Factors Influencing Lung Function in Patients with Cystic Fibrosis in Western Romania

Abstract

Purpose The aim of this cross-sectional study was to identify the major factors influencing pulmonary function in CF patients from western side of Romania. Patients and Methods The study enrolled 51 patients with CF between the ages of 6 and 27.8 years who were monitored at regular visits to the National Cystic Fibrosis Centre and Pius Branzeu County Hospital in Timisoara, Romania, over a period of 2 years. The relationships between lung function, as measured by forced expiratory volume in 1 s (FEV 1 ), with patient age, sex, body mass index (BMI), pancreatic insufficiency (PI), microbial infection, CF-related diabetes (CFRD), CF-associated liver disease (CFLD), and physical activity <30 min/day, were evaluated by multivariate regression analysis. Results The results showed that FEV1 was 0.32% higher for each increase in percentile of BMI (95% confidence interval: 0.034–0.619). In addition, mean FEV 1 was 1.52% lower with every year rise of age. PI and female sex increased the risk of impaired lung function (FEV 1 <60%). The factors most closely correlated with pulmonary function in pediatric CF patients were current age (negative) and BMI (positive). Conclusion The findings of this study, in combination with what is known from other studies in CF, suggest that a better nutritional status and infection prophylaxis should be part of a comprehensive clinical management strategy for pediatric CF in Romania.

The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study

“…In our study, a lower BMI was associated with a higher LCI (p = 0.001); poor nutritional status was associated with worse lung function and a decreased vitamin D level, as stated in previously published journals [2,44].…”

“…This study reports that, in the presence of CFLD, lung function is more deteriorated, as expressed by a higher LCI value (p = 0.000). A previous study [2] has proved that the presence of co-morbidities such as CFLD and CFRD is unrelated to lung function, as expressed by spirometry. Although a recent study about abnormal glucose tolerance and lung function in cystic fibrosis patients had concluded that patients with abnormal glucose tolerance or even with CFRD [37] have worse lung function [38], these findings were not supported by our study.…”

“…Cystic fibrosis is a polymorphic disease with an outcome strongly driven by the associated lung disease. Even with newly discovered potentiators [1], the lung and its function must be maintained in the best condition for the greatest life expectancy and quality of life [2].…”

Antibiotherapy in Children with Cystic Fibrosis—An Extensive Review

“…Cystic fibrosis (CF) is the most common potentially fatal monogenic disease in the Caucasian population, with autosomal recessive transmission and a remarkable clinical polymorphism [ 1 ]. Typical CF manifestations include obstructive lung disease and chronic diarrhea, with several complications such as liver and bone disease, CF-related diabetes, which can occur in time [ 2 ].…”

Editorial: Advances in lung ultrasound: from child to adulthood diseases

“…The study‘s outcome revealed that FOT is a consistent alternative technique for lung function measuring in the study population, being able to assess expiratory flow limitation as well as lung compliance changes. The importance of the study resides in functional evaluation of bone- and lung-affecting chronic disease, especially significant as lung disease is the most important outcome predictor for this pathology ( 5 ), and it is imperative to envisage the changes in lung structure and function ( 6 ).…”