Factors Associated with Postoperative Pulmonary Morbidity After Esophagectomy for Cancer

Zingg, Urs; Smithers, B. Mark; Gotley, D. C.; Smith, Garett; Aly, Ahmad; Clough, Alan R.; Esterman, Adrian; Jamieson, Glyn G.; Watson, David I.

doi:10.1245/s10434-010-1474-5

Cited by 155 publications

(121 citation statements)

References 30 publications

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“…As esophageal adenocarcinoma is associated with a strong male gender bias of up to 8:1 [16], all individuals contributing blood samples for this study were male. In addition the Barrett's esophagus and control groups were age matched to the cancer group with median age 70 ± 13, 65 ± 14 and 66 ± 10 respectively (p=0.25, ANOVA).…”

Section: Patient Recruitmentmentioning

confidence: 99%

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

Chiam

Wang

Watson

et al. 2015

Journal of Gastrointestinal Surgery

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122

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Section: Patient Recruitmentmentioning

confidence: 99%

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

Chiam

Wang

Watson

et al. 2015

Journal of Gastrointestinal Surgery

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122

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“…More recent reports from the 2000's describe mortality rates of 3-5%, again with lower mortality rates consistently reported from high volume centres [28]. A study from our centres described an in hospital mortality rate for esophagectomy in five Australian hospitals of 3.5% [29]. A lower mortality rate of 1.2% has been reported for esophagectomy in patients specifically presenting with stage T1 adenocarcinoma or HGD [30].…”

Section: Discussionmentioning

confidence: 52%

Modeling the Cost-effectiveness of Strategies for Treating Esophageal Adenocarcinoma and High-grade Dysplasia

Gordon

Hirst

Mayne

et al. 2012

Journal of Gastrointestinal Surgery

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Objective: To synthesize cost and health outcomes for current treatment pathways for esophageal adenocarcinoma and high grade dysplasia, and model comparative net clinical and economic benefits of alternative management scenarios. Methods Conclusion:These findings support measures that promote earlier diagnosis, such as developing risk assessment processes or endoscopic surveillance of Barrett's esophagus.Incremental net monetary benefits for other strategies are relatively small in comparison to predicted gains from early detection strategies.

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“…Respiratory complication is one of the common events after esophagectomy, with a reported incidence rate of up to 60% [1] . Respiratory failure due to pulmonary complications remains the major cause of postoperative morbidity and mortality after esophagectomy [1] .…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Study to Evaluate the Efficacy of a Preoperative Respiratory Rehabilitation Program to Prevent Postoperative Pulmonary Complications after Esophagectomy

et al. 2015

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Background/Aims: Patients with postoperative pulmonary complications after esophagectomy often have increased mortality. The purpose of the study was to examine the efficacy of preventing postoperative pulmonary complications by an intensive preoperative respiratory rehabilitation (PR) program for esophageal cancer patients. Methods: This study was a prospective randomized controlled study. Thirty patients in the PR group and 30 patients in the no preoperative respiratory rehabilitation (NPR) group were included. The PR group received preoperative rehabilitation for more than 7 days, while the NPR group did not receive any preoperative rehabilitation. All patients underwent postoperative rehabilitation from the first postoperative day. The postoperative pulmonary complications were evaluated using the Clavien-Dindo classification (CDC) and the Utrecht Pneumonia Scoring System (UPSS). Results: The CDC grade in the PR group was significantly lower than that in the NPR group (p = 0.014). The UPSS score in the PR group was significantly lower than that in the NPR group at postoperative day 1 (p = 0.031). In the multivariate analysis, NPR was an independent risk factor for postoperative pulmonary complications greater than CDC grade II (OR: 3.99, 95% CI: 1.28-12.4, p = 0.017). Conclusions: This study showed that the intensive PR program was capable of reducing the postoperative pulmonary complications in esophageal cancer patients.

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Factors Associated with Postoperative Pulmonary Morbidity After Esophagectomy for Cancer

Cited by 155 publications

References 30 publications

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

Modeling the Cost-effectiveness of Strategies for Treating Esophageal Adenocarcinoma and High-grade Dysplasia

Randomized Controlled Study to Evaluate the Efficacy of a Preoperative Respiratory Rehabilitation Program to Prevent Postoperative Pulmonary Complications after Esophagectomy

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