Factors influencing serum total tryptase concentrations in a general adult population

Gonzalez-Quintela, Arturo; Vizcaíno, Luis; Gudé, Francisco; Rey, José Manuel Gándara; Meijide, L. M.; Fernández-Merino, Carmen; Linneberg, Allan; Vidal, Carmen

doi:10.1515/cclm.2010.124

Cited by 77 publications

(64 citation statements)

References 21 publications

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“…In our study, ST levels were higher in men than in women, in agreement with the study by Komarow et al [34] in atopic children and the Spanish study [15]. Alcohol consumption was negatively associated whereas smoking was positively associated with ST levels.…”

Section: Discussionsupporting

confidence: 93%

“…This confirms the results of the Spanish population study [15] that found a tendency towards higher ST levels in obese persons and persons with the metabolic syndrome. The Spanish study included one third of the number of participants compared to the present study.…”

Section: Discussionsupporting

confidence: 91%

“…Other studies have also noticed a steady increase in ST level with age [6,15,32]. Our data from a general population indicate that age is such an important factor that different ST reference levels for younger and older persons may be warranted.…”

Section: Discussionsupporting

confidence: 63%

“…However, the studies on this subject have included a limited number of patients [12,13,14]. A Spanish general population study [15] in 420 adults found that increasing ST levels were associated with increasing BMI and the metabolic syndrome, but these associations were not statistically significant after adjustment for potential confounders. In the present study in an adult general population in Denmark, we aimed to investigate a possible association between ST and BMI.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Fenger

Linneberg

Vidal

et al. 2011

Int Arch Allergy Immunol

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Background: Recent studies indicate that mast cells are more abundant in the obese state. Total serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been consistently linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. The aim of this study was to investigate determinants of ST and whether a potential association between obesity and allergic respiratory disease would be influenced by levels of ST in obese persons. Methods: Measurements of ST (ImmunoCAP Tryptase assay), atopy (skin prick test reactivity), methacholine bronchial hyperresponsiveness (BHR), body mass index (BMI) and serum lipids were performed in a general population of 1,216 persons aged 15–69 years. Results: ST increased significantly with increasing BMI. The median ST level increased from 3.3 µg/l in persons with BMI <25 to 4.4 µg/l in persons with BMI >30, p < 0.0001. Age (p < 0.0001), male sex (p = 0.0009) and smoking (p = 0.022) were positively associated with ST, whereas alcohol consumption (p = 0.005) was inversely associated with ST. ST was not associated with atopy, symptoms of allergic respiratory disease or BHR. A positive association between symptoms of allergic respiratory disease and obesity (OR = 1.98, 95% CI = 1.25–3.14) was not influenced by obesity-related differences in ST. Conclusions: Increasing BMI was significantly associated with increasing ST and the prevalence of symptoms of allergic respiratory disease. However, mast cell activity/burden (assessed by ST levels) did not influence the association between BMI and asthma/rhinitis symptoms.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Fenger

Linneberg

Vidal

et al. 2011

Int Arch Allergy Immunol

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“…In this retrospective study, a slight but significant decrease of sBT levels (2.5%/year) over time was determined. In previous studies, sBT levels were reported to increase with age [42,43]. Investigators attributed a decrease in sBT levels, which is in contrast to the physiological process, to the effect of VIT.…”

Section: Discussionmentioning

confidence: 99%

Increased Osteopontin Levels in Children Undergoing Venom Immunotherapy May Serve as a Marker of Clinical Efficacy

Yavuz¹,

Soyer²,

Şekerel³

et al. 2014

Int Arch Allergy Immunol

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Background: Venom immunotherapy (VIT) has its effect by modulating various mediators resulting in immune tolerance. The aim of this study was to measure changes in plasma osteopontin (OPN) and serum basal tryptase (sBT) levels over the course of 1 year of VIT in children with venom allergy. Methods: Children who suffered from a large local reaction (LLR) or a systemic reaction (SR) after insect stings were included along with control subjects. Measurements were performed before the initiation of VIT and 6 and 12 months after it had been started. Results: A total of 58 children (24 with SR, 18 with LLR and 16 control subjects) with a median age of 9.5 years (range 6.7-12.8) were enrolled. The plasma OPN levels of patients with LLR [median 1,477 ng/ml, interquartile range (IQR) 1,123-1,772] were significantly higher than patients with SR (882 ng/ml, 579-1,086; p < 0.001) and healthy control subjects (1,015 ng/ml, 815-1,203; p = 0.002). A significant increase in plasma OPN levels in children was determined after the 1-year VIT. The sBT levels of children with SR (4.1 ng/ml, 3.6-5.8) were significantly higher than children with LLR (3.1 ng/ml, 2.5-4.0) and control subjects (3.0 ng/ml, 2.9-3.8; p = 0.001). There was no significant change in the sBT levels of the patients after the 1-year VIT. Conclusions: The results of our study showed higher baseline levels of OPN in children with LLR compared to control subjects and children with SR. In children with SR, OPN levels were increased after the 1-year VIT. Our results may suggest a possible association between OPN and successful VIT in children.

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Estimating the within‐subject (CV_I) and between‐subject (CV_G) biological variation of serum tryptase

Skarbø

Vinnes

Wentzel‐Larsen

et al. 2021

Immunity Inflam & Disease

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Background: Tryptase is used as a biomarker to support the diagnosis of anaphylaxis and hematologic diseases. In the event of a mast cell activation during anaphylaxis, a temporary increase in the concentration of tryptase may be seen. On the basis of clinical studies, an increase of 2 µg/L + 20% from basis level has been proposed as significant. To evaluate the increase in tryptase levels, the within-subject (CV I ) and between-subject (CV G ) biological variations should be known. This study was conducted to estimate the biological variation of tryptase and to identify the reference change value (RCV).Methods: Blood samples were collected from healthy volunteers once a week consecutively over a 10-week period. Tryptase was measured by the use of a fluoroenzyme immunoassay (ImmunoCAP TM ; Thermo Fisher Scientific), and linear mixed-effects models were used to calculate the biological variation and RCV for both nontransformed and log-transformed tryptase.Results: Fourteen presumably healthy young adults (six males and eight females, age 23-35 years) were included. The CV I was 5.6% and the CV G was 31.5% (nontransformed data). Log-transformed data showed similar results.The analytical variation (CV A ) was 6.3% and the RCV was 23.5%. Conclusions: Young healthy adults without ongoing allergic reactions show low within-subject biological variation. Higher biological variation was observed between subjects.

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Factors influencing serum total tryptase concentrations in a general adult population

Abstract: Serum total tryptase concentrations in adults are not significantly modified by atopy status, but may be modified by lifestyle factors, such as alcohol consumption and gender. Serum total tryptase concentrations are particularly dependent on age.

Cited by 77 publications

References 21 publications

Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Increased Osteopontin Levels in Children Undergoing Venom Immunotherapy May Serve as a Marker of Clinical Efficacy

Estimating the within‐subject (CV_I) and between‐subject (CV_G) biological variation of serum tryptase

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Factors influencing serum total tryptase concentrations in a general adult population

Abstract: Serum total tryptase concentrations in adults are not significantly modified by atopy status, but may be modified by lifestyle factors, such as alcohol consumption and gender. Serum total tryptase concentrations are particularly dependent on age.

Cited by 77 publications

References 21 publications

Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Determinants of Serum Tryptase in a General Population: The Relationship of Serum Tryptase to Obesity and Asthma

Increased Osteopontin Levels in Children Undergoing Venom Immunotherapy May Serve as a Marker of Clinical Efficacy

Estimating the within‐subject (CVI) and between‐subject (CVG) biological variation of serum tryptase

Contact Info

Product

Resources

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Estimating the within‐subject (CV_I) and between‐subject (CV_G) biological variation of serum tryptase