Factors predicting double embryo implantation following double embryo transfer in assisted reproductive technology: implications for elective single embryo transfer

Martin, Caitlin; Chang, Jeani; Boulet, Sheree L.; Jamieson, Denise J.; Kissin, Dmitry M.

doi:10.1007/s10815-016-0770-9

Cited by 8 publications

(13 citation statements)

References 33 publications

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“…Steinberg et al (2013) found in a large retrospective study that the strongest predictors for live birth following SET were: transferring blastocysts compared with cleavage embryos, maternal age younger than 38 years, having >3 embryos available for cryopreservation and retrieving >10 oocytes. In another recent retrospective study, predictors for double embryo implantation were blastocyst transfer, retrieving >10 oocytes and age <35 years (Martin et al, 2016). Another smaller study showed that embryo quality and age are the strongest predictors of good outcomes (Hunault et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Cumulative live birth rate following elective single blastocyst transfer compared with double blastocyst transfer in women aged 40 years and over

Tannus

Cohen

Son

et al. 2017

Reproductive BioMedicine Online

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This retrospective cohort study aimed to identify predictive factors for live birth following blastocyst transfer in women aged 40-43, and to compare the cumulative live birth rate (LBR) following elective single blastocyst (eSBT) and double blastocyst (DBT) transfer. The study included 411 women who had fresh blastocyst transfers on day 5. In stepwise logistic regression, independent predictive factors for live birth were: transferring fully expanded blastocysts (Gardner stage ≥3) (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.59-9.71) and transferring two blastocysts compared with a single blastocyst (OR 1.7, 95% CI 1.08-2.9). Maternal age was not found to be significant (OR 0.78, 95% CI 0.62-1.1). When comparing eSBT (n = 150) with DBT (n = 151), the DBT group achieved higher LBRs (26.5 versus 19.3%, P = 0.017) and higher multiple births (0 versus 17.5%, P = 0.02). However, the cumulative LBR was similar (28.0 versus 31.1%), with significantly lower multiple births in the eSBT group (0 versus 14.9%, P = 0.03). These results indicate that in women aged 40-43, when fully expanded blastocysts are achieved, maternal age is not a predictor for live birth, and eSBT can be performed without compromising cumulative LBRs.

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Section: Discussionmentioning

confidence: 99%

Cumulative live birth rate following elective single blastocyst transfer compared with double blastocyst transfer in women aged 40 years and over

Tannus

Cohen

Son

et al. 2017

Reproductive BioMedicine Online

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“…It is well known that maternal age is the most significant indicator for double embryo implantation following DET (Kim et al 2015;Martin et al 2016). Various studies have consistently shown that oocytes from women over 40 years of age have decreased quality (Alasmari et al 2016;Hourvitz et al 2009); subsequently, the resultant embryos will show declining developmental potentials (Marquez et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Martin et al specified the strongest negative predictor of double embryo implantation was age ≥35 years compared to age <35 years after double embryo transfer (DET) (Martin et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Manuscript to be reviewed with a favorable prognosis, in order to maximize the chance of pregnancy with a single treatment. However, according to a large study performed in the USA, women of over 35 years of age had up to 22.1 % of double embryo implantation in the favorable prognosis group in DET cycles (Martin et al 2016). A report from Finland estimated the twin pregnancy rate to be 17.7%, when two embryos were transferred in women aged 36-39 years (Veleva et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Peer Review #2 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

2020

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Twin pregnancies are associated with greater risk of neonatal morbidity and mortality than a singleton. This study was performed to investigate the twin pregnancy rate when two vitrified-warmed embryos are transferred in women of advanced reproductive age (≥ 35 years at the time of oocyte retrieval) and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). A retrospective analysis of data which included 2038 women aged 35 to 45 years, who underwent vitrified-warmed double embryo transfer (DET), from January 2013 and December 2016 was undertaken. Pregnancy and twin rates were estimated after stratifying by prognostic profile. The twin pregnancy rate was lower in women with poor prognosis (12/96, 12.5%) as compared with that in women with favorable prognosis (102/374, 27.3%) and average prognosis (78/346, 22.5%) with significant differences (P<. 05). The twin rate for women with favorable prognosis were 29.2% (70/240) in the cycles of women aged 35-37 years, 26.8% (26/97) in the cycles of women aged 38-40 years, and 16.2% (6/37) in the cycles of women >40 years. The twin rate for women with average prognosis were 25.8% (51/198) in the cycles of women aged 35-37 years, 22.0% (22/100) in the cycles of women aged 38-40 years, and 10.4% (5/48) in the cycles of women >40 years. The twin rate for women with poor prognosis were 15.3% (9/59) in the cycles of women aged 35-37 years, 10.3% (3/29) in the cycles of women aged 38-40 years, and 0% (0/8) in the cycles of women >40 years. From these results, it was concluded that women with a favorable or average prognosis have a high risk of twin pregnancies. The finding can be used to guide future practice: i.e. performing eSET in women with favorable or average prognosis and DET in women with poor prognosis.

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“…Age is a primary clinic criterion when considering a woman's candidacy for eSET. Martin et al (2016) specified the strongest negative predictor of double embryo implantation was age ≥35 years compared to age <35 years after double embryo transfer (DET). Kim et al (2015) reported maternal age ≤35 years was the cutoff value to predict twin pregnancy following DET.…”

Section: Introductionmentioning

confidence: 99%

The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

Xue

2020

PeerJ

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Twin pregnancies are associated with greater risk of neonatal morbidity and mortality than a singleton. This study was performed to investigate the twin pregnancy rate when two vitrified-warmed embryos are transferred in women of advanced reproductive age (≥35 years at the time of oocyte retrieval) and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). A retrospective analysis of data which included 2,038 women aged 35–45 years, who underwent vitrified-warmed double embryo transfer (DET), from January 2013 to December 2016 was undertaken. Pregnancy and twin rates were estimated after stratifying by prognostic profile. The twin pregnancy rate was lower in women with poor prognosis (12/96, 12.5%) as compared with that in women with favorable prognosis (102/374, 27.3%) and average prognosis (78/346, 22.5%) with significant differences (P < 0.05). The twin rate for women with favorable prognosis was 29.2% (70/240) in the cycles of women aged 35–37 years, 26.8% (26/97) in the cycles of women aged 38–40 years and 16.2% (6/37) in the cycles of women >40 years. The twin rate for women with average prognosis was 25.8% (51/198) in the cycles of women aged 35–37 years, 22.0% (22/100) in the cycles of women aged 38–40 years and 10.4% (5/48) in the cycles of women >40 years. The twin rate for women with poor prognosis was 15.3% (9/59) in the cycles of women aged 35–37 years, 10.3% (3/29) in the cycles of women aged 38–40 years and 0% (0/8) in the cycles of women >40 years. From these results, it was concluded that women with a favorable or average prognosis have a high risk of twin pregnancies. The finding can be used to guide future practice: that is, performing eSET in women with favorable or average prognosis and DET in women with poor prognosis.

show abstract

Factors predicting double embryo implantation following double embryo transfer in assisted reproductive technology: implications for elective single embryo transfer

Cited by 8 publications

References 33 publications

Cumulative live birth rate following elective single blastocyst transfer compared with double blastocyst transfer in women aged 40 years and over

Cumulative live birth rate following elective single blastocyst transfer compared with double blastocyst transfer in women aged 40 years and over

Peer Review #2 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

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