brazil, 703 HIV-infected women underwent cytology-based cervical cancer screening and human papillomavirus (HPV) DNA testing. Poisson regression analysis was used to evaluate the association of factors with the presence of high-grade squamous intraepithelial lesions (HSIL). Cervical cytology was abnormal in 24.3% of the women; 4.1% had HSIL. Beyond HPV infection, factors independently associated with the presence of HSIL was age (≥25 and ≤40 years, prevalence ratio [PR] 2.60, 95% confidence interval [CI] 1.11-6.10), and more than three pregnancies was protective (PR 0.33, 95% CI 0.11-0.94). High coverage of cervical cancer screening is warranted to prevent morbidity and mortality from cervical cancer in this population.

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Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected Brazilian women

Abstract: The estimated prevalence of high-risk HPV-infection among HIV-infected women from Rio de Janeiro, Brazil, was high. Close monitoring of HPV-related effects is warranted in all HIV-infected women, in particular those of younger age and advanced immunosuppression.

Cited by 58 publications

References 49 publications

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

Desempenho do exame citológico e da captura híbrida II no rastreamento de lesões intraepiteliais escamosas de alto grau em mulheres HIV+

Cervical cytological abnormalities and factors associated with high-grade squamous intraepithelial lesions among HIV-infected women from Rio de Janeiro, Brazil

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