Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1

Blanch, Jordi; Rousaud, Araceli; Martínez, Estebán; Lazzari, Elisa de; Milinkovic, Ana; Peri, Josep-Maria; Blanco, José-Luís; Jaen, Jesús; Navarro, V.; Massana, Guillem; Gatell, Josep-Maria

doi:10.1086/383573

Cited by 80 publications

(56 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even though the sample size was small, men scored lower on negative mood and homosexual men scored lower on psychological functioning. On a subsample of this study 8 applying a different questionnaire, Blanch and coauthors 9 found that changes in the breast, face, or legs were significantly associated with greater impairment of psychosocial functioning. In the multivariate analysis only changes in the breast remained significant.…”

Section: Lipodystrophy and Quality Of Life 581mentioning

confidence: 83%

“…6,7 Few studies have addressed quality-of-life issues in HIVinfected patients with LD, and its impact has not been es-tablished definitively. Some studies demonstrating effects have used instruments not widely validated in people with HIV infection, 8,9 while others have failed to find correlations with health-related quality of life. 10,11 The main objective of this study was to identify the impact of LD on the health-related quality of life in HIV-infected people taking HAART.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

Guaraldi

Murri

Orlando

et al. 2008

AIDS Patient Care and STDs

View full text Add to dashboard Cite

The impact of lipodystrophy (LD) on quality of life is high, but it has not been demonstrated in literature. The objective of the study was to assess the impact of LD on the health-related quality of life (HRQOL) in HIV-infected people on highly active antiretroviral therapy (HAART). Patients with LD phenotype defined by the Multicenter AIDS Cohort Study (MACS) were included. Three different methods were used to define LD severity: both patient and physician evaluation using the HIV Outpatient Study (HOPS) severity scales and the Lipodystrophy Case Definition (LDCD). The HRQOL was evaluated by MOS-HIV Health Survey. Four hundred one patients on HAART for a mean of 108 Ϯ 52 months were evaluated for LD at the Metabolic Clinic of Modena and Reggio Emilia University were enrolled from January 2003 to July 2006. According to self-perceived or physician-based HOPS, 106 (26.5%) and 122 (30.4%) patients had severe LD. Females had significantly more severe LD. Few HRQOL scores correlated to LD severity using the physician-based score (both HOPSph and LDCD), while all the HRQOL scores correlated with LD severity when a patient-based score was used (HOPSpt). In multiple linear regression analysis, Mental Health HRQOL score, gender, body mass index, age, body image satisfaction were independent predictors of patient-based (HOPSpt) LD, while none of the HRQOL scores, but female gender, age, waist-to-hip ratio, limb fat, and body image satisfaction were correlated with physician-estimated HOPSph LD severity. HRQOL was strongly correlated with LD severity when a patientbased score was used. For an overall assessment of the impact of LD on HIV-infected people, both patientbased and physician-based measures are required. 577

show abstract

Section: Lipodystrophy and Quality Of Life 581mentioning

confidence: 83%

mentioning

confidence: 99%

Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

Guaraldi

Murri

Orlando

et al. 2008

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…However, as QoL for HIV+ patients during HAART may change due to the positive effects of HAART counterbalanced by the effects of BFR [4], we included an extra domain containing five facets specific for HIV+ patients receiving HAART. These items were generated from preliminary subjects' interviews, opinions of clinicians and social scientists working in the field of HIV/AIDS and a literature search [6,9,23]. These facets included feeling ashamed in public, problems of dressing style and clothes' size, feeling less confident about one's health, fear of HIV status being revealed by changes in body-fat distribution and being embarrassed due to body-fat changes.…”

Section: Quality-of-life Assessmentsmentioning

confidence: 99%

“…The effects of BFR abnormalities on patients' QoL [8,9], the aetiology and prevalence of BFR [2,3,10] and strategies to manage metabolic disorders associated with BFR [11 12] have all been previously studied. However, there remains a paucity of information on the effects of interventions such as exercise training (EXS) on QoL in HAART-treated HIV+ patients with BFR in sub-Saharan Africa where the prevalence of HIV is highest in the world and access to HIV treatment is improving.…”

Section: Introductionmentioning

confidence: 99%

The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution

et al. 2008

View full text Add to dashboard Cite

Objective-Our objective was to examine the effects of exercise training (EXS) on quality of life (QoL) in highly active antiretroviral therapy (HAART)-treated HIV-positive (HIV+) subjects with body fat redistribution (BFR) in Rwanda.Methods-The effects of a randomised controlled trial of EXS on QoL were measured using World Health Organisation Quality of Life (WHOQOL)-BREF in HIV+ subjects with BFR randomised to EXS (n = 50; BFR + EXS) or no exercise training (n = 50; BFR + noEXS). Conclusions-Exercise training improved several components of QoL in HAART-treated HIV+ African subjects with BFR. Exercise training is an inexpensive and efficacious strategy for Results-At

show abstract

“…An understanding of the association between individual ARV drugs and body fat changes is important, because these fat changes can be stigmatizing, particularly when involving fat loss in the face 12,13 and have been associated with decreased quality of life 14 and decreased ARV adherence. 15 Treatment options including antiretroviral switch strategies as well as surgical implants and injectables to correct fat loss are being explored.…”

Section: Introductionmentioning

confidence: 99%

Antiretroviral Therapies Associated with Lipoatrophy in HIV-Infected Women

Tien

Barrón

Justman

et al. 2007

AIDS Patient Care and STDs

View full text Add to dashboard Cite

We previously demonstrated that HIV infection is associated with peripheral and central lipoatrophy in women. We now describe the association of specific antiretroviral drugs (ARV) with body fat changes over a four-year period from 1999 to 2003. 775 HIV-positive and 205 HIVnegative women in the Women's Interagency HIV Study with anthropometric measurements, weight, bioelectric impedance analysis and ARV collected semiannually were included in analysis. Exposure to ARV was defined as report of use for 3 consecutive semiannual study visits. The average 6-month change in weight, percent total body fat, and circumference measurements (i.e., hip, waist, chest, arm, and thigh) was compared between those exposed and those unexposed to the specific ARV for any of the same three consecutive visits. Weight, percent total body fat, and hip, waist, thigh, chest, and arm circumferences decreased in HIV-positive women, but increased in HIV-negative women on average for every six-month interval over the 4-year study period. Among the HIV-positive women, didanosine was the only ARV associated with decreases in circumference measures in the hip (−0.65 cm, 95% confidence interval [CI]: −1.18, −0.12), waist (−0.71 cm, 95% CI: −1.37, −0.04), chest (−0.71 cm, 95% CI: −1.17, −0.26), and arm (−0.23 cm, 95% CI: −0.48, 0.03; p = 0.08). These prospective data suggest that fat loss continues to predominate in HIV-positive women and exposure to didanosine for at least 12 months may further worsen fat loss.

show abstract

Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1

Cited by 80 publications

References 8 publications

Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution

Antiretroviral Therapies Associated with Lipoatrophy in HIV-Infected Women

Contact Info

Product

Resources

About