Factors Resulting Correlation and Differences in Renal Function Evaluation Index Using the Serum Cystatin C and Creatinine as Measured by an Enzymatic Method

Takahashi, M; Takayama, Sintarou; Suga, Hideyuki; Kadomura, Shota; Kojima, M.; Iwao, Kazunari; Takeda, Kiyotaka; Sato, Hideki; Kobayashi, Mariko; Shinmoto, Hiroshi

doi:10.1248/yakushi.18-00225

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Admittedly, it is not completely harmless. It can cause irreversible complete loss of renal function, and infection, bleeding, irreversible damage of renal function, and renal parenchyma may occur during treatment [ 20 ]. Moreover, the efficacy is relevant to many factors such as the shape and size of stones, with a high recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Super-Mini-PCNL and Ureteroscopy in Kidney Stone Sufferers and Risk Factors of Postoperative Infection

Yuan

Dai

et al. 2022

Journal of Healthcare Engineering

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To investigate the efficacy of super-mini-PCNL (SMP) and ureteroscopy in kidney stone (KS) sufferers and learn the risk factors of postoperative infection. A retrospective analysis was performed on 180 KS sufferers who were diagnosed and treated in our hospital from May 2019 to May 2021. They were enrolled into an observation group (OG, n = 104) and a control group (CG, n = 76) based on different treatment methods. Therein, the former was treated with SMP, while the latter was treated with ureteroscopy. The operation time, blood loss, hospital stay, recent stone-free rate (one week after operation), changes of serum creatinine (SCr), blood urea nitrogen (BUN), and cystatin C (CysC) levels before and after operation and complications were compared. Those sufferers were assigned to infected and uninfected groups based on their postoperative infection. The risk factors were assessed through logistic regression, and the model formula was established. The predictive value of this model for infection was tested through RO. Compared with CG, the operation time of the OG was longer, the blood loss and hospital stay were lower P < 0.05 , and the stone-free rate was higher P < 0.05 . Renal function indexes before and after treatment P > 0.05 and postoperative complications revealed no significant difference P > 0.05 . Logistic regression analysis manifested that preoperative urinary tract infection (OR: 4.690, 95% CI: 1.170–18.802), preoperative blood glucose level (OR: 11.188, 95% CI: 2.106–59.442), positive urine culture (OR: 10.931, 95% CI: 2.453–48.705), and infectious stones (OR: 3.951, 95% CI: 1.020–15.300) were independently related to infection. The risk prediction equation is logit p = − 8.913 + 1.545 × X 1 + 2.415 × X 2 + 2.392 × X 3 + 1.374 × X 4 , with a goodness-of-fit value of 0.545. The AUC is 0.930, so SMP is superior to ureteroscopy in KS sufferers. Preoperative urinary tract infection, preoperative blood glucose level, positive urine culture, and infectious stones are independently related to infection.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Super-Mini-PCNL and Ureteroscopy in Kidney Stone Sufferers and Risk Factors of Postoperative Infection

Yuan

Dai

et al. 2022

Journal of Healthcare Engineering

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“…The serum levels of Bun and cr are the classical markers of renal function (28). To evaluate the efficacy of Sal B on renal function after left ureteral ligation, the expression levels of Bun and cr in serum were determined in the present study.…”

Section: Effects Of Sal B On Bun/cr In the Serum Of Renal Fibrotic Micementioning

confidence: 98%

Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis

Wang

Pan

et al. 2020

Mol Med Rep

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Salvianolic acid B (Sal B) is one of the main water-soluble components of Salvia miltiorrhiza Bge. numerous reports have demonstrated that it could exert significant renal-protective effects, but the underlying mechanism remains unclear. The present study demonstrated that Sal B could alleviate renal injury by regulating the heparanase/syndecan-1 (HPSe/Sdc1) axis. In vivo, the serum creatinine, blood urea nitrogen, transforming growth factor-β1 (TGF-β1) and fibroblast growth factor-2 (FGF-2) levels, and the histopathological changes of mice kidneys were examined. Sal B could notably reduce the renal injury caused by left ureteral ligation. In vitro, Sal B downregulated the expression levels of HPSe/FGF-2/TGF-β1/α-smooth muscle actin and upregulated the expression levels of Sdc1/e-cadherin in angiotensin ii-stimulated HK-2 cells in a dose-dependent manner. in summary, to the best of the authors' knowledge, the present study provided evidence for the first time that Sal B could exert renal-protective effects via the inhibition of the HPSe/Sdc1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis.

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“…25 Slightly elevated of Cys-C level may indicate renal insufficiency, but its low level can also happen in early kidney damage. [26][27][28]…”

Section: Homocysteine Insulin and Folic Acidmentioning

confidence: 99%

Discrimination of Chronic Kidney Disease and Diabetic Nephropathy and Analysis of Their Related Influencing Factors

Liu

Guo

et al. 2020

DMSO

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Factors Resulting Correlation and Differences in Renal Function Evaluation Index Using the Serum Cystatin C and Creatinine as Measured by an Enzymatic Method

Cited by 4 publications

References 12 publications

Efficacy of Super-Mini-PCNL and Ureteroscopy in Kidney Stone Sufferers and Risk Factors of Postoperative Infection

Efficacy of Super-Mini-PCNL and Ureteroscopy in Kidney Stone Sufferers and Risk Factors of Postoperative Infection

Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis

Discrimination of Chronic Kidney Disease and Diabetic Nephropathy and Analysis of Their Related Influencing Factors

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