Factors contributing to improved local control after mastectomy in patients with breast cancer aged 40 years or younger

Abstract

Long-term local control rates were studied in a series of 659 patients with invasive breast cancer aged 40 years or younger, who underwent mastectomy in general hospitals in the southern part of the Netherlands between 1988 and 2005. During a median follow-up time of 6.0 years, 34 patients developed a local recurrence in the chest wall without previous or simultaneous evidence of distant disease. The 5- and 10-year actuarial local recurrence rates for the total group were 5.6% (95% confidence interval [95% CI], 3.5-7.7%) and 7.3% (95% CI, 4.7-9.9%), respectively. A multivariate analysis showed that patients receiving radiotherapy (hazards ratio [HR], 0.29; 95% CI, 0.10-0.96) or adjuvant systemic treatment (HR 0.23; 95% CI, 0.08-0.65) had a significantly lower risk of local recurrence. It is concluded that excellent local control rates can be obtained with mastectomy in young women with breast cancer, especially in those who receive adjuvant systemic treatment and/or radiotherapy.

Breast cancer cases of female patients under 35�years of age in Togo: A series of 158�cases

“…The other series, unlike ours, report very little T3T4 (17,18). Lammers et al (18) reported 9% T3 and 2% T4. The advanced stages observed in the current series were determined to be associated with delays in diagnosis; frequently, patients consulted health structures in very advanced clinical phases explaining the predominance of the highly evolved stages.…”

“…Nodal invasion with capsular rupture in our series was found in 22.8% of cases and in 40% in the series of Bollet et al (16). The other series, unlike ours, report very little T3T4 (17,18). Lammers et al (18) reported 9% T3 and 2% T4.…”

Are breast conservation and mastectomy equally effective in the treatment of young women with early breast cancer? Long-term results of a population-based cohort of 1,451 patients aged ≤40 years

“…The 10-year local relapse rate for women aged ≤40 years varies between 19% and 35% after BCT and between 7% and 12% after mastectomy [8,9,11,12,6]. In two previous reports concerning women ≤40 years we found 5-and 10-year actuarial local relapse rates of 9% and 17.9%, respectively, after BCT [13] and of 5.6% and 7.3% after mastectomy [14].…”

Prise en charge du cancer du sein infiltrant de la femme âgée de 40 ans ou moins

“…Lammers et al [104], sur une étude rétrospective de patientes de moins de 40 ans et traitées par mastectomie totale retrouvent globalement des taux de récidive locale à cinq et dix ans respectivement de 5,6 et 7,3 %. Ce taux diminue à 1,6 % à cinq ans en cas d'irradiation et dans les mêmes proportions en cas de chimiothérapie.…”