Factors influencing the quality of sulfanilamide preparations (review)

Ermakova, G. A.; Skachilova, S. Ya.; Voronin, V. G.; Shramova, Z. I.

doi:10.1007/bf00764695

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…The modified Griess reaction has been perfectly adapted for onchip reaction with digital image analysis. This phenomenon may be attributed to the degradation of the Griess reagent 52,53 . On the other hand, a common drawback associated with the colorimetric detection of nitrit e refers to the Griess reagent stability 40 , which may be affect ed depending on the storage mode prior to use.…”

Section: Resultsmentioning

confidence: 99%

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Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

2015

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This study reports the use of microfluidic paper-based analytical devices (µPADs) associat e d with colorimetric detection for the determination of nitrite in clinical, food and environment a l samples. µPADs were fabricat ed by simple and fast stamping process in a geomet ry containin g eight circular detection zones and one central zone to sample inlet interconnected by microfluid i c channels . The colorimet ric determination of nitrite was performed through the modified Gries s reaction. Detection zones were spotted with a 0.75 µL aliquot of a solution containing 50 mmol L -1 sulfanilamide, 1.2 mol L -1 hydrochloric acid and 4 mmol L -1 N-(1-napthyl)ethy lenediamin e . The monitoring of the background colorimetric response revealed good stability over 12h for devices stored in the absence of light. After the addition of standard or real samples, the result in g images were captured with a scanner, converted to a color scale and analyzed in the magen t a channel. The analytical sensitivity and the limit of detection achieved after a preconcentrat io n stage were 0.56 (AU/µM ) and 5.6 µM , respectively. The preconcentrat ion provided an enrichment factor of ca. 3.2 times. The concentration levels of nitrite were successful ly determined in saliva, preservative water, ham, sausage and river water samples. The concentrat ion levels attained for each sample using µPADs were compared to the values found by spectrophotomet ry and there was no significative difference from one another at a confiden c e level of 95%.

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Section: Resultsmentioning

confidence: 99%

“…2 times higher than that observed for those stored for 12 h. This phenomenon may be attributed to the degradation of the Griess reagent. 52,53 This problem can be overcome by encapsulating the Griess reagent in separated zones, as demonstrated by Bhakta and co-workers. 40 According to our results (see data shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

2015

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“…Considering that aniline-like compounds are known to readily oxidize in air, it was hypothesized that the pink blushing was linked to an oxidation during the drying, storage, and/or usage steps. For the specific case of sulfanilamide, Seikel [30] and Ermakova et al [31] reported that its decomposition proceeds mostly to the formation of azobenzene-4,4′-disulphonamide and azoxybenzene-4,4′-disulphonamide. Therefore, the objective was to implement the simplest and least expensive strategy that can effectively limit the exposure of the reagents to the environment without interfering with the analysis.…”

Section: Resultsmentioning

confidence: 99%

Determination of nitrite in saliva using microfluidic paper-based analytical devices

Bhakta

Borba

Taba

et al. 2014

Analytica Chimica Acta

154

103

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Point-of-care platforms can provide fast responses, decrease the overall cost of the treatment, allow for in-home determinations with or without a trained specialist, and improve the success of the treatment. This is especially true for microfluidic paper-based analytical devices (μPAD), which can enable the development of highly efficient and versatile analytical tools with applications in a variety of biomedical fields. The objective of this work was the development of μPADs to identify and quantify levels of nitrite in saliva, which has been proposed as a potential marker of periodontitis. The devices were fabricated by wax printing and allowed the detection of nitrite by a colorimetric reaction based on a modified version of the Griess reaction. The presented modifications, along with the implementation of a paper-based platform, address many of the common drawbacks (color development, stability, etc.) associated with the Griess reaction and are supported by results related to the design, characterization, and application of the proposed devices. Under the optimized conditions, the proposed devices enable the determination of nitrite in the 10 to 1000 μmol L−1 range with a limit of detection of 10 μmol L−1 and a sensitivity of 47.5 AU [log (μmol L−1)]−1. In order to demonstrate the potential impact of this technology in the healthcare industry, the devices were applied to the analysis of a series of real samples, covering the relevant clinical range.

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“…For this reason, each component of the Griess reagent was added in separate uidic layers to ensure the analyte would react sequentially and to increase the stability and lifetime of the device. 66,67 Device time life can be extended to 30 days if vacuum sealed and refrigerated in the freezer at −20 °C. 68 In agricultural soils, the nitrate concentration can vary from 1 to 5 mmol L −1 .…”

Section: Colorimetric Detection Of Analytesmentioning

confidence: 99%

Low-cost precision agriculture for sustainable farming using paper-based analytical devices

Albuquerque,

Makara,

Ferreira

et al. 2024

RSC Adv.

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Factors influencing the quality of sulfanilamide preparations (review)

Cited by 3 publications

References 9 publications

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

Determination of nitrite in saliva using microfluidic paper-based analytical devices

Low-cost precision agriculture for sustainable farming using paper-based analytical devices

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