Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19

Disorders of gut-brain interaction post-COVID-19: a literature review

“…Further, the "COVID-19" AND "FD" search retrieved 14 results and only seven articles fulfilled the inclusion criteria (five of those had been identified in the previous searches). In addition, based on the focus of each paper, we classified them into the following subjects: impact of COVID-19 pandemic on the burden of DGBI [14][15][16][17][18][19][20][21][22][23][24] ; DGBI as risk factor for GI manifestations in patients with COVID-19 25 ; gastrointestinal sequels post-COVID-19 26,27 ; and prevalence and risk factors for post-COVID-19 DGBI [28][29][30] . In addition, one relevant paper, including data from Latin America regarding the impact of the pandemic on DGBI, not retrieved in the search was added.…”

“…Consequently, this study suggests that GI symptoms among patients with COVID-19 are associated with patient-and disease-related factors such as constitutional symptoms, younger age, previous presence of IBS, pre-existing pulmonary disease, and immunosuppressive therapy or chemotherapy 25 .…”

Impact of COVID-19 in individuals with and without pre-existent digestive disorders with a particular focus on elderly patients

“…Although their exact prevalence is still the subject of debate, GI symptoms are more and more frequently reported[ 8 ]. However, it is impossible to exclude a bias thriving from the increased awareness of GI manifestations[ 9 ]. Some authors reported a prevalence of GI involvement of around 31.9%[ 10 , 11 ], while others up to 61%[ 12 ].…”

“…Some studies have identified a lower prevalence of GI symptoms in the elderly population. This finding could be related to differences in gene expression of the ACE2, which seems to be directly correlated with age[ 9 , 28 , 29 ]. Older patients showed higher intestinal ACE2 mRNA expression, which could modify susceptibility to GI symptoms by influencing intestinal immunity and microbiota composition[ 29 , 30 ].…”

Trastornos de la interacción intestino-cerebro relacionados con COVID-19 y <i>Helicobacter pylori</i> en SII

“…En cuanto a los TIIC como factores de riesgo para el desarrollo de síntomas GI en la fase aguda de la COVID-19, solo se identificó un estudio por Aroniadis et al, realizado en Canadá, que informó que los pacientes mayores de 80 años reportaron menor frecuencia de síntomas GI y diarrea durante la COVID-19. Además, el SII fue casi 10 veces más común en aquellos que presentaron cualquier síntoma GI vs. los pacientes con COVID-19, y la diarrea fue el síntomas GI más común, con una razón de momios de 6.72 en estos pacientes con diagnóstico previo de SII 8 . Es de notar que durante el reciente Congreso de la Asociación Americana de Gastroenterología, el Digestive Disease Week (DDW), dos estudios analizaron este factor.…”