Residents of Ilorin South Local Government Area (LGA), Kwara State, Nigeria, were studied to see how Covid-19 lockdown affected their health. The survey was descriptive in nature. For this investigation, a total of 300 inhabitants were chosen using a multi-stage sampling process. Data was collected using a researcher-designed questionnaire with a reliability coefficient of 0.69. To describe the demographic characteristics of the participants, data was analyzed using percentages. The research question was answered using mean and rank order. Hypothesis one was examined with an independent t-test, while hypotheses two, three, and four were assessed with a 0.05 alpha level Analysis of Variance (ANOVA). The findings revealed that residents suffered an upsurge in substance use, sadness, anxiety, and loneliness as a result of the Covid-19 lockdown. They however did not suffer from obesity or change in eating habits. There were statistical significant differences in health consequences of covid-19 lockdown on residents based on gender (t (298) = 3.78, p˃0.05), age (F (4, 295) =13.725, p˂0.05), based on educational status (F (5, 294) =7.956, p˂0.05) and occupational status (F(3, 296) =22.041, p˂0.05). Given that the pandemic is still present, and people are becoming infected on a daily basis, there is a chance of another lockdown, and it was suggested, among others, that people should try to stay active by engaging and occupying themselves with learning new useful skills that will allow them to remain productive during the lockdown. This could help to mitigate the negative health effects of loneliness and anxiety during the lockdown. Keywords: Anxiety, Covid-19, Health Implications, Lockdown, Obesity, Residents.