2023
DOI: 10.3390/biomedicines11123336
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Factors Influencing the Total Functional Capacity Score as a Critical Endpoint in Huntington’s Disease Research

Jannis Achenbach,
Benjamin Stodt,
Carsten Saft

Abstract: Background: The Total Functional Capacity (TFC) score is commonly used in Huntington’s disease (HD) research. The classification separates each disease stage (1–5), e.g., as an inclusion criterion or endpoint in clinical trials accepted by the Food and Drug Administration (FDA). In addition to the quantification of age- and CAG-repeat-dependent effects as well as interacting effects of both on the TFC, we aimed to investigate factors influencing the TFC, such as neuropsychiatric, educational, and cognitive dis… Show more

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