Failure to complete treatment for latent tuberculosis infection in Portugal, 2013–2017: geographic-, sociodemographic-, and medical-associated factors

Sentís, Alexis; Vasconcelos, Paula Teles; Machado, Rita Sá; Caylà, Joan A.; Guxens, Mònica; Peixoto, Vasco Ricoca; Duarte, Raquel; Carvalho, Isabel; Carvalho, Carlos

doi:10.1007/s10096-019-03765-y

Cited by 10 publications

(15 citation statements)

References 25 publications

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“…Limited decision-making capacity, involvement in domestic work, unemployment, and facility located too far from the study region may all be contributing factors. 14 In our study to found that, There were a total of 140 individuals with pulmonary tuberculosis, both new suspicions and previously treated patients. The likelihood of developing TB was higher among the males (n=90, 64.2%) than the females (n=36, 50%).…”

Section: Discussionmentioning

confidence: 81%

Effective Use of Penicillin to Improve Culture Yield for Mycobacterium Tuberculosis

Anwar¹,

Fida²,

Mumtaz³

et al. 2023

PJMHS

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Background: The aim of this study to evaluate the Mycobacterium tuberculosis (MTC) sputum culture contamination and recovery between Lowenstein-Jensenmedium (LJ) contains Pencillin+LJ and free Pencillin LJ. Study design: This was a cross sectional study conducted at Khawaja Safdar Medical College, Sialkot /Allama Iqbal Memorial Hospital Sialkot for the duration of six months from September 2022 to February 2023. Methods: A total number of the participants was 140. The male and female gender were both included who suffered pulmonary tuberculosis (PTB). The sample n=140 were analyzed for culture and contamination. The sputum samples were taken in the early morning in the falcon tube and digested, decontaminated, and homogenized by Modified Petroff method. The specimen of sputum was processed on addition of Penicillin+ LJ media, and incubation was carried out at 37°C. After eight weeks, cultures were examined. The data were analyzed by SPSS 21 software. Results: The male 64.2% show greater number of cases as compared to female 36%. The suspected cases of PTB was compared with Pencillin+ LJ media and LJ media alone. 21.4% of the samples were positive mycobacterium (MTB), 79% were contaminated on LJ media while 93% were positive (MTB), and 7.1% of the samples were contaminated on LJ media without penicillin. This difference was statistically significant (p<0.005**). The grade 2+/3+ show 50% recovery by the treatment of pencillin+LJ on positive sample and 47% contaminated sample P<0.001** while graded scanty/+1 show recovery was 38%; p=0.001** with pencillin+LJ then 37% contaminated sample; p=0.002**. The difference in recovery between treatment with penicillin and without pencillin LJ was statistically significant; p<0.005. Conclusion: The contamination rate was reduced by 47% by penicillin+LJ media. Penicillin offered great alternatives for decreasing contamination in LJ alone. Penicillin should be further used as a medium supplement to enhance recovery for LJ media. Keywords: Culture media, Mycobacterium, Penicillin

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Section: Discussionmentioning

confidence: 81%

Effective Use of Penicillin to Improve Culture Yield for Mycobacterium Tuberculosis

Anwar¹,

Fida²,

Mumtaz³

et al. 2023

PJMHS

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“…Three of the included studies did not report where they were conducted 54 , 62 , 88 . The most frequent settings were: outpatient clinics and clinics (n = 41) 24 - 26 , 30 , 35 - 38 , 40 - 43 , 46 - 52 , 56 - 58 , 61 , 67 , 68 , 71 - 73 , 75 , 81 , 82 , 84 , 85 , 87 , 89 - 95 ; hospitals (n =19) 24 , 28 , 39 , 40 , 45 , 53 , 55 , 59 , 60 , 64 , 66 , 70 , 74 , 76 , 77 , 80 , 78 , 79 , 83 ; and penitentiaries (n = 4) 29 , 31 , 33 , 63 .…”

Section: Resultsmentioning

confidence: 99%

“…Most of the included studies (n = 49) did not specify patient profiles 24 - 33 , 35 - 37 , 40 - 44 , 47 , 49 , 51 , 52 , 54 , 55 , 57 - 59 , 60 , 63 - 65 , 67 , 68 , 70 , 71 , 77 , 79 , 81 - 87 , 89 , 90 , 93 , 94 , four studies involved patients with inflammatory bowel disease or immune-mediated inflammatory diseases 72 , 73 , 76 , 80 , four involved human immunodeficiency virus (HIV)-positive adults 56 , 61 , 74 , 91 , four involved patients who transplanted or had transplants 34 , 50 , 62 , 66 , and six involved health professionals 38 , 39 , 45 , 48 , 78 , 88 .…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the various treatment alternatives for LTBI globally, among the studies analyzed, 53 used INH for 9 months 24 - 28 , 30 - 34 , 38 - 46 , 49 - 54 , 58 , 61 , 63 , 64 , 67 , 69 , 72 - 74 , 76 , 77 - 79 , 80 , 81 , 82 - 87 , 89 , 91 , 92 , 94 , 95 , 40 used INH for 6 months 24 , 26 , 27 , 29 , 34 - 36 , 39 , 42 - 44 , 47 - 49 , 53 , 55 , 56 , 57 , 59 - 62 , 64 , 65 , 67 , 68 , 70 , 71 , 72 , 74 , 75 , 84 , 86 - 90 , 93 , 94 , 95 , and two used INH for 12 months 66 . Rifampicin monothera...…”

Section: Resultsmentioning

confidence: 99%

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Isoniazid use, effectiveness, and safety for treatment of latent tuberculosis infection: a systematic review

Sodré-Alves,

Toledo,

Zimmermann

et al. 2024

Rev. Soc. Bras. Med. Trop.

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Background: The treatment strategy for latent tuberculosis infection is to reduce the number of tuberculosis cases and consequently reduce the transmission of pathogenic bacteria. This study aimed to determine the safety, effectiveness, and adherence of isoniazid use for latent tuberculosis infection treatment. Methods: To identify studies on isoniazid use for latent tuberculosis infection, five electronic databases were searched. The methods and results are presented in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Most studies (53) used isoniazid for 9 months. The prevalence of use and adherence to treatment varied considerably (18% to 100%), and were evaluated by participant completion of isoniazid treatment for latent tuberculosis infection. The adverse events most frequently reported were hepatotoxicity, gastric intolerance, and neuropathy; the rates of occurrence ranged from < 1% to 48%. In the studies that evaluated the effectiveness of isoniazid for latent tuberculosis infection, the rate varied from 0 to 19.7% for patients who did not have active tuberculosis after the follow-up period. Conclusions: The importance of maintaining follow up for patients using isoniazid should be emphasized due to the risk of developing adverse events. Despite the treatment challenges, the rates of patients who used isoniazid and developed active tuberculosis during the follow-up period were low. We believe that isoniazid continues to contribute to tuberculosis control worldwide, and better care strategies are required.

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“…Loupy et al reported that in low calcium levels, impaired PTH secretion may be the cause of primary hypoparathyroidism. 27 Reduced vitamin D amounts might be induced by the effects of epilepsy itself and the epileptic seizures on the metabolism of vitamin D as seen in LEV-treated groups.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Levetiracetam as Anti-Epileptic Drug on Bone and Vitamin D Metabolism

Ustaoğlu¹

2020

Turkiye Klinikleri J Med Sci

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Epilepsy which affects ~1-2 % of the population worldwide is one of the most common neurodegenerative diseases. 1 In epilepsy, excessive discharge of cerebral neurons results in recurrent seizures. 2 All treatments for epilepsy aim to make the active lives of people easier by preventing further seizures while avoiding the side effects of the treatments. Primary treatment is to use anti-epileptic drugs (AEDs). How

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Failure to complete treatment for latent tuberculosis infection in Portugal, 2013–2017: geographic-, sociodemographic-, and medical-associated factors

Cited by 10 publications

References 25 publications

Effective Use of Penicillin to Improve Culture Yield for Mycobacterium Tuberculosis

Effective Use of Penicillin to Improve Culture Yield for Mycobacterium Tuberculosis

Isoniazid use, effectiveness, and safety for treatment of latent tuberculosis infection: a systematic review

The Effects of Levetiracetam as Anti-Epileptic Drug on Bone and Vitamin D Metabolism

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