Failure to establish spontaneous breathing at birth: A 5-year longitudinal study of newborns admitted for birth asphyxia in Enugu, Southeast Nigeria

Ekwochi, Uchenna; Asinobi, Nwabueze Isaac

doi:10.4103/jcn.jcn_34_18

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, severe asphyxia or less than 3 APGAR score at fth minute is an independent predictors and increases the hazards of death 3 times among new-borns with PNA. This is supported with the study conducted in Addis Ababa (36), Nigeria (37), Tanzania (7), and Cameroon (38). The reason for this nding might be perinatal asphyxia, which is a lack of blood ow or gas exchange to or from the fetus in the period immediately before, during, or after the birth process.…”

Section: Discussionsupporting

confidence: 81%

Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022

Tesfaye

Adugna

Getaneh

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Perinatal asphyxia is one of the preventable and treatable causes of neonatal mortality. However it is the fifth largest cause of under-five mortality. There are both long-term and short-term neurodevelopmental consequences of perinatal asphyxia, which can result in disability or even death. Even though management advancements, it remains one of the key public health issues in underdeveloped countries, including Ethiopia. Comorbidities are also understated therefore adequate information regarding the incidence of death and its predictors is required. Methods A four-year retrospective follow-up study was conducted from October 03 to November 02, 2022. From a total sample size, 616 data were collected by nurses reviewing charts using Kobo Toolbox software. Data was exported to STATA Version 14 for analysis. Cox proportional hazard assumption was checked and the model for the data was selected by Akaike Information Criteria. Finally, an adjusted hazard ratio with 95% CI was computed, and variables with a P-value < 0.05 in the multivariable analysis were taken as significant predictors of death. Result The overall incidence of mortality was 38.86/1000 days (95%CI: 33.85–44.60). The median time of follow-up was 15 days (95% CI: 14–20). The proportion of deaths was 202 (32.79%, 95% CI: 29.18–36.61) among neonates with perinatal asphyxia. While distance from health facility > 10 KM is (AHR: 2.25; 95%CI: 1.60–3.17), direct oxygen (AHR = 1.83; 95% CI: 1.35–2.48), APGAR score < 3 at fifth minute (AHR = 2.63; 95% CI: 1.03–6.73), prolonged ROM (AHR = 1.41; 95% CI: 1.02–1.94), and stage III HIE (AHR = 2.02; 95% CI: 1.18–3.47) were a predictors of mortality, among neonates with perinatal asphyxia. Conclusion The study found that, neonatal mortality among perinatal asphyxia remains high. Therefore, in order to reduce neonatal mortality among asphyxiated neonates, reducing prolonged ROM, APGAR score < 3 at fifth minute, using direct oxygen, stage III HIE, and a place of residences more than 10KM away from health facility.

show abstract

Section: Discussionsupporting

confidence: 81%

Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022

Tesfaye

Adugna

Getaneh

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Perinatal asphyxia is defined as the failure to establish spontaneous breathing at birth [1,2], leads to a transient interruption of oxygen availability that implies a risky metabolic challenge [3,4]. In developing countries neonatal mortality rate constitutes 42% of under-5 deaths [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Lafta¹,

Manther²,

Yousif³

2021

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Background: Liver cell injury commonly occurs after perinatal asphyxia. This study aimed to identify the neonatal and maternal factors related to hepatic dysfunction associated with birth asphyxia. Methods: A case control study was carried out in Basra comprising 43 asphyxiated newborns, and 57 healthy full terms enrolled as control. Serum levels of liver enzymes [alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP)] were measured and compared between the study and control groups. Levels beyond +2SD above the mean of control considered high. Statistical analysis was done using SPSS program version 20. Chi-Square test and ANOVA were used where appropriate, P-value <0.05 was considered as significant. Elevated levels of enzymes were studied in relation to selected neonatal and maternal variables. Results: Higher levels of liver enzymes were found related to gestational age > 40 weeks, newborn’s body weight > 4 Kg, mother’s age>35 years, parity > 4 children and maternal medical disease. The results were statistically significant (P<0.05). However, no statistical differences were detected regarding newborn’s gender and growth status, maternal education and mode of delivery. Conclusion: The study highlights the relationship between maternal and neonatal risk factors and perinatal asphyxia associated with hepatic dysfunction.

show abstract

Survival and predictors of asphyxia among neonates admitted in neonatal intensive care units of public hospitals of Addis Ababa, Ethiopia, 2021: a retrospective follow-up study

et al. 2022

View full text Add to dashboard Cite

Background Globally, perinatal asphyxia (PNA) is a significant cause of most neonatal deaths. Similarly, the burden of birth asphyxia in Ethiopia remains high (22.52%) and has been noted the second leading cause of neonatal mortality. Thus, researches on survival status and predictors of perinatal asphyxia are critical to tackle it. Therefore, the current study intended to determine the survival status and predictors of asphyxia among neonates admitted in Neonatal Intensive Care Units of public hospitals, Addis Ababa, Ethiopia. Methods Hospital-based retrospective follow-up study was conducted in four selected public hospitals of Addis Ababa from January 2016 to December 2020. Data were collected using a pretested structured questionnaire. Epi-data 4.6 and STATA Version 16 was used for data entry and analysis, respectively. Kaplan–Meier survival curve, log-rank test and Median time were computed. To find the predictors of time to recovery, a multivariable Cox proportional hazards regression model was fitted, and variables with a P-value less than 0.05 were considered statistically significant. Finally, the Schoenfeld residual test was used to check overall model fitness. Result Four hundred eleven admitted asphyxiated babies were followed a total of 3062 neonate-days with a minimum of 1 h to a maximum of 28 days. The Overall incidence density rate of survival was 10 (95% CI: 0.08–0.11) per 100 neonate-days of observation with a median recovery time of 8 days (95% CI: 7.527–8.473). Low birth weight (Adjusted hazard ratio [AHR]: 0.67, 95% CI: 0.47–0.96), stage II hypoxic ischemic encephalopathy (HIE) (AHR: 0.70, 95% CI: 0.51–0.97), stage III HIE (AHR: 0.44, 95% CI: 0.27–0.71), seizure (AHR: 0.61, 95% CI: 0.38—0.97), thrombocytopenia (AHR: 0.44, 95% CI: 0.24–0.80) and calcium gluconate (AHR: 0.75, 95% CI: 0.58–0.99) were found to be independent predictors of time to recovery of asphyxiated neonates. Conclusion In the current findings, the recovery time was prolonged compared to others finding. This implies early prevention, strict monitoring and taking appropriate measures timely is mandatory before babies transferred into highest stage of HIE and managing complications are recommended to hasten recovery time and increase survival of neonates.

show abstract

Failure to establish spontaneous breathing at birth: A 5-year longitudinal study of newborns admitted for birth asphyxia in Enugu, Southeast Nigeria

Cited by 4 publications

References 0 publications

Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022

Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022

Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Survival and predictors of asphyxia among neonates admitted in neonatal intensive care units of public hospitals of Addis Ababa, Ethiopia, 2021: a retrospective follow-up study

Contact Info

Product

Resources

About