Factors Associated with Paraoxonase Genotypes and Activity in a Diverse, Young, Healthy Population: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Thyagarajan, Bharat; Jacobs, David R.; Carr, J. Jeffrey; Alozie, Ogechika; Steffes, Michael W.; Kailash, Poonguzhali; Hayes, Jennifer; Gross, Myron D.

doi:10.1373/clinchem.2007.099044

Cited by 33 publications

(20 citation statements)

References 36 publications

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“…Two previous studies have investigated the relationship between PON1 and CACS. In the Coronary Artery Risk Development in Young Adults Study, there was no association between PON1 activity and CACS [35], while in the Diabetes Heart Study there were modest associations between CACS and the PON1-Q192R (P = 0.002) and PON2-S311C genotypes (P = 0.037) [36]. Further, much larger studies are required to determine any relationships between PON1 parameters and CACS.…”

Section: Discussionmentioning

confidence: 96%

Paraoxonase-1 Is Not Associated with Coronary Artery Calcification in Type 2 Diabetes: Results from the PREDICT Study

Mackness¹,

Marsillach

Elkeles

et al. 2012

Disease Markers

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Abstract. Objectives:To determine any association between serum paraoxonase-1 (PON1) activity, protein and coding region genetic polymorphisms and coronary artery calcification (CACS) and to determine factors which modulate serum PON1 in type 2 diabetes (T2DM). Methods and results: 589 patients (419 Caucasian, 120 South Asian, 50 other) from the PREDICT Study were investigated. All patients were asymptomatic for coronary disease and had established T2DM. CACS, lipids, lipoproteins, inflammatory markers, insulin resistance and PON1 activity, concentration and Q192R and L55M genotypes were measured. Independent associations were: 1) PON1 activity negatively with insulin resistance, triglycerides and PON1-55 genotype and positively with PON1-192 genotype; 2) PON1 concentration negatively with Caucasian ethnicity, duration of diabetes and statin use and positively with plasma creatinine and PON1-192 genotype. There was no association between CACS and any of the PON1 activity, concentration or genotype and this finding was not different in the various ethnic groups within the PREDICT study. Conclusion: PON1 is modulated by a number of factors, some of which are reported here for the first time, including ethnicity and insulin resistance in subjects with T2DM. No association between CACS and PON1 was found.

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Section: Discussionmentioning

confidence: 96%

Paraoxonase-1 Is Not Associated with Coronary Artery Calcification in Type 2 Diabetes: Results from the PREDICT Study

Mackness¹,

Marsillach

Elkeles

et al. 2012

Disease Markers

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“…It is possible that HDL may be dysfunctional in patients with migraine or become dysfunctional over time. PON1 was reported not to play an important role in the early pathogenesis of cardiovascular diseases in young adults in the Coronary Artery Risk Development in Young Adults study (33). When the relationship between HDL dysfunction and PON1 activity was considered, time may be an important factor in atherosclerosis development.…”

Section: Discussionmentioning

confidence: 98%

Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine

Eren¹,

Dirik²,

Neşeli̇oğlu³

et al. 2017

tnd

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Objective: Paraoxonase 1 (PON1) is associated with high-density lipoprotein (HDL) and inhibits low-density lipoprotein (LDL) oxidation. The antioxidant and antiatherogenic characteristics of HDL are attributed to this feature. The mechanisms defined in the vascular atherosclerotic process, such as inflammation, oxidative stress, and endothelial dysfunction, are also present in migraine pathophysiology. The association between hyperlipidemia and migraine has been described in various studies; however, different results have been reported. We aimed to evaluate the general lipid profiles and the relationship between PON1, arylesterase (ARE) activity, and HDL levels in patients with migraine. Materials and Methods:The study group comprised 150 patients with migraine. The control group included 71 age-and sex-matched healthy subjects. None of the subjects in either group had any vascular risk factors. PON1 and ARE activities were evaluated using a method developed by Erel. Serum lipid levels were measured using an autoanalyzer (Roche Hitachi Cobas c501).Results: Serum lipid profiles, PON1/ARE activity and HDL levels were similar to those of the control group. No statistical correlation was found between lipid parameters and PON1 or ARE levels in the patient and control groups.Conclusion: According to our results, investigating PON1 and ARE activities may be meaningless whenever migraineurs have no vascular risk factors. On the other hand, studies of longer duration will be required to evaluate the longitudinal relationship between PON1 and ARE activity in the etiopathogenesis of migraine.Keywords: Paraoxonase, arylesterase, high-density lipoprotein, migraine Amaç: Paraoksonaz 1 (PON1) yüksek yoğunluklu lipoprotein (HDL) ile ilişkilidir ve düşük yoğunluklu lipoproteinin (LDL) oksidasyonunu inhibe eder. HDL'nin antioksidan ve antiaterojenik özelliği bu duruma bağlanmaktadır. Vasküler aterosklerotik süreçte tanımlanan enflamasyon, oksidatif stres ve endotelyal disfonksiyon gibi mekanizmalar migren patofizyolojisinde yer almaktadır. Çeşitli çalışmalarda hiperlipidemi migren ilişkisi tanımlanmıştır ancak farklı sonuçlar bildirilmiştir. Biz bu çalışmada migren hastalarında genel lipid profili ve PON1, ARE aktivitesi ile HDL düzeyleri arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntem:Çalışma grubuna 150 migren hastası alındı. Kontrol grubu yaş ve cinsiyet uyumlu 71 sağlıklı bireyden oluşmaktadır. Her iki gruptaki bireylerde herhangi bir vasküler risk faktörü yoktu. PON1, arilesteraz (ARE) aktiviteleri Erel tarafından geliştirilen yöntem kullanılarak değerlendirilmiştir. Serum lipid düzeyleri otoanalizör (Roche Hitachi Cobas c501) kullanılarak ölçüldü. Abstract Öz 117Original Article / Özgün Araştırma DO I:10.4274/tnd.09216 Turk J Neurol 2017;23:117-121

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“…Moreover, PON1 levels are sensitive to the specific (functional) polymorphic variants of Leu55Met and/or Gln192Arg. Thus, polymorphic phenotypes (PON55 and PON192) of PON1 have been correlated with cardiovascular risk [12] including that induced by macrovascular pathogenesis [19], and with developing acute ischemic stroke [20,21] as well as renal disease [22]. …”

Section: Discussionmentioning

confidence: 99%

Paraoxonase (PON1) Gene Polymorphisms in Fabry Disease: Correlation with Renal Disease

Shemesh

Whybra²,

Delgado-Sanchez³

et al. 2010

Nephron Clin Pract

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Background: Fabry disease is associated with cardiomyopathy, early-onset stroke, and progressive renal failure, and other features. No markers predict multisystemic disease progression. The hypothesis of the current study is to assess a clinically relevant marker for Fabry disease using polymorphic genotyping of a marker that has been shown to be involved in interrelated cardiac, vascular, and renal abnormalities in patients not affected by Fabry disease. The paraoxonase (PON1) polymorphisms, Leu55Met and Gln192Arg, modulate intima-medial artery thickening, prognosis of cardiovascular stroke, and renal failure in other diseases. Methods: PON1 polymorphisms were ascertained. The Mainz Severity Score Index (MSSI) for Fabry disease was calculated. Local Institutional Review Board approval was received. Results: 104 patients (58 female) and 46 controls (23 female) were evaluated. There was a significant difference (p = 0.04) in PON55LL (42.3%) among patients as compared to controls (21.7%) but none in PON192 genotypes. PON55 variant (MM) was correlated with severe MSSI renal sub-scores (p < 0.001) also when age-adjusted but not with cardiac, neurological, or general sub-scores. PON55LL genotype, correlated with higher PON1 activity, had lowest α-galactosidase-A activity (n = 45). Conclusion: There was no combined effect of PON55-PON192 polymorphisms. PON55LL was more common among patients. PON55MM genotype was correlated with non-mild renal sub-scores. However, sample size needs to be enlarged.

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Factors Associated with Paraoxonase Genotypes and Activity in a Diverse, Young, Healthy Population: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Cited by 33 publications

References 36 publications

Paraoxonase-1 Is Not Associated with Coronary Artery Calcification in Type 2 Diabetes: Results from the PREDICT Study

Paraoxonase-1 Is Not Associated with Coronary Artery Calcification in Type 2 Diabetes: Results from the PREDICT Study

Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine

Paraoxonase (PON1) Gene Polymorphisms in Fabry Disease: Correlation with Renal Disease

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