Failure of initial disease control in bullous pemphigoid: a retrospective study of hospitalized patients in a single tertiary center

Kremer, Noa; Zeeli, Tal; Sprecher, Eli; Geller, Shamir

doi:10.1111/ijd.13736

Cited by 11 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results were consistent with recently published studies carried out by Kremer et al, who found that arterial hypertension was the most frequent comorbidity in BP (in 64% of patients studied, p = 0.04). 21 In studies by Kwan et al and Cai et al, arterial hypertension was also the most frequent out of all comorbidities (in 62.8% and 59.3%, respectively). 13,20 In another study concerning BP patients, multi-morbidity was observed in 84% with the highest percentage for arterial hypertension.…”

Section: Association With Cardiovascular Diseasesmentioning

confidence: 92%

“…The fact is that this disease may play an important role in BP patients, especially since major drugs used to treat hypertension such as diuretics, ACE inhibitors or spironolactone can provoke BP. 6,13,[20][21][22] Among other comorbidities, single studies have demonstrated the association of BP with diabetes. [23][24][25] To confirm or reject the abovementioned discrepancies, the aim of this study was to assess the relationship between BP and selected comorbidities.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between neurological diseases, malignancies and cardiovascular comorbidities among patients with bullous pemphigoid: Case-control study in a specialized Polish center

Kalińska-Bienias¹,

Kowalczyk²,

Jagielski³

et al. 2019

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

Section: Association With Cardiovascular Diseasesmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The association between neurological diseases, malignancies and cardiovascular comorbidities among patients with bullous pemphigoid: Case-control study in a specialized Polish center

Kalińska-Bienias¹,

Kowalczyk²,

Jagielski³

et al. 2019

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…In particular, cardiovascular diseases result the most frequent comorbidities (70%), followed by CNS disorders (37%), type 2 diabetes (15%) and malignant tumors (14%) (5). In their study, Kremer et al have shown that arterial hypertension was the most frequent comorbidity in patients with BP (64% of patients, p=0.04) (6). Conversely, the use of some antihypertensive drugs (e.g.…”

Section: Discussionmentioning

confidence: 98%

A Monocentric Retrospective Observational Study of Comorbidities in Patients Affected by Autoimmune Bullous Diseases

Ferranti

Gobbo

Cicogna

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: Autoimmune bullous diseases (AIBDs) of the skin and mucosae include a heterogeneous group of chronic diseases, which could be associated with various comorbidities. The purpose of this study was to evaluate the comorbidity profiles of patients affected by AIBDs, who referred to the Dermatological Clinic of Padua from December 2015 to June 2018. Patients and Methods: A monocentric retrospective observational study was conducted on 157 patients with diagnosis of AIBDs. Patients' comorbidities were investigated during the periodic visits of follow-up and through the analysis of computerized medical records. Results: Among the 157 patients, 40 (25.5%) were diagnosed with PV, 15 (9.6%) with PF, and 102 (64.9%) with BP. Nine different comorbidities were observed, but only two of these were statistically significantly associated with BP: type 2 diabetes (p=0.0142) and neuropsychiatric disorders (p=0.015). Conclusion: BP is statistically significantly associated with type 2 diabetes mellitus and neuropsychiatric diseases. The correlation with neuropsychiatric pathologies is interesting for the possible bidirectional role in their etiology. The association with type 2 diabetes mellitus could suggest more caution in the administration of systemic corticosteroids, especially in elderly patients.

show abstract

“…For this disease, we found nine case series (36,48,63,(99)(100)(101)(102)(103)(104) of which two were prospective. In total 249 patients were enrolled.…”

Section: Bullous Pemphigoid (Bp)mentioning

confidence: 99%

On which evidence can we rely when prescribing off-label methotrexate in dermatological practice? – a systematic review with GRADE approach

Huizen

Vermeulen

Bik³

et al. 2021

Journal of Dermatological Treatment

View full text Add to dashboard Cite

If an authorized drug is prescribed for a use that is not described in the Summary of Product Characteristics, this is defined as 'off-label use.' Methotrexate is often used off-label for dermatological indications. Off-label use is permitted if physicians can justify the treatment based on scientific evidence available to them. Our objective here was therefore to summarize the evidence for the effectiveness, efficacy, and safety of the dermatological off-label use of methotrexate in a systematic review. We searched MEDLINE, EMBASE, and CENTRAL for studies for evidence on the effectiveness, efficacy, and safety of the off-label use of methotrexate in dermatological indications up to November 2019. We used the GRADE system to rate the quality of the evidence. The search retrieved 34,583 hits of which 3566 were selected after the title and abstract screening. After the full-text screening, 143 studies were included, which involved 3688 patients in total. We found low-quality evidence for the effectiveness, efficacy, and safety of the off-label use of methotrexate in 31 dermatological diseases.To optimize the quality of evidence to support off-label use, we need high-quality studies in which well-characterized patients are treated with standardized treatments regimens using well-validated outcomes relevant to patients and physicians.

show abstract

Failure of initial disease control in bullous pemphigoid: a retrospective study of hospitalized patients in a single tertiary center

Cited by 11 publications

References 28 publications

The association between neurological diseases, malignancies and cardiovascular comorbidities among patients with bullous pemphigoid: Case-control study in a specialized Polish center

The association between neurological diseases, malignancies and cardiovascular comorbidities among patients with bullous pemphigoid: Case-control study in a specialized Polish center

A Monocentric Retrospective Observational Study of Comorbidities in Patients Affected by Autoimmune Bullous Diseases

On which evidence can we rely when prescribing off-label methotrexate in dermatological practice? – a systematic review with GRADE approach

Contact Info

Product

Resources

About