Factors Associated with Masked Uncontrolled Arterial Hypertension in Patients Receiving Antihypertensive Treatment

Abstract

The aim of the study: to determine the frequency of the identify using a home blood pressure measurement (BP) masked uncontrolled arterial hypertension (MUAH), its sustainability and its associated factors at different stages algorithmization antihypertensive therapy on the basis of a fixed combination of perindopril and amlodipine in patients with uncomplicated hypertension.
 Materials and methods. In an open prospective study were included 501 patients aged from 35 to 75 years (mean age 58,0±9.5 years). Of these, 221 cases (44.1%) patients with uncomplicated essential AH with AO ≥160/100 mm Hg (in individuals not previously treated) or ≥140/90 mm Hg in the case of the previously assigned antihypertensive therapy. The research design included a period of 6 months 6 visits: 7 days, 1, 2, 3 and 6 months. Step1by1step algorithm for the treatment of patients was provided for the appointment of a fixed combination of perindopril and amlodipine, consecutive appointment, if necessary, indapamide retard, spironolactone, moxonidine or doxazosin to achieve the target office BP.
 Results. It was found that the proposed algorithm treatment not only gives the opportunity for 6 months to achieve therapeutic goals relative to the target level of office BP in 78.9% of patients, but in 56,8% decrease among them the percentage of persons with the MUAH.
 Conclusion. According to the home definition of BP at different stages of antihypertensive therapy MUAH inherent to 23.5–51.6% of patients with controlled office AO and later persists not less than one-third of patients. Algorithmization antihypertensive therapy on the basis of a fixed combination of perindopril and amlodipine allows reducing the percentage of patients with MN of hypertension among patients with target office BP at 56.8 per cent for 6 months of treatment.