Factors associated with the presentation of erosive esophagitis symptoms in health checkup subjects: A prospective, multicenter cohort study

Mochizuki, Naoki; Fujita, Tsuyoshi; Kobayashi, Masao; Yamazaki, Yukinao; Terao, Shuichi; Sanuki, Tsuyoshi; Okada, Akihiko; Adachi, Masayasu; Murakami, Manabu; Arisaka, Yoshifumi; Uno, Koji; Masuda, Atsuhiro; Yoshida, Masaru; Umegaki, Eiji; Kutsumi, Hiromu; Azuma, Takeshi

doi:10.1371/journal.pone.0196848

Cited by 14 publications

(16 citation statements)

References 32 publications

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“…The questionnaire surveys of the control group participants were conducted in the medical examination center. The questionnaire surveys included a structured questionnaire [ 3 – 6 , 8 , 9 ] (Additional File 1 ), the GERD questionnaire (GerdQ) [ 10 ], the Patient Health Questionnaire (PHQ)-9 depression scale [ 11 ] and the General Anxiety Disorder (GAD)-7 anxiety scale [ 11 ]. The study was approved by the Ethics Committee of Xuanwu Hospital of Capital Medical University (reference number: 2015–11) and was performed in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…The structured questionnaire [ 3 – 6 , 8 , 9 ] (Additional File 1 ) included demographic information, lifestyle and eating habits, comorbidities and current medications. The demographic information included name, gender, age, education level, height, weight, marital status, monthly income, job and domicile [ 3 – 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Comorbidities included hypertension, ischemic heart disease, diabetes mellitus, hyperlipidemia and asthma [ 8 ]. Current medications included low-dose aspirin, clopidogrel, calcium channel blockers, angiotensin receptor blockers, statins, hypoglycemic agents, theophylline and β-receptor blockers [ 5 , 9 ].…”

Section: Methodsmentioning

confidence: 99%

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Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis

Wang

2021

BMC Gastroenterol

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Background The etiology of reflux esophagitis (RE) is multi-factorial. This study analyzed the relationship of depression, anxiety, lifestyle and eating habits with RE and its severity and further explored the impact of anxiety and depression on patients’ symptoms and quality of life. Methods From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in this survey. They were divided into the RE group (patients diagnosed with RE on gastroscopy, n = 361) and the control group (healthy individuals without heartburn, regurgitation and other gastrointestinal symptoms, n = 328). The survey included general demographic information, lifestyle habits, eating habits, comorbidities, current medications, the gastroesophageal reflux disease (GERD) questionnaire (GerdQ), the Patient Health Questionnaire-9 depression scale and the General Anxiety Disorder-7 anxiety scale. Results The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis identified the following factors as related to the onset of RE (p < 0.05): low education level; drinking strong tea; preferences for sweets, noodles and acidic foods; sleeping on a low pillow; overeating; a short interval between dinner and sleep; anxiety; depression; constipation; history of hypertension; and use of oral calcium channel blockers. Ordinal logistic regression analysis revealed a positive correlation between sleeping on a low pillow and RE severity (p = 0.025). Depression had a positive correlation with the severity of symptoms (rs = 0.375, p < 0.001) and patients’ quality of life (rs = 0.306, p < 0.001), whereas anxiety showed no such association. Conclusions Many lifestyle factors and eating habits were correlated with the onset of RE. Notably, sleeping on a low pillow was positively correlated with RE severity, and depression was positively related to the severity of symptoms and patients’ quality of life.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis

Wang

2021

BMC Gastroenterol

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“…EGD is the most important diagnostic tool for confirming the diagnosis of GERD. The identification of Barrett's esophagus, mucosal breaks such as esophagitis, hiatal hernia, and biopsies to rule out of malignancy are allowed by EGD [59606162636465].…”

Section: Resultsmentioning

confidence: 99%

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

et al. 2018

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The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamental information such as the definition, symptoms, and diagnostic tools of GERD and a recommendation statement about its surgical treatment. The recommendations presented 5 debates regarding fundoplication: 1) comparison of the effectiveness of medical and surgical treatments, 2) effectiveness of surgical treatment in cases of refractory GERD, 3) effectiveness of surgical treatment of extraesophageal symptoms, 4) comparison of effectiveness between total and partial fundoplication, and 5) effectiveness of fundoplication in cases of hiatal hernia. The present guideline is the first to demonstrate the efficacy of the surgical treatment GERD in Korea.

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“…In a prospective questionnaire, the frequency of UGSs in the past 3 months was investigated (i.e., never, <1 day/month, 1 day/month, 2-3 days/month, 1 day/week, >1 day/ week, or every day) according to our previous report. 28 Reflux symptoms were measured according to the frequency of heartburn and/or acid regurgitation. PDS symptoms were measured according to the frequency of bothersome postprandial fullness and/or early satiation.…”

Section: Methodsmentioning

confidence: 99%

Influence of sex on the association between body mass index and frequency of upper gastrointestinal symptoms

et al. 2020

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Background and Aim: Upper gastrointestinal symptoms (UGSs), including reflux and dyspeptic symptoms (postprandial distress syndrome [PDS] and epigastric pain syndrome [EPS]), affect health-related quality of life. However, the influence of sex on the relationship between body mass index (BMI) and UGSs remains controversial. This study investigates the influence of sex on this association in healthy subjects. Methods and Results: We utilized the database of a prospective, multicenter, cohort study of 7112 subjects who underwent upper endoscopy for health screening. A multivariable logistic regression analysis was conducted to assess the association between BMI and UGSs stratified by sex, adjusting for clinical features. The influence of sex on the association between the overlapping of UGSs and BMI in symptomatic subjects was also investigated. Reflux symptoms were significantly associated with high BMI (multivariable odds ratio [OR] 1.36; 95% confidence interval [CI] 1.10-1.67, P = 0.004). PDS symptoms were significantly associated with low BMI (OR 2.37; 95% CI 1.70-3.25; P < 0.0001), but EPS symptoms were not associated with BMI. The association between reflux symptoms and higher BMI was limited to men (men: OR 1.40; 95% CI 1.10-1.77; P = 0.005, women: P = 0.40). sex did not influence the association between the presence of PDS symptoms and lower BMI. The percentage of overlapping of all three symptoms (reflux, PDS, and EPS) was higher in women than in men (19.9% [58/292] vs 10.5% [49/468], P = 0.0002). Conclusions: The influence of BMI on the presence of UGSs was significantly different according to sex in this large-scale cohort.

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Factors associated with the presentation of erosive esophagitis symptoms in health checkup subjects: A prospective, multicenter cohort study

Cited by 14 publications

References 32 publications

Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis

Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

Influence of sex on the association between body mass index and frequency of upper gastrointestinal symptoms

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