Factors Associated with Interest in Gene‐Panel Testing and Risk Communication Preferences in Women from <i>BRCA1/2</i> Negative Families

Flores, Kristina G.; Steffen, Laurie E.; McLouth, Christopher J.; Vicuña, Belinda; Gammon, Amanda; Kohlmann, Wendy; Vigil, L.; Dayao, Zoneddy; Royce, Melanie; Kinney, Anita Y.

doi:10.1007/s10897-016-0001-7

Cited by 16 publications

(11 citation statements)

References 54 publications

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“…High cancerspecific worry and recent mammography were independently associated with multigene panel testing interest. Unlike prior studies of interest in multigene panel testing (Elrick et al 2016;Flores et al 2016), our study included a relatively large proportion of Hispanics. Hispanic women did differ from non-Hispanic women in their preferences for web-based cancer risk communication.…”

Section: Discussionmentioning

confidence: 99%

Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families

et al. 2017

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Until recently, genetic testing for hereditary breast cancer has primarily focused on pathogenic variants in the BRCA1 and BRCA2 (BRCA) genes. However, advances in DNA sequencing technologies have made simultaneous testing for multiple genes possible. We examined correlates of interest in multigene panel testing and risk communication preferences in an ethnically diverse sample of women who tested negative for BRCA mutations previously but remain at high risk based on their family history (referred to as "BRCA-uninformative") and their at-risk female family members. Two-hundred and thirteen women with a previous breast cancer diagnosis and a BRCA-uninformative test result and their first-degree relatives completed a survey on interest in multigene panel testing, communication preferences, and sociodemographic, psychological, and clinical factors. Stepwise logistic regression was used to identify factors associated with testing interest. Chi-square analyses were used to test differences in risk communication preferences. Interest in multigene panel testing was high (84%) and did not considerably differ by cancer status or ethnicity. In multivariable analysis, factors significantly associated with interest in genetic testing were having had a mammogram in the past 2 years (odds ratio (OR) = 4.04, 95% confidence interval (CI) 1.80-9.02) and high cancer worry (OR = 3.77, 95% CI 1.34-10.60). Overall, the most commonly preferred genetic communication modes were genetic counselors, oncologists, and print materials. However, non-Hispanic women were more likely than Hispanic women to prefer web-based risk communication (p < 0.001). Hispanic and non-Hispanic women from BRCA-uninformative families have a high level of interest in gene panel testing. Cancer-related emotions and communication preferences should be considered in developing targeted genetic risk communication strategies.

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Section: Discussionmentioning

confidence: 99%

Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families

et al. 2017

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“…Bakos et al (2008) found that patients with a negative BRCA result still worried about carrying a harmful mutation that had not been discovered and felt that their risk of getting cancer was higher than the general population. Flores et al (2016) conducted a study to examine the factors that impact interest in genetic testing for modest and moderate breast cancer risk genes in female first-degree relatives of breast cancer patients who tested negative for BRCA1 and BRCA2 mutations. Interest in testing was reportedly high at 70% and was higher if the results could guide risk-reducing behaviors.…”

Section: ; Moranmentioning

confidence: 99%

Factors Influencing Clinical Follow‐Up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Uninformative BRCA1 and BRCA2 Testing

Chadwell

Knapke³

et al. 2018

Journal of Genetic Counseling

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Genetic testing for inherited cancer risk has recently improved through the advent of multi-gene panels and the addition of deletion and duplication analysis of the BRCA genes. The primary aim of this study was to determine which factors influence the intent of individuals with a personal history of breast and/or ovarian cancer and negative or uncertain BRCA1 and BRCA2 testing to return to a hereditary cancer program for additional genetic risk assessment, counseling, and testing. Surveys were sent to 1197 individuals and 257 were returned. Of those participants who were planning to return to clinic, most cited having family members who could benefit from the test result as the primary motivation to return. Many participants who were not planning to return to clinic cited the cost of testing as a barrier to return. Cost of testing and concerns about insurance coverage were the most commonly cited barriers for the group of participants who were undecided about returning to clinic. Results from this study may be used to guide re-contact efforts by clinicians to increase patient uptake to return to clinic for up-to-date genetic risk assessment, counseling, and testing.

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“…11 There is also varied evidence on women's preferences for delivery of risk assessment results. Research from the United States suggests that women have mixed preferences for written (vs. face-to-face) information, and from primary care clinicians and genetic counsellors, 12,13 whereas participants in a study in Sweden found a consultation with a cancer specialist was most preferable. 8 To our knowledge, this has not been assessed in England, which has a different healthcare system.…”

Section: Introductionmentioning

confidence: 99%

Attitudes towards risk-stratified breast cancer screening among women in England: A cross-sectional survey

et al. 2019

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Objectives Risk stratification may improve the benefit/harm ratio of breast screening. Research on acceptability among potential invitees is necessary to guide implementation. We assessed women’s attitudes towards and willingness to undergo risk assessment and stratified screening. Methods Women in England aged 40–70 received summary information about the topic, and completed face-to-face computer-assisted interviews. Questions assessed willingness to undergo multifactorial breast cancer risk assessment, more frequent breast screening (if at very high risk), or less frequent or no screening (if at very low risk), and preferences for delivery of assessment results. Results Among 933 women, 85% considered breast cancer risk assessment a good idea, and 74% were willing to have it. Among 125 women unwilling to have risk assessment, reasons commonly related to ‘worry’ (14%) and ‘preferring not to know’ (14%). Among those willing to have risk assessment ( n = 689), letters/emails were generally preferred (42%) for results about very low-risk status. Face-to-face communication was most commonly preferred for results of very high-risk status (78%). General practitioners were most commonly preferred sources of assessment results (≈40%). Breast cancer specialists were often preferred for results of very high-risk status (38%). Risk-stratified breast screening was considered a good idea by 70% and 89% were willing to have more frequent screening. Fewer would accept less (51%) or no screening (37%) if at very low risk. Conclusions Women were generally in favour of multifactorial breast cancer risk assessment and risk-stratified screening. Some were unwilling to accept less or no screening if at very low risk.

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Factors Associated with Interest in Gene‐Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families

Cited by 16 publications

References 54 publications

Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families

Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families

Factors Influencing Clinical Follow‐Up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Uninformative BRCA1 and BRCA2 Testing

Attitudes towards risk-stratified breast cancer screening among women in England: A cross-sectional survey

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