Factors that impact on immediate graft function in patients after renal transplantation

Sieńko, Jerzy; Wiśniewska, Magda; Ostrowski, Marek; Ciechanowski, Kazimierz; Safranow, Krzysztof; Chudyk, Adrian; Fronczyk, Aneta; Różański, Jacek; Kamiński, Marek; Sulikowski, Tadeusz; Romanowski, M; Pabisiak, Krzysztof; Paczkowski, M; Mizerski, A

doi:10.1016/s0041-1345(03)00766-8

Cited by 19 publications

(16 citation statements)

References 4 publications

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“…*P< .05. Cold ischemia and reperfusion injury at transplantation has been recognized for many years as a contributing factor in delayed graft function (22), acute rejection events (23,24), and chronic rejection (25,26). In transplantation of vital organs, the possibility of retrieving and transplanting an organ in close temporal and spatial proximity may be limited, and often, transportation is necessary.…”

Section: Figurementioning

confidence: 99%

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

Wranning

Dahm‐Kähler

Mölne

et al. 2008

Fertility and Sterility

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Section: Figurementioning

confidence: 99%

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

Wranning

Dahm‐Kähler

Mölne

et al. 2008

Fertility and Sterility

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“…In addition, the increased occurrence of delayed graft function in older donor kidneys [108] also suggests that the graft has more problems in overcoming I/R damage.…”

Section: Donor Agementioning

confidence: 99%

Chronic renal allograft rejection: Pathophysiologic considerations

Joosten¹,

Sijpkens²,

Kooten³

et al. 2005

Kidney International

189

122

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Chronic rejection is currently the most prevalent cause of renal transplant failure. Clinically, chronic rejection presents by chronic transplant dysfunction, characterized by a slow loss of function, often in combination with proteinuria and hypertension. The histopathology is not specific in most cases but transplant glomerulopathy and multilayering of the peritubular capillaries are highly characteristic. Several risk factors have been identified such as young recipient age, black race, presensitization, histoincompatability, and acute rejection episodes, especially vascular rejection episodes and rejections that occur late after transplantation. Chronic rejection develops in grafts that undergo intermittent or persistent damage from cellular and humoral responses resulting from indirect recognition of alloantigens. Progression factors such as advanced donor age, renal dysfunction, hypertension, proteinuria, hyperlipidemia, and smoking accelerate deterioration of renal function. At the tissue level, senescence conditioned by ischemia/reperfusion (I/R) may contribute to the development of chronic allograft nephropathy (CAN). The most effective option to prevent renal failure from chronic rejection is to avoid graft injury from both immune and nonimmune mechanism together with nonnephrotoxic maintenance immunosuppression.

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“…58 Thus, judicious selection of donorrecipient pairs and optimizing the need for graft with donor-recipient compatibility is an important step in reducing the negative effect associated with DGF.…”

Section: Torki Al Otaibi Et Al/experimental and Clinical Transplantatmentioning

confidence: 99%

“…Table 2 summarizes the studies reporting the risk factors associated with the incidence of DGF in living-donor kidney transplants. 11,17,31,32,33,38,41,44,46,48,52,54,58,64,65 Treating risks associated with DGF Given the paucity of data about the effects of and the risk factors for DGF in living-donor kidney transplant, studies that focus on treating these risk factors are also limited. However, given the effects of DGF after living-donor kidney transplant, strategies to minimize or prevent the risk of DGF are needed.…”

Section: Other Risk Factorsmentioning

confidence: 99%

Untitled

2016

Exp Clin Transplant

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With an increased incidence of living-donor kidney transplants, in response to increasing unmet needs for renal transplant, a clear understanding of determinants of posttransplant outcomes is essential. The importance of delayed graft function in deceased-donor kidney transplant is now part of conventional medical wisdom, due to the large amount of evidence focused on this aspect. However, the same is not true for living-donor kidney transplant, partly due to lack of evidence on this crucial clinical question and partly due to lack of awareness about this issue. The current review aims to highlight the importance of delayed graft function as a crucial determinant of outcomes in living-donor kidney transplant. An exhaustive search of online medical databases was performed with appropriate search criteria to collect evidence about delayed graft function after living-donor kidney transplant, with a special focus on studies from the Middle East. Data on incidence, impact, risk factors, and possible prevention modalities of delayed graft function in patients undergoing living-donor kidney transplant are presented. A key finding of this review is that contemporary incidence rates reported from the Middle East are comparatively higher than those reported from outside the region. Although in absolute terms the incidence is lower than deceaseddonor kidney transplant, the effects of delayed graft function on graft rejection and graft and patient survival are sufficiently large to warrant the formulation of specific treatment protocols. Key to formulating prevention and treatment strategies is identifying discrete risk factors for delayed graft function. Although this evidence is scant, an overview has been provided. Further studies examining different aspects of delayed graft function incidence after living-donor kidney transplant are urgently needed to address a so far little known clinical question.

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Factors that impact on immediate graft function in patients after renal transplantation

Cited by 19 publications

References 4 publications

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

Chronic renal allograft rejection: Pathophysiologic considerations

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